CXCL7

Ligan kemokin (motif C-X-C) 7 (CXCL7) ialah gen manusia.^[4] Protein terkod itu ialah sitokina kecil yang tergolong dalam keluarga kemokina CXC dan merupakan salah satu isobentuk protein Beta-Tromboglobulin atau protein asas pro-platelet (PPBP).^[5]

CXCL7
Struktur sedia ada PDB Pencarian ortolog: PDBe RCSB Senarai kod PDB 1TVX, 1F9P, 1NAP
Pengecam
Alias	PPBP, B-TG1, Beta-TG, CTAP-III, CTAP3, CTAPIII, CXCL7, LA-PF4, LDGF, MDGF, NAP-2, PBP, SCYB7, TC1, TC2, TGB, TGB1, THBGB, THBGB1, pro-platelet basic protein
Pengecam-pengecam luaran	OMIM: 121010 MGI: 1888712 HomoloGene: 136759 GeneCards: PPBP
Kedudukan gen (Manusia) Kr. Kromosom 4[1] Jalur 4q13.3 Mula 73,986,439 bp[1] Tamat 73,988,190 bp[1]
Corak ekspresi RNA Bgee Human Mouse (ortholog) Top expressed in monocyte trabecular bone granulocyte darah bone marrow cells periodontal fiber limpa decidua right lung Testis Top expressed in tibiofemoral joint Tali pusat darah limpa fetal liver hematopoietic progenitor cell body of femur right lung lobe janin endocardial cushion Kantung yolka More reference expression data BioGPS Rujukan lanjutan untuk data ekspresi
Ontologi gen Fungsi molekul growth factor activity cytokine activity glucose transmembrane transporter activity CXCR chemokine receptor binding chemokine activity Pengikatan protein plasma Komponen sel platelet alpha granule lumen extracellular region Ekstrasel tertiary granule lumen platelet alpha granule Proses biologi response to lipopolysaccharide regulation of cell population proliferation chemotaxis positive regulation of cell division platelet degranulation defense response to bacterium inflammatory response immune response chemokine-mediated signaling pathway defense response positive regulation of neutrophil chemotaxis antimicrobial humoral immune response mediated by antimicrobial peptide regulation of signaling receptor activity neutrophil degranulation cell chemotaxis G protein-coupled receptor signaling pathway glucose transmembrane transport neutrophil chemotaxis leukocyte chemotaxis cellular response to lipopolysaccharide Sumber:Amigo / QuickGO
Ortolog Spesies Manusia Mencit Entrez 5473 57349 Ensembl ENSG00000163736 ENSMUSG00000029372 UniProt P02775 Q9EQI5 RefSeq (mRNA) NM_002704 NM_023785 RefSeq (protein) NP_002695 NP_076274 Kedudukan (UCSC) Chr 4: 73.99 – 73.99 Mb tiada data Carian PubMed [2] [3]
Wikidata
Papar/Sunting data manusia Papar/Sunting data mencit

CXCL7 ialah protein yang dibebaskan pada jumlah yang besar oleh platelet, selepas pengaktifannya.^[6] Ia merangsangkan berbagai-bagai proses, termasuk: ^[7][8]

• mitogenesis;
• metabolisme glukosa;
• sintesis matriks luar sel; dan
• sinthesis pengaktif plasminogen.

Rujukan

1. GRCh38: Ensembl release 89: ENSG00000163736 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Entrez Gene: PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)".
5. Hristov M, Zernecke A, Bidzhekov K; dll. (2007). "Importance of CXC chemokine receptor 2 in the homing of human peripheral blood endothelial progenitor cells to sites of arterial injury". Circ. Res. 100 (4): 590–7. doi:10.1161/01.RES.0000259043.42571.68. PMID 17272812. Unknown parameter |month= ignored (bantuan); Explicit use of et al. in: |author= (bantuan)CS1 maint: multiple names: authors list (link)
6. Majumdar S, Gonder D, Koutsis B, Poncz M (1991). "Characterization of the human beta-thromboglobulin gene. Comparison with the gene for platelet factor 4". J Biol Chem. 266 (9): 5785–9. PMID 1826003.CS1 maint: multiple names: authors list (link)
7. Castor C, Miller J, Walz D (1983). "Structural and biological characteristics of connective tissue activating peptide (CTAP-III), a major human platelet-derived growth factor". Proc Natl Acad Sci USA. 80 (3): 765–9. doi:10.1073/pnas.80.3.765. PMID 6572368.CS1 maint: multiple names: authors list (link)
8. Castor C, Furlong A, Carter-Su C (1985). "Connective tissue activation: stimulation of glucose transport by connective tissue activating peptide III". Biochemistry. 24 (7): 1762–7. doi:10.1021/bi00328a029. PMID 4005226.CS1 maint: multiple names: authors list (link)

Templat:Pemodulat reseptor kemokin