ペプチド性メチオニン(R)-S-オキシドレダクターゼ

ペプチド性メチオニン(R)-S-オキシドレダクターゼ（peptide-methionine (R)-S-oxide reductase）は、次の化学反応を触媒する酸化還元酵素である。

ペプチド-L-メチオニン + チオレドキシンジスルフィド + H₂O ${\displaystyle \rightleftharpoons }$ ペプチド-L-メチオニン-(R)-S-オキシド + チオレドキシン

ペプチド性メチオニン(R)-S-オキシドレダクターゼ
識別子
EC番号	1.8.4.12
データベース
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB構造	RCSB PDB PDBj PDBe PDBsum
検索 PMC articles PubMed articles NCBI proteins

組織名はpeptide-methionine:thioredoxin-disulfide S-oxidoreductase [methionine (R)-S-oxide-forming]で、別名にMsrB; methionine sulfoxide reductase (ambiguous); pMSR; methionine S-oxide reductase (ambiguous); selenoprotein R; methionine S-oxide reductase (R-form oxidizing); methionine sulfoxide reductase B; SelR; SelX; PilB; pRMsrがある。

参考文献

• Moskovitz, J., Singh, V.K., Requena, J., Wilkinson, B.J., Jayaswal, R.K. and Stadtman, E.R. (2002). “Purification and characterization of methionine sulfoxide reductases from mouse and Staphylococcus aureus and their substrate stereospecificity.”. Biochem. Biophys. Res. Commun. 290: 62-65. PMID 11779133.
• Taylor, A.B., Benglis, D.M., Jr., Dhandayuthapani, S. and Hart, P.J. (2003). “Structure of Mycobacterium tuberculosis methionine sulfoxide reductase A in complex with protein-bound methionine.”. J. Bacteriol. 185: 4119-4126. PMID 12837786.
• Singh, V.K. and Moskovitz, J. (2003). “Multiple methionine sulfoxide reductase genes in Staphylococcus aureus: expression of activity and roles in tolerance of oxidative stress.”. Microbiology 149: 2739-2747. PMID 14523107.
• Boschi-Muller, S., Olry, A., Antoine, M. and Branlant, G. (2005). “The enzymology and biochemistry of methionine sulfoxide reductases.”. Biochim. Biophys. Acta 1703: 231-238. PMID 15680231.
• Ezraty, B., Aussel, L. and Barras, F. (2005). “Methionine sulfoxide reductases in prokaryotes.”. Biochim. Biophys. Acta 1703: 221-229. PMID 15680230.
• Weissbach, H., Resnick, L. and Brot, N. (2005). “Methionine sulfoxide reductases: history and cellular role in protecting against oxidative damage.”. Biochim. Biophys. Acta 1703: 203-212. PMID 15680228.
• Kauffmann, B., Aubry, A. and Favier, F. (2005). “The three-dimensional structures of peptide methionine sulfoxide reductases: current knowledge and open questions.”. Biochim. Biophys. Acta 1703: 249-260. PMID 15680233.
• Vougier, S., Mary, J. and Friguet, B. (2003). “Subcellular localization of methionine sulphoxide reductase A (MsrA): evidence for mitochondrial and cytosolic isoforms in rat liver cells.”. Biochem. J. 373: 531-537. PMID 12693988.
• Olry, A., Boschi-Muller, S., Marraud, M., Sanglier-Cianferani, S., Van Dorsselear, A. and Branlant, G. (2002). “Characterization of the methionine sulfoxide reductase activities of PILB, a probable virulence factor from Neisseria meningitidis.”. J. Biol. Chem. 277: 12016-12022. PMID 11812798.
• Boschi-Muller, S., Olry, A., Antoine, M. and Branlant, G. (2005). “The enzymology and biochemistry of methionine sulfoxide reductases.”. Biochim. Biophys. Acta 1703: 231-238. PMID 15680231.
• Brot, N., Weissbach, L., Werth, J. and Weissbach, H. (1981). “Enzymatic reduction of protein-bound methionine sulfoxide.”. Proc. Natl. Acad. Sci. USA 78: 2155-2158. PMID 7017726.