COX-3

COX-3 é uma recente descoberta de isoforma de ciclo-oxigenase, encontrada no cérebro, medula espinhal e coração. A estrutura química corresponde a da COX-1, exceto pelo íntron 1.^[1]

Foi sugerida por Daniel L. Simmons e sua equipe e acredita-se que este tipo esteja presente no sistema nervoso central devido os efeitos do paracetamol (provável inibidor mais seletivo desta forma) e não tanto de COX-2 e COX-1 na periferia.^[2]

Modula a dor e febre no SNC

[1]
Guía farmacológica de analgésicos
[2]
SCHELLACK, Gustav. Farmacologia na prática clínica da área de saúde. São Paulo: Fundamento Educacional, 2006

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COX-1

COX-2

[1] [1]
Guía farmacológica de analgésicos

[2] [2]
SCHELLACK, Gustav. Farmacologia na prática clínica da área de saúde. São Paulo: Fundamento Educacional, 2006

[1]

[2]

COX-3

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