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senyawa kimia Dari Wikipedia, ensiklopedia bebas
Ergotamin adalah obat yang digunakan untuk meredakan atau mencegah migrain. Obat ergotamin biasanya dapat ditemukan dalam produk obat yang dikombinasikan dengan kafein. Obat ergotamin merupakan vasokonstriktor agonis adrenergik selektif alfa-1.[4][5]
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Nama sistematis (IUPAC) | |
(6aR,9R)-N-((2R,5S,10aS,10bS)-5-Benzyl-10b-hydroxy-2-methyl-3,6-dioxooctahydro-2H-oxazolo[3,2-a]pyrrolo[2,1-c]pyrazin-2-yl)-7-methyl-4,6,6a,7,8,9-hexahydroindolo[4,3-fg]quinoline-9-carboxamide | |
Data klinis | |
Nama dagang | Cafergot (with caffeine), Ergomar, others |
AHFS/Drugs.com | monograph |
Kat. kehamilan | X(US) |
Status hukum | Harus dengan resep dokter (S4) (AU) Schedule VI (CA) POM (UK) ℞-only (US) |
Rute | Oral |
Data farmakokinetik | |
Bioavailabilitas | Intravenous: 100%,[1] Intramuscular: 47%,[2] Oral: <1%[3] (Enhanced by co-administration of caffeine[1]) |
Metabolisme | Hepatic[2] |
Waktu paruh | 2 hours[2] |
Ekskresi | 90% biliary[2] |
Pengenal | |
Nomor CAS | 113-15-5 ![]() |
Kode ATC | N02CA02 |
PubChem | CID 8223 |
Ligan IUPHAR | 149 |
DrugBank | DB00696 |
ChemSpider | 7930 ![]() |
UNII | PR834Q503T ![]() |
KEGG | D07906 ![]() |
ChEBI | CHEBI:64318 ![]() |
ChEMBL | CHEMBL442 ![]() |
Sinonim | 2'-Methyl-5'α-benzyl-12'-hydroxy-3',6',18-trioxoergotaman; 9,10α-Dihydro-12'-hydroxy-2'-methyl-5'α-(phenylmethyl)ergotaman-3',6',18-trione |
Data kimia | |
Rumus | C33H35N5O5 |
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