Deze hits stonden in 2022 op nummer 1 in de 538 Top 50, de hitlijst van de Nederlandse radiozender Radio 538.
| Nummer | Datum | Artiest | Titel |
|---|---|---|---|
| 37 | 7 januari |  Kris Kross Amsterdam, Antoon & Sigourney K | Vluchtstrook |
| 14 januari | Kris Kross Amsterdam, Antoon & Sigourney K | Vluchtstrook | |
| 38 | 21 januari |  Tiësto & Ava Max | The Motto |
| 28 januari | Tiësto & Ava Max | The Motto | |
| 4 februari | Tiësto & Ava Max | The Motto | |
| 11 februari | Tiësto & Ava Max | The Motto | |
| 18 februari | Tiësto & Ava Max | The Motto | |
| 25 februari | Tiësto & Ava Max | The Motto | |
| 4 maart | Tiësto & Ava Max | The Motto | |
| 11 maart | Tiësto & Ava Max | The Motto | |
| 18 maart | Tiësto & Ava Max | The Motto | |
| 39 | 25 maart | Antoon | Hallo |
| 1 april | Antoon | Hallo | |
| 8 april | Antoon | Hallo | |
| 40 | 15 april |  Harry Styles | As It Was |
| 22 april | Harry Styles | As It Was | |
| 29 april | Harry Styles | As It Was | |
| 6 mei | Harry Styles | As It Was | |
| 13 mei | Harry Styles | As It Was | |
| 20 mei | Harry Styles | As It Was | |
| 27 mei | Harry Styles | As It Was | |
| 3 juni | Harry Styles | As It Was | |
| 10 juni | Harry Styles | As It Was | |
| 17 juni | Harry Styles | As It Was | |
| 24 juni | Harry Styles | As It Was | |
| 1 juli | Harry Styles | As It Was | |
| 8 juli | Harry Styles | As It Was | |
| 15 juli | Harry Styles | As It Was | |
| 22 juli | Harry Styles | As It Was | |
| 29 juli | Harry Styles | As It Was | |
| 5 augustus | Harry Styles | As It Was | |
| 12 augustus | Harry Styles | As It Was | |
| 19 augustus | Harry Styles | As It Was | |
| 26 augustus | Harry Styles | As It Was | |
| 41 | 2 september |  Rema | Calm Down |
| 9 september | Rema | Calm Down | |
| 42 | 16 september |  David Guetta & Bebe Rexha | I'm Good (Blue) |
| 23 september | David Guetta & Bebe Rexha | I'm Good (Blue) | |
| 2 oktober[1] | David Guetta & Bebe Rexha | I'm Good (Blue) | |
| 9 oktober | David Guetta & Bebe Rexha | I'm Good (Blue) | |
| 16 oktober | David Guetta & Bebe Rexha | I'm Good (Blue) | |
| 23 oktober | David Guetta & Bebe Rexha | I'm Good (Blue) | |
| 30 oktober | David Guetta & Bebe Rexha | I'm Good (Blue) | |
| 6 november | David Guetta & Bebe Rexha | I'm Good (Blue) | |
| 13 november | David Guetta & Bebe Rexha | I'm Good (Blue) | |
| 20 november | David Guetta & Bebe Rexha | I'm Good (Blue) | |
| 27 november | David Guetta & Bebe Rexha | I'm Good (Blue) | |
| 4 december | David Guetta & Bebe Rexha | I'm Good (Blue) | |
| 11 december | David Guetta & Bebe Rexha | I'm Good (Blue) | |
| 18 december | David Guetta & Bebe Rexha | I'm Good (Blue) | |
| 43 | 25 december | Claude | Ladada (Mon dernier mot) |
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