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Vrijthoff is een uit Heusden afkomstig geslacht waarvan leden sinds 1840 tot de Nederlandse adel behoren en dat in 1968 uitstierf. Het betreft een familie van horlogemakers in Maastricht en Den Haag in de zeventiende en achttiende eeuw, en van Nederlandse ambtenaren in de achttiende en negentiende eeuw.

Geschiedenis