From Wikipedia, the free encyclopedia
Amphetamine (pronunciation: i/æmˈfɛtəmiːn/; contractit frae alpha‑methylphenethylamine) is a potent central nervous seestem (CNS) stimulant o the phenethylamine class that is uised in the treatment o attention deficit hyperacteevity disorder (ADHD) an narcolepsy.
Clinical data | |
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AHFS/Drugs.com | entry |
Leecence data |
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Pregnancy category |
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Dependence liability | Pheesical: none Psychological: moderate |
Addiction liability | Moderate |
Routes o admeenistration | Medical: oral, nasal inhalation Recreational: oral, nasal inhalation, insufflation, rectal, intravenous |
ATC code |
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Pharmacokinetic data | |
Bioavailability | Rectal 95–100%; Oral 75–100%[1] |
Protein bindin | 15–40%[2] |
Metabolism | CYP2D6,[3] DBH,[4][5][6] FMO3,[7][8] XM-ligase,[9] an ACGNAT[10] |
Onset o action | Immediate |
Biological hauf-life | D-amph:9–11h;[3][11] L-amph:11–14h[3][11] |
Excretion | Renal; pH-dependent range: 1–75%[3] |
Identifiers | |
IUPAC name
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Synonyms | α-methylphenethylamine |
CAS Nummer | |
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DrugBank | |
ChemSpider | |
UNII | |
KEGG | |
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NIAID ChemDB | |
PDB ligand | |
ECHA InfoCard | 100.005.543 |
Chemical and physical data | |
Formula | C9H13N |
Molar mass | 135.2084 g/mol |
3D model (Jmol) | |
Density | 0.9±0.1 g/cm3 |
Meltin pynt | 11.3 °C (52.3 °F) [12] |
Bylin pynt | 203 °C (397 °F) [13] |
SMILES
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