FOXO3

FOXO3
Estruturas disponíveis
PDB	Pesquisa Human UniProt: PDBe RCSB
Lista de códigos id do PDB
	2K86, 2LQH, 2LQI, 2UZK
Identificadores
Nomes alternativos	FOXO3
IDs externos	OMIM: 602681 HomoloGene: 31039 GeneCards: FOXO3
Ontologia genética
Função molecular	• beta-catenin binding; • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific; • GO:0001948, GO:0016582 ligação a proteínas plasmáticas; • protein kinase binding; • chromatin DNA binding; • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity; • sequence-specific DNA binding; • DNA binding; • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific; • GO:0001144, GO:0001142, GO:0001143 mitochondrial transcription factor activity; • transcription coregulator binding; • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding; • transcription factor binding;
Componente celular	• membrane; • cariolinfa; • citosol; • citoplasma; • núcleo celular; • mitocôndria; • mitochondrial outer membrane; • matriz mitocondrial; • GO:0009327 complexo macromolecular;
Processo biológico	• initiation of primordial ovarian follicle growth; • ovulation from ovarian follicle; • GO:0009373 regulation of transcription, DNA-templated; • antral ovarian follicle growth; • positive regulation of erythrocyte differentiation; • glucose homeostasis; • DNA damage response, signal transduction by p53 class mediator; • tumor necrosis factor-mediated signaling pathway; • GO:1904489 regulation of reactive oxygen species metabolic process; • transcription by RNA polymerase II; • regulation of neural precursor cell proliferation; • transcription, DNA-templated; • neuronal stem cell population maintenance; • positive regulation of neuron apoptotic process; • oocyte maturation; • extrinsic apoptotic signaling pathway in absence of ligand; • positive regulation of apoptotic process; • regulation of translation; • negative regulation of canonical Wnt signaling pathway; • GO:0097285 apoptose; • GO:1901227 negative regulation of transcription by RNA polymerase II; • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • cellular response to oxidative stress; • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated; • positive regulation of reactive oxygen species biosynthetic process; • brain morphogenesis; • GO:0010260 envelhecimento; • negative regulation of neuron differentiation; • cellular response to hypoxia; • response to water-immersion restraint stress; • response to nutrient levels; • cellular response to amyloid-beta; • cellular response to corticosterone stimulus; • positive regulation of endothelial cell apoptotic process; • positive regulation of hydrogen peroxide-mediated programmed cell death; • response to dexamethasone; • cellular response to nerve growth factor stimulus; • cellular response to glucose stimulus; • anatomical structure morphogenesis; • cytokine-mediated signaling pathway; • mitochondrial transcription; • negative regulation of cell migration; • GO:1901047 insulin receptor signaling pathway; • positive regulation of autophagy; • positive regulation of muscle atrophy; • response to starvation;
	Sources:Amigo / QuickGO
Padrão de expressão RNA
	; ; ; ;
	Mais dados de referência de expressão
Ortólogos
	2309
	n/a
	ENSG00000118689
	n/a
	O43524
	n/a
	NM_001455; NM_201559
	n/a
	NP_001446; NP_963853
	n/a
	Wikidata
Ver/Editar Humano

FOXO3 ou FOXO3a é uma proteína que em humanos é codificada pelo gene FOXO3.^[2]

Factos rápidos Estruturas disponíveis, PDB ...

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FOXO3 pertence à subclasse O da família forkhead (cabeça do garfo) de fatores de transcrição que são caracterizados por um domínio distinto de ligação ao DNA da forkhead.^[3]

A desregulação da FOXO3a está envolvida na tumorigênese,^[4] for por exemplo, a translocação desse gene com o gene MLL está associada à leucemia aguda secundária. Alternativamente, variantes transcritas processadas que codificam a mesma proteína foram observadas.^[5]

[1]
«Human PubMed Reference:»
[2]
Anderson MJ, Viars CS, Czekay S, Cavenee WK, Arden KC (janeiro de 1998). «Cloning and characterization of three human forkhead genes that comprise an FKHR-like gene subfamily». Genomics. 47 (2): 187–99. PMID 9479491. doi:10.1006/geno.1997.5122
[3]
Brunet A, Bonni A, Zigmond MJ, Lin MZ, Juo P, Hu LS, Anderson MJ, Arden KC, Blenis J, Greenberg ME (março de 1999). «Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor». Cell. 96 (6): 857–68. PMID 10102273. doi:10.1016/S0092-8674(00)80595-4
[4]
Myatt SS, Lam EW (novembro de 2007). «The emerging roles of forkhead box (Fox) proteins in cancer». Nature Reviews. Cancer. 7 (11): 847–59. PMID 17943136. doi:10.1038/nrc2223
[5]
«Entrez Gene: FOXO3A forkhead box O3A»

Stahl M, Dijkers PF, Kops GJ, Lens SM, Coffer PJ, Burgering BM, Medema RH (maio de 2002). «The forkhead transcription factor FoxO regulates transcription of p27Kip1 and Bim in response to IL-2». Journal of Immunology. 168 (10): 5024–5031. PMID 11994454. doi:10.4049/jimmunol.168.10.5024
Morris BJ, Willcox DC, Donlon TA, Willcox BJ (março de 2015). «FOXO3: A Major Gene for Human Longevity – A Mini-Review». Gerontology. 61: 515–25. PMID 25832544. doi:10.1159/000375235
Kino T, Chrousos GP (junho de 2004). «Human immunodeficiency virus type-1 accessory protein Vpr: a causative agent of the AIDS-related insulin resistance/lipodystrophy syndrome?». Annals of the New York Academy of Sciences. 1024: 153–67. PMID 15265780. doi:10.1196/annals.1321.013
Hillion J, Le Coniat M, Jonveaux P, Berger R, Bernard OA (novembro de 1997). «AF6q21, a novel partner of the MLL gene in t(6;11)(q21;q23), defines a forkhead transcriptional factor subfamily». Blood. 90 (9): 3714–9. PMID 9345057
Anderson MJ, Viars CS, Czekay S, Cavenee WK, Arden KC (janeiro de 1998). «Cloning and characterization of three human forkhead genes that comprise an FKHR-like gene subfamily». Genomics. 47 (2): 187–99. PMID 9479491. doi:10.1006/geno.1997.5122
DaSilva L, Kirken RA, Taub DD, Evans GA, Duhé RJ, Bailey MA, Farrar WL (outubro de 1998). «Molecular cloning of FKHRL1P2, a member of the developmentally regulated fork head domain transcription factor family». Gene. 221 (1): 135–42. PMID 9852958. doi:10.1016/S0378-1119(98)00441-7
Brunet A, Bonni A, Zigmond MJ, Lin MZ, Juo P, Hu LS, Anderson MJ, Arden KC, Blenis J, Greenberg ME (março de 1999). «Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor». Cell. 96 (6): 857–68. PMID 10102273. doi:10.1016/S0092-8674(00)80595-4
Medema RH, Kops GJ, Bos JL, Burgering BM (abril de 2000). «AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1». Nature. 404 (6779): 782–7. PMID 10783894. doi:10.1038/35008115
Brunet A, Park J, Tran H, Hu LS, Hemmings BA, Greenberg ME (fevereiro de 2001). «Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a)». Molecular and Cellular Biology. 21 (3): 952–65. PMC 86685. PMID 11154281. doi:10.1128/MCB.21.3.952-965.2001
Schuur ER, Loktev AV, Sharma M, Sun Z, Roth RA, Weigel RJ (setembro de 2001). «Ligand-dependent interaction of estrogen receptor-alpha with members of the forkhead transcription factor family». The Journal of Biological Chemistry. 276 (36): 33554–60. PMID 11435445. doi:10.1074/jbc.M105555200
Kops GJ, Medema RH, Glassford J, Essers MA, Dijkers PF, Coffer PJ, Lam EW, Burgering BM (abril de 2002). «Control of cell cycle exit and entry by protein kinase B-regulated forkhead transcription factors». Molecular and Cellular Biology. 22 (7): 2025–36. PMC 133681. PMID 11884591. doi:10.1128/MCB.22.7.2025-2036.2002
Mahmud DL, G-Amlak M, Deb DK, Platanias LC, Uddin S, Wickrema A (fevereiro de 2002). «Phosphorylation of forkhead transcription factors by erythropoietin and stem cell factor prevents acetylation and their interaction with coactivator p300 in erythroid progenitor cells». Oncogene. 21 (10): 1556–62. PMID 11896584. doi:10.1038/sj.onc.1205230
Nadal A, Marrero PF, Haro D (agosto de 2002). «Down-regulation of the mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase gene by insulin: the role of the forkhead transcription factor FKHRL1». The Biochemical Journal. 366 (Pt 1): 289–97. PMC 1222772. PMID 12027802. doi:10.1042/BJ20020598
Wistow G, Bernstein SL, Wyatt MK, Fariss RN, Behal A, Touchman JW, Bouffard G, Smith D, Peterson K (junho de 2002). «Expressed sequence tag analysis of human RPE/choroid for the NEIBank Project: over 6000 non-redundant transcripts, novel genes and splice variants». Molecular Vision. 8: 205–20. PMID 12107410
Modur V, Nagarajan R, Evers BM, Milbrandt J (dezembro de 2002). «FOXO proteins regulate tumor necrosis factor-related apoptosis inducing ligand expression. Implications for PTEN mutation in prostate cancer». The Journal of Biological Chemistry. 277 (49): 47928–37. PMID 12351634. doi:10.1074/jbc.M207509200
Charvet C, Alberti I, Luciano F, Jacquel A, Bernard A, Auberger P, Deckert M (julho de 2003). «Proteolytic regulation of Forkhead transcription factor FOXO3a by caspase-3-like proteases». Oncogene. 22 (29): 4557–68. PMID 12881712. doi:10.1038/sj.onc.1206778
Crossley LJ (outubro de 2003). «Neutrophil activation by fMLP regulates FOXO (forkhead) transcription factors by multiple pathways, one of which includes the binding of FOXO to the survival factor Mcl-1». Journal of Leukocyte Biology. 74 (4): 583–92. PMID 12960271. doi:10.1189/jlb.0103020
Sunters A, Fernández de Mattos S, Stahl M, Brosens JJ, Zoumpoulidou G, Saunders CA, Coffer PJ, Medema RH, Coombes RC, Lam EW (dezembro de 2003). «FoxO3a transcriptional regulation of Bim controls apoptosis in paclitaxel-treated breast cancer cell lines». The Journal of Biological Chemistry. 278 (50): 49795–805. PMID 14527951. doi:10.1074/jbc.M309523200
Skurk C, Maatz H, Kim HS, Yang J, Abid MR, Aird WC, Walsh K (janeiro de 2004). «The Akt-regulated forkhead transcription factor FOXO3a controls endothelial cell viability through modulation of the caspase-8 inhibitor FLIP». The Journal of Biological Chemistry. 279 (2): 1513–25. PMID 14551207. doi:10.1074/jbc.M304736200
Dansen TB, Kops GJ, Denis S, Jelluma N, Wanders RJ, Bos JL, Burgering BM, Wirtz KW (janeiro de 2004). «Regulation of sterol carrier protein gene expression by the forkhead transcription factor FOXO3a». Journal of Lipid Research. 45 (1): 81–8. PMID 14563822. doi:10.1194/jlr.M300111-JLR200；chih长此人十二厂二

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[1] [1]
«Human PubMed Reference:»

[pmid9479491-2] [2]
Anderson MJ, Viars CS, Czekay S, Cavenee WK, Arden KC (janeiro de 1998). «Cloning and characterization of three human forkhead genes that comprise an FKHR-like gene subfamily». Genomics. 47 (2): 187–99. PMID 9479491. doi:10.1006/geno.1997.5122

[3] [3]
Brunet A, Bonni A, Zigmond MJ, Lin MZ, Juo P, Hu LS, Anderson MJ, Arden KC, Blenis J, Greenberg ME (março de 1999). «Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor». Cell. 96 (6): 857–68. PMID 10102273. doi:10.1016/S0092-8674(00)80595-4

[pmid17943136-4] [4]
Myatt SS, Lam EW (novembro de 2007). «The emerging roles of forkhead box (Fox) proteins in cancer». Nature Reviews. Cancer. 7 (11): 847–59. PMID 17943136. doi:10.1038/nrc2223

[entrez-5] [5]
«Entrez Gene: FOXO3A forkhead box O3A»

[2]

[1]

[3]

[4]

[5]

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FOXO3

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Função

Significado clínico

Referências

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