NDC1

ヌクレオポリンNDC1（英語: Nucleoporin NDC1）は、ヒトにおいてTMEM48 遺伝子にコードされているタンパク質である^[5][6][7]。核膜孔複合体にアラジン（英語版）を固定する^[8]。　

NDC1
識別子
記号	NDC1, NET3, TMEM48, NDC1 transmembrane nucleoporin
外部ID	OMIM: 610115 MGI: 1920037 HomoloGene: 41224 GeneCards: NDC1
遺伝子の位置 (ヒト) 染色体 1番染色体 (ヒト)[1] バンド データ無し 開始点 53,765,478 bp[1] 終点 53,838,463 bp[1]
遺伝子の位置 (マウス) 染色体 4番染色体 (マウス)[2] バンド データ無し 開始点 107,224,981 bp[2] 終点 107,273,543 bp[2]
RNA発現パターン さらなる参照発現データ
遺伝子オントロジー 分子機能 • structural constituent of nuclear pore 細胞の構成要素 • 細胞質 • integral component of membrane • 核膜 • nuclear envelope • 膜 • 細胞膜 • 核膜孔 • actin cytoskeleton • 細胞核 • スピンドル極体 • nuclear pore transmembrane ring • 宿主細胞 生物学的プロセス • mRNA transport • nuclear pore complex assembly • viral transcription • protein sumoylation • mitotic nuclear membrane disassembly • homologous chromosome pairing at meiosis • 精子形成 • タンパク質輸送 • regulation of cellular response to heat • viral process • mRNA export from nucleus • intracellular transport of virus • tRNA export from nucleus • spindle pole body duplication • regulation of gene silencing by miRNA • regulation of glycolytic process • 輸送 • nuclear pore organization 出典:Amigo / QuickGO
オルソログ
種	ヒト	マウス
Entrez	55706	72787
Ensembl	ENSG00000058804	ENSMUSG00000028614
UniProt	Q9BTX1	Q8VCB1
RefSeq (mRNA)	NM_001168551 NM_018087	NM_028355
RefSeq (タンパク質)	NP_001162023 NP_060557	NP_082631
場所 (UCSC)	Chr 1: 53.77 – 53.84 Mb	Chr 1: 107.22 – 107.27 Mb
PubMed検索	[3]	[4]
ウィキデータ
閲覧/編集 ヒト 閲覧/編集 マウス

出典

1. GRCh38: Ensembl release 89: ENSG00000058804 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028614 - Ensembl, May 2017
3. Human PubMed Reference:
4. Mouse PubMed Reference:
5. “Topology of yeast Ndc1p: predictions for the human NDC1/NET3 homologue”. Anat Rec A Discov Mol Cell Evol Biol 288 (7): 681–94. (Aug 2006). doi:10.1002/ar.a.20335. PMC 3049984. PMID 16779818. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3049984/.
6. “Nuclear membrane proteins with potential disease links found by subtractive proteomics”. Science 301 (5638): 1380–2. (Sep 2003). doi:10.1126/science.1088176. PMID 12958361.
7. “Entrez Gene: TMEM48 transmembrane protein 48”. 2019年7月23日閲覧。
8. Kind, Barbara; Koehler, Katrin; Lorenz, Mike; Huebner, Angela (December 2009). “The nuclear pore complex protein ALADIN is anchored via NDC1 but not via POM121 and GP210 in the nuclear envelope”. Biochemical and Biophysical Research Communications 390 (2): 205–210. doi:10.1016/j.bbrc.2009.09.080.

参考文献

• “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. (2003). doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241/.
• “Complete sequencing and characterization of 21,243 full-length human cDNAs.”. Nat. Genet. 36 (1): 40–5. (2004). doi:10.1038/ng1285. PMID 14702039.
• “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res. 14 (10B): 2121–7. (2004). doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC528928/.
• “Phosphoproteome analysis of the human mitotic spindle.”. Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. (2006). doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1459365/.
• “The conserved transmembrane nucleoporin NDC1 is required for nuclear pore complex assembly in vertebrate cells.”. Mol. Cell 22 (1): 93–103. (2006). doi:10.1016/j.molcel.2006.02.015. PMID 16600873.
• “NDC1: a crucial membrane-integral nucleoporin of metazoan nuclear pore complexes.”. J. Cell Biol. 173 (4): 509–19. (2006). doi:10.1083/jcb.200601001. PMC 2063861. PMID 16702233. http://pubman.mpdl.mpg.de/pubman/item/escidoc:596272/component/escidoc:596271/298064.pdf.
• “The DNA sequence and biological annotation of human chromosome 1.”. Nature 441 (7091): 315–21. (2006). doi:10.1038/nature04727. PMID 16710414.
• “Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.”. Cell 127 (3): 635–48. (2006). doi:10.1016/j.cell.2006.09.026. PMID 17081983.