برویکن

پروتئین اصلی بـِرِویکَـن (انگلیسی: Brevican core protein) یا به‌اختصار «بـِرِویکَـن» پروتئینی است که در انسان توسط ژنِ «BCAN» (بی‌کَن) کُد می‌شود.^[4][5][6]

BCAN
معین‌کننده‌ها
نام‌های دیگر	BCAN, BEHAB, CSPG7, Brevican
شناسه‌های بیرونی	OMIM: 600347 MGI: 1096385 HomoloGene: 7244 GeneCards: BCAN
موقعیت ژن (موش) کروموزوم کروموزوم ۳ (موش)[1] نوار 3 F1|3 38.78 cM شروع 87,987,531 bp[1] پایان 88,000,230 bp[1]
الگوی گسترش RNA More reference expression data
هستی‌شناسی ژن عملکرد ملکولی • hyaluronic acid binding • carbohydrate binding • extracellular matrix structural constituent ترکیبات سلولی • membrane • extracellular region • lysosomal lumen • Golgi lumen • anchored component of membrane • GO:0005578 بافت‌مانه برون‌یاخته‌ای • glutamatergic synapse فرایند زیستی • skeletal system development • chondroitin sulfate biosynthetic process • extracellular matrix organization • central nervous system development • chondroitin sulfate catabolic process • dermatan sulfate biosynthetic process • hippocampus development • چسبندگی سلولی • synapse maturation منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
گونه‌ها	انسان	موش
Entrez	63827	12032
آنسامبل	ENSG00000132692	ENSMUSG00000004892
یونی‌پروت	Q96GW7	Q61361
RefSeq (mRNA)	NM_021948، NM_198427، XM_017002047 XM_011509866، NM_021948، NM_198427، XM_017002047	NM_007529، XM_006500936، XM_006500937، XM_030252396 NM_001109758، NM_007529، XM_006500936، XM_006500937، XM_030252396
RefSeq (پروتئین)	NP_940819، XP_011508168، XP_016857536 NP_068767، NP_940819، XP_011508168، XP_016857536	NP_031555، XP_006500999، XP_006501000، XP_030108256، XP_036018756، XP_036018757، XP_036018758 NP_001103228، NP_031555، XP_006500999، XP_006501000، XP_030108256، XP_036018756، XP_036018757، XP_036018758
موقعیت (UCSC)	ن/م	Chr : 87.99 – 88 Mb
جستجوی PubMed	[2]	[3]
ویکی‌داده
مشاهده/ویرایش انسان مشاهده/ویرایش موش

این پروتئین بر سطحِ سلول‌های عصبی در مغز قرار گرفته‌است.^[7] در سلول‌های ملانوسیتی، بیان ژنِ بی‌کَن توسط MITF تنظیم می‌شود.^[8]

منابع

1. GRCm38: Ensembl release 89: ENSMUSG00000004892 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Gary SC, Zerillo CA, Chiang VL, Gaw JU, Gray G, Hockfield S (Oct 2000). "cDNA cloning, chromosomal localization, and expression analysis of human BEHAB/brevican, a brain specific proteoglycan regulated during cortical development and in glioma". Gene. 256 (1–2): 139–47. doi:10.1016/S0378-1119(00)00362-0. PMID 11054543.
5. Nomoto H, Oohashi T, Hirakawa S, Ueki Y, Ohtsuki H, Ninomiya Y (Feb 2002). "Human BRAL1 and BCAN genes that belong to the link-module superfamily are tandemly arranged on chromosome 1q21-23". Acta Medica Okayama. 56 (1): 25–9. PMID 11873941.
6. "Entrez Gene: BCAN brevican".
7. Frischknecht R, Seidenbecher CI (Jul 2012). "Brevican: a key proteoglycan in the perisynaptic extracellular matrix of the brain". The International Journal of Biochemistry & Cell Biology. 44 (7): 1051–4. doi:10.1016/j.biocel.2012.03.022. PMID 22537913.
8. Hoek KS, Schlegel NC, Eichhoff OM, Widmer DS, Praetorius C, Einarsson SO, Valgeirsdottir S, Bergsteinsdottir K, Schepsky A, Dummer R, Steingrimsson E (Dec 2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell & Melanoma Research. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971.

• مشارکت‌کنندگان ویکی‌پدیا. «Brevican». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۲۲ دسامبر ۲۰۱۷.

بیشتر بخوانید

• Hu B, Kong LL, Matthews RT, Viapiano MS (Sep 2008). "The proteoglycan brevican binds to fibronectin after proteolytic cleavage and promotes glioma cell motility". The Journal of Biological Chemistry. 283 (36): 24848–59. doi:10.1074/jbc.M801433200. PMC 3259830. PMID 18611854.
• Seidenbecher CI, Richter K, Rauch U, Fässler R, Garner CC, Gundelfinger ED (Nov 1995). "Brevican, a chondroitin sulfate proteoglycan of rat brain, occurs as secreted and cell surface glycosylphosphatidylinositol-anchored isoforms". The Journal of Biological Chemistry. 270 (45): 27206–12. doi:10.1074/jbc.270.45.27206. PMID 7592978.
• Aspberg A, Miura R, Bourdoulous S, Shimonaka M, Heinegârd D, Schachner M, Ruoslahti E, Yamaguchi Y (Sep 1997). "The C-type lectin domains of lecticans, a family of aggregating chondroitin sulfate proteoglycans, bind tenascin-R by protein-protein interactions independent of carbohydrate moiety". Proceedings of the National Academy of Sciences of the United States of America. 94 (19): 10116–21. doi:10.1073/pnas.94.19.10116. PMC 23322. PMID 9294172.
• Nakamura H, Fujii Y, Inoki I, Sugimoto K, Tanzawa K, Matsuki H, Miura R, Yamaguchi Y, Okada Y (Dec 2000). "Brevican is degraded by matrix metalloproteinases and aggrecanase-1 (ADAMTS4) at different sites". The Journal of Biological Chemistry. 275 (49): 38885–90. doi:10.1074/jbc.M003875200. PMID 10986281.
• Olin AI, Mörgelin M, Sasaki T, Timpl R, Heinegård D, Aspberg A (Jan 2001). "The proteoglycans aggrecan and Versican form networks with fibulin-2 through their lectin domain binding". The Journal of Biological Chemistry. 276 (2): 1253–61. doi:10.1074/jbc.M006783200. PMID 11038354.
• Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A (Oct 2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Research. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Xu XM, Chen Y, Chen J, Yang S, Gao F, Underhill CB, Creswell K, Zhang L (Sep 2003). "A peptide with three hyaluronan binding motifs inhibits tumor growth and induces apoptosis". Cancer Research. 63 (18): 5685–90. PMID 14522884.
• Bekku Y, Su WD, Hirakawa S, Fässler R, Ohtsuka A, Kang JS, Sanders J, Murakami T, Ninomiya Y, Oohashi T (Sep 2003). "Molecular cloning of Bral2, a novel brain-specific link protein, and immunohistochemical colocalization with brevican in perineuronal nets". Molecular and Cellular Neurosciences. 24 (1): 148–59. doi:10.1016/S1044-7431(03)00133-7. PMID 14550776.
• Dong Y, Han X, Xue Y, Dong B, Guo X, Hu G, Zhu C, Lu Y (Feb 2004). "Secreted brevican mRNA is expressed in the adult rat pituitary". Biochemical and Biophysical Research Communications. 314 (3): 745–8. doi:10.1016/j.bbrc.2003.12.151. PMID 14741698.
• Viapiano MS, Bi WL, Piepmeier J, Hockfield S, Matthews RT (Aug 2005). "Novel tumor-specific isoforms of BEHAB/brevican identified in human malignant gliomas". Cancer Research. 65 (15): 6726–33. doi:10.1158/0008-5472.CAN-05-0585. PMID 16061654.
• Nakada M, Miyamori H, Kita D, Takahashi T, Yamashita J, Sato H, Miura R, Yamaguchi Y, Okada Y (Sep 2005). "Human glioblastomas overexpress ADAMTS-5 that degrades brevican". Acta Neuropathologica. 110 (3): 239–46. doi:10.1007/s00401-005-1032-6. PMID 16133547.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.