ホスファチジルイノシトール-3,4,5-三リン酸-5-ホスファターゼ(Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase、EC 3.1.3.86)は、1-ホスファチジル-1D-ミオイノシトール-3,4,5-三リン酸-5-ホスファターゼ(1-phosphatidyl-1D-myo-inositol-3,4,5-trisphosphate 5-phosphohydrolase)という系統名を持つ酵素である[1][2][3][4][5]。以下の化学反応を触媒する。
- 1-ホスファチジル-1D-ミオイノシトール-3,4,5-三リン酸 + 水
1-ホスファチジル-1D-ミオイノシトール-3,4-二リン酸 + リン酸
Lioubin, M.N., Algate, P.A., Tsai, S., Carlberg, K., Aebersold, A. and Rohrschneider, L.R. (1996). “p150Ship, a signal transduction molecule with inositol polyphosphate-5-phosphatase activity”. Genes Dev. 10: 1084–1095. doi:10.1101/gad.10.9.1084. PMID 8654924. Damen, J.E., Liu, L., Rosten, P., Humphries, R.K., Jefferson, A.B., Majerus, P.W. and Krystal, G. (1996). “The 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3,4,5-triphosphate 5-phosphatase”. Proc. Natl. Acad. Sci. USA 93: 1689–1693. doi:10.1073/pnas.93.4.1689. PMC 40003. PMID 8643691. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC40003/. Giuriato, S., Payrastre, B., Drayer, A.L., Plantavid, M., Woscholski, R., Parker, P., Erneux, C. and Chap, H. (1997). “Tyrosine phosphorylation and relocation of SHIP are integrin-mediated in thrombin-stimulated human blood platelets”. J. Biol. Chem. 272: 26857–26863. doi:10.1074/jbc.272.43.26857. PMID 9341117. Drayer, A.L., Pesesse, X., De Smedt, F., Woscholski, R., Parker, P. and Erneux, C. (1996). “Cloning and expression of a human placenta inositol 1,3,4,5-tetrakisphosphate and phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase”. Biochem. Biophys. Res. Commun. 225: 243–249. doi:10.1006/bbrc.1996.1161. PMID 8769125. Pesesse, X., Moreau, C., Drayer, A.L., Woscholski, R., Parker, P. and Erneux, C. (1998). “The SH2 domain containing inositol 5-phosphatase SHIP2 displays phosphatidylinositol 3,4,5-trisphosphate and inositol 1,3,4,5-tetrakisphosphate 5-phosphatase activity”. FEBS Lett. 437 (3): 301–303. doi:10.1016/S0014-5793(98)01255-1. PMID 9824312.
