CDH3

کادهرین-۳ (انگلیسی: Cadherin-3) که با نام پی-کادهرین هم شناخته می‌شود، یک پروتئین است که در انسان توسط ژن «CDH3» کدگذاری می‌شود.^[4][5]

CDH3
ساختارهای موجود PDB جستجوی هم‌ساخت‌شناسی: PDBe RCSB فهرست شناسه‌های PDB 4OY9
معین‌کننده‌ها
نام‌های دیگر	CDH3, CDHP, HJMD, PCAD, cadherin 3
شناسه‌های بیرونی	OMIM: 114021 MGI: 88356 HomoloGene: 20425 GeneCards: CDH3
موقعیت ژن (موش) کروموزوم کروموزوم ۸ (موش)[1] نوار 8 D3|8 53.16 cM شروع 107,237,523 bp[1] پایان 107,283,929 bp[1]
الگوی گسترش RNA More reference expression data
هستی‌شناسی ژن عملکرد ملکولی • calcium ion binding • metal ion binding • molecular function • cytoskeletal protein binding • protein homodimerization activity • cadherin binding ترکیبات سلولی • سیتوپلاسم • integral component of membrane • membrane • پوسته یاخته • cell surface • catenin complex فرایند زیستی • hair cycle process • positive regulation of keratinocyte proliferation • negative regulation of timing of catagen • response to stimulus • keratinization • بهبود زخم • regulation of hair cycle by canonical Wnt signaling pathway • negative regulation of transforming growth factor beta2 production • positive regulation of tyrosinase activity • retina homeostasis • GO:1901313 positive regulation of gene expression • چسبندگی سلولی • positive regulation of insulin-like growth factor receptor signaling pathway • canonical Wnt signaling pathway • positive regulation of melanin biosynthetic process • positive regulation of melanosome transport • adherens junction organization • بینایی • homophilic cell adhesion via plasma membrane adhesion molecules • cell-cell adhesion • positive regulation of canonical Wnt signaling pathway • cell-cell junction assembly • calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules • cell-cell adhesion mediated by cadherin • GO:0000767 cell morphogenesis منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
گونه‌ها	انسان	موش
Entrez	1001	12560
آنسامبل	ENSG00000062038	ENSMUSG00000061048
یونی‌پروت	P22223	P10287
RefSeq (mRNA)	NM_001793، NM_001317195، NM_001317196، XM_047433450 XM_011522800، NM_001793، NM_001317195، NM_001317196، XM_047433450	NM_007665 NM_001037809، NM_007665
RefSeq (پروتئین)	NP_001304125، NP_001784، XP_011521102 NP_001304124، NP_001304125، NP_001784، XP_011521102	NP_031691 NP_001032898، NP_031691
موقعیت (UCSC)	ن/م	Chr : 107.24 – 107.28 Mb
جستجوی PubMed	[2]	[3]
ویکی‌داده
مشاهده/ویرایش انسان مشاهده/ویرایش موش

جهش در این ژن با بروز «کم‌مویی مادرزادی به‌همراه دیستروفی لکه زرد نوجوانی» در ارتباط است.^[5]

جستارهای وابسته

• AMFR
• ANKH
• CD81
• C9orf72
• AMBP

منابع

1. GRCm38: Ensembl release 89: ENSMUSG00000061048 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Kaupmann K, Becker-Follmann J, Scherer G, Jockusch H, Starzinski-Powitz A (Oct 1992). "The gene for the cell adhesion molecule M-cadherin maps to mouse chromosome 8 and human chromosome 16q24.1-qter and is near the E-cadherin (uvomorulin) locus in both species". Genomics. 14 (2): 488–90. doi:10.1016/S0888-7543(05)80247-2. PMID 1427864.
5. "Entrez Gene: CDH3 cadherin 3, type 1, P-cadherin (placental)".

• مشارکت‌کنندگان ویکی‌پدیا. «CDH3 (gene)». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۲۰ ژوئیه ۲۰۱۸.

بیشتر بخوانید

• Herrenknecht K, Ozawa M, Eckerskorn C, Lottspeich F, Lenter M, Kemler R (Oct 1991). "The uvomorulin-anchorage protein alpha catenin is a vinculin homologue". Proceedings of the National Academy of Sciences of the United States of America. 88 (20): 9156–60. doi:10.1073/pnas.88.20.9156. PMC 52671. PMID 1924379.
• Shimoyama Y, Hirohashi S, Hirano S, Noguchi M, Shimosato Y, Takeichi M, Abe O (Apr 1989). "Cadherin cell-adhesion molecules in human epithelial tissues and carcinomas". Cancer Research. 49 (8): 2128–33. PMID 2702654.
• Shimoyama Y, Yoshida T, Terada M, Shimosato Y, Abe O, Hirohashi S (Oct 1989). "Molecular cloning of a human Ca2+-dependent cell-cell adhesion molecule homologous to mouse placental cadherin: its low expression in human placental tissues". The Journal of Cell Biology. 109 (4 Pt 1): 1787–94. doi:10.1083/jcb.109.4.1787. PMC 2115800. PMID 2793940.
• Palacios J, Benito N, Pizarro A, Suárez A, Espada J, Cano A, Gamallo C (Mar 1995). "Anomalous expression of P-cadherin in breast carcinoma. Correlation with E-cadherin expression and pathological features". The American Journal of Pathology. 146 (3): 605–12. PMC 1869170. PMID 7534041.
• van der Linden PJ, de Goeij AF, Dunselman GA, Erkens HW, Evers JL (Jun 1995). "Expression of cadherins and integrins in human endometrium throughout the menstrual cycle". Fertility and Sterility. 63 (6): 1210–6. doi:10.1016/s0015-0282(16)57599-2. PMID 7538474.
• Tang A, Eller MS, Hara M, Yaar M, Hirohashi S, Gilchrest BA (Apr 1994). "E-cadherin is the major mediator of human melanocyte adhesion to keratinocytes in vitro". Journal of Cell Science. 107 (4): 983–92. PMID 8056851.
• Tassin MT, Beziau A, Gubler MC, Boyer B (Mar 1994). "Spatiotemporal expression of molecules associated with junctional complexes during the in vivo maturation of renal podocytes". The International Journal of Developmental Biology. 38 (1): 45–54. PMID 8074995.
• Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Navarro P, Lozano E, Cano A (Aug 1993). "Expression of E- or P-cadherin is not sufficient to modify the morphology and the tumorigenic behavior of murine spindle carcinoma cells. Possible involvement of plakoglobin". Journal of Cell Science. 105 (4): 923–34. PMID 8227214.
• Reynolds AB, Daniel JM, Mo YY, Wu J, Zhang Z (Jun 1996). "The novel catenin p120cas binds classical cadherins and induces an unusual morphological phenotype in NIH3T3 fibroblasts". Experimental Cell Research. 225 (2): 328–37. doi:10.1006/excr.1996.0183. PMID 8660921.
• Soler AP, Harner GD, Knudsen KA, McBrearty FX, Grujic E, Salazar H, Han AC, Keshgegian AA (Aug 1997). "Expression of P-cadherin identifies prostate-specific-antigen-negative cells in epithelial tissues of male sexual accessory organs and in prostatic carcinomas. Implications for prostate cancer biology". The American Journal of Pathology. 151 (2): 471–8. PMC 1858007. PMID 9250159.
• Wakita H, Furukawa F, Baba S, Takigawa M (Nov 1997). "Human squamous-cell-carcinoma cell line (DJM-1) cells synthesize P-cadherin molecules via an elevation of extracellular calcium: calcium regulates P-cadherin-gene expression at the translational level via protein tyrosine phosphorylation". International Journal of Cancer. 73 (3): 432–9. doi:10.1002/(SICI)1097-0215(19971104)73:3<432::AID-IJC19>3.0.CO;2-E. PMID 9359492.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Kremmidiotis G, Baker E, Crawford J, Eyre HJ, Nahmias J, Callen DF (May 1998). "Localization of human cadherin genes to chromosome regions exhibiting cancer-related loss of heterozygosity". Genomics. 49 (3): 467–71. doi:10.1006/geno.1998.5281. PMID 9615235.
• Jarrard DF, Paul R, van Bokhoven A, Nguyen SH, Bova GS, Wheelock MJ, Johnson KR, Schalken J, Bussemakers M, Isaacs WB (Nov 1997). "P-Cadherin is a basal cell-specific epithelial marker that is not expressed in prostate cancer". Clinical Cancer Research. 3 (11): 2121–8. PMID 9815605.
• Schmeiser K, Grand RJ (Apr 1999). "The fate of E- and P-cadherin during the early stages of apoptosis". Cell Death and Differentiation. 6 (4): 377–86. doi:10.1038/sj.cdd.4400504. PMID 10381631.
• Rufas O, Fisch B, Ziv S, Shalgi R (Feb 2000). "Expression of cadherin adhesion molecules on human gametes". Molecular Human Reproduction. 6 (2): 163–9. doi:10.1093/molehr/6.2.163. PMID 10655458.
• Klingelhöfer J, Troyanovsky RB, Laur OY, Troyanovsky S (Aug 2000). "Amino-terminal domain of classic cadherins determines the specificity of the adhesive interactions". Journal of Cell Science. 113 (16): 2829–36. PMID 10910767.
• Han AC, Edelson MI, Peralta Soler A, Knudsen KA, Lifschitz-Mercer B, Czernobilsky B, Rosenblum NG, Salazar H (Nov 2000). "Cadherin expression in glandular tumors of the cervix". Cancer. 89 (10): 2053–8. doi:10.1002/1097-0142(20001115)89:10<2053::AID-CNCR4>3.0.CO;2-C. PMID 11066045.
• Bauer K, Gosau M, Reinders J, Oefner P, Reichert TE, Bauer R (Nov 2013). "Presenilin 1/γ-secretase modulates P-cadherin processing and influences cell adhesion in oral squamous cell carcinoma cell lines". Carcinogenesis. 34 (11): 2622–8. doi:10.1093/carcin/bgt211. PMID 23740836.

پیوند به بیرون

• مکان ژن انسانی CDH3 در مرورگر ژنومی UCSC.
• جزئیات ژن انسانی CDH3 در مرورگر ژنومی UCSC.