Elotuzumab – lek biologiczny o działaniu immunosupresyjnym, obecnie (2012) w fazie badań klinicznych w terapii szpiczaka mnogiego, przeciwciała monoklonalne skierowane przeciwko receptorowi CS1 występującymi na powierzchni komórek szpiczaka mnogiego, receptory te są reprezentowane w minimalny sposób na innych komórkach organizmu[1]. Badania prowadzone są przez firmy Bristol-Myers Squibb i Abbott.
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- Badania kliniczne
- A Phase 1/2, Multi-center, Open-label, Dose-escalation Study of Elotuzumab(Humanized Anti-CS1 Monoclonal IgG1 Antibody) and Bortezomib in Subjects With Multiple Myeloma Following One to Three Prior Therapies., [w:] ClinicalTrials.gov [online], National Institutes of Health, NCT00726869 (ang.).
- Study of Elotuzumab in Combination With Lenalidomide and Dexamethasone in Subjects With Multiple Myeloma and Various Levels of Renal Function, [w:] ClinicalTrials.gov [online], National Institutes of Health, NCT01393964 (ang.).
- Biomarker Study of Elotuzumab in High Risk Smoldering Myeloma, [w:] ClinicalTrials.gov [online], National Institutes of Health, NCT01441973 (ang.).
- A Phase 1b/2, Dose-Escalation Study of Elotuzumab (Humanized Anti-CS1 Monoclonal IgG1 Antibody) in Relapsed Multiple Myeloma, [w:] ClinicalTrials.gov [online], National Institutes of Health, NCT00742560 (ang.).
- PH III Relapse or Refractory MM – Open Label With or Without Elotuzumab (ELOQUENT – 2), [w:] ClinicalTrials.gov [online], National Institutes of Health, NCT01239797 (ang.).
- Phase III Study of Lenalidomide and Dexamethasone With or Without Elotuzumab to Treat Newly Diagnosed, Previously Untreated Multiple Myeloma (ELOQUENT – 1), [w:] ClinicalTrials.gov [online], National Institutes of Health, NCT01335399 (ang.).
- Study of Bortezomib and Dexamethasone With or Without Elotuzumab to Treat Relapsed or Refractory Multiple Myeloma, [w:] ClinicalTrials.gov [online], National Institutes of Health, NCT01478048 (ang.).
- Phase I, Multi-Center, Open-Label, Dose Escalation Study of HuLuc63 in Subjects With Advanced Multiple Myeloma, [w:] ClinicalTrials.gov [online], National Institutes of Health, NCT00425347 (ang.).
