La pendrine intervient également dans les cellules de la thyroïde, où elle est présente au pôle apical en contact avec le follicule thyroïdien, qui contient la colloïde. Sa fonction est de permettre aux ions iodure I− de franchir la membrane apicale des cellules folliculaire en direction de la colloïde, où ils sont oxydés en diiodeI2 par la thyroperoxydase: cette fonction est indispensable à la biosynthèse des hormones thyroïdiennes.
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