HDAC3

HDAC3
ساختارهای موجود
PDB	جستجوی هم‌ساخت‌شناسی: PDBe RCSB
فهرست شناسه‌های PDB
	4A69
معین‌کننده‌ها
نام‌های دیگر	HDAC3, HD3, RPD3, RPD3-2, histone deacetylase 3
شناسه‌های بیرونی	OMIM: 605166 MGI: 1343091 HomoloGene: 48250 GeneCards: HDAC3
موقعیت ژن (موش)
کروموزوم	کروموزوم ۱۸ (موش)
پایان	38,088,069 bp
الگوی گسترش RNA
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• NAD-dependent histone deacetylase activity (H3-K14 specific); • GO:0001106 transcription corepressor activity; • histone deacetylase activity; • protein deacetylase activity; • transcription factor binding; • histone deacetylase binding; • chromatin binding; • NF-kappaB binding; • GO:0001948، GO:0016582 پیوند پروتئینی; • enzyme binding; • hydrolase activity; • cyclin binding;
ترکیبات سلولی	• سیتوپلاسم; • histone deacetylase complex; • سیتوزول; • دستگاه گلژی; • پوسته یاخته; • transcription repressor complex; • نوکلئوپلاسم; • spindle microtubule; • هسته یاخته; • mitotic spindle;
فرایند زیستی	• histone H3 deacetylation; • positive regulation of protein phosphorylation; • GO:0009373 regulation of transcription, DNA-templated; • regulation of protein stability; • negative regulation of apoptotic process; • GO:1901227 negative regulation of transcription by RNA polymerase II; • cellular response to fluid shear stress; • transcription, DNA-templated; • spindle assembly; • protein deacetylation; • negative regulation of JNK cascade; • ساعت زیستی; • negative regulation of myotube differentiation; • GO:0045996 negative regulation of transcription, DNA-templated; • histone deacetylation; • positive regulation of TOR signaling; • GO:0003257، GO:0010735، GO:1901228، GO:1900622، GO:1904488 positive regulation of transcription by RNA polymerase II; • negative regulation of nucleic acid-templated transcription; • regulation of lipid metabolic process; • GO:0031497، GO:0006336، GO:0034724، GO:0001301، GO:0007580، GO:0034652، GO:0010847 chromatin organization; • positive regulation of protein import into nucleus; • histone H4 deacetylation; • positive regulation of cold-induced thermogenesis; • positive regulation of protein ubiquitination; • circadian regulation of gene expression; • regulation of circadian rhythm; • rhythmic process;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	8841
	15183
	ENSG00000171720
	ENSMUSG00000024454
	O15379
	O88895
	NM_003883، XM_011537697 XR_944336، NM_003883، XM_011537697
	XR_385976 NM_010411، XR_385976
	NP_001341968، NP_001341969، NP_001341970 NP_003874، NP_001341968، NP_001341969، NP_001341970
	NP_034541
	ویکی‌داده
مشاهده/ویرایش انسان	مشاهده/ویرایش موش

هیستون دِاَستیلاز ۳ (انگلیسی: Histone deacetylase 3) یک پروتئین است که در انسان توسط ژن «HDAC3» کُدگذاری می‌شود.^[4]^[5]^[6]^[7]

اطلاعات اجمالی ساختارهای موجود, PDB ...

بستن

این پروتئین نقش بسیار مهمی در تنظیم رونویسی ژن‌ها، پیشرفتِ چرخهٔ سلولی و وقایع تکاملی سلول دارد.

هیستون دِاَستیلاز ۳ بر خلافِ سایر انواع هیستون داستیلازها یک نقش اختصاصی در تعدیل رونویسی ژنی توسط گیرنده‌های هسته‌ای دارد.

تعامل مولکولی

این پروتئین با مولکول‌های زیر تعامل پروتئین-پروتئین دارد:

منابع

[1]
GRCm38: Ensembl release 89: ENSMUSG00000024454 - Ensembl, May 2017
[2]
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
[3]
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
[4]
Emiliani S, Fischle W, Van Lint C, Al-Abed Y, Verdin E (April 1998). "Characterization of a human RPD3 ortholog, HDAC3". Proc Natl Acad Sci U S A. 95 (6): 2795–800. doi:10.1073/pnas.95.6.2795. PMC 19648. PMID 9501169.
[5]
Dangond F, Hafler DA, Tong JK, Randall J, Kojima R, Utku N, Gullans SR (March 1998). "Differential display cloning of a novel human histone deacetylase (HDAC3) cDNA from PHA-activated immune cells". Biochem Biophys Res Commun. 242 (3): 648–52. doi:10.1006/bbrc.1997.8033. PMID 9464271.
[6]
Montgomery, Rusty L.; Potthoff, Matthew J.; Haberland, Michael; Qi, Xiaoxia; Matsuzaki, Satoshi; Humphries, Kenneth M.; Richardson, James A.; Bassel-Duby, Rhonda; Olson, Eric N. (2008-11-03). "Maintenance of cardiac energy metabolism by histone deacetylase 3 in mice". Journal of Clinical Investigation (به انگلیسی). 118 (11): 3588–3597. doi:10.1172/jci35847. ISSN 0021-9738. PMC 2556240. PMID 18830415.
[7]
Bhaskara, Srividya; Chyla, Brenda J.; Amann, Joseph M.; Knutson, Sarah K.; Cortez, David; Sun, Zu-Wen; Hiebert, Scott W. (2008). "Deletion of Histone Deacetylase 3 Reveals Critical Roles in S Phase Progression and DNA Damage Control". Molecular Cell. 30 (1): 61–72. doi:10.1016/j.molcel.2008.02.030. PMC 2373760. PMID 18406327.
[8]
Petre-Draviam CE, Williams EB, Burd CJ, Gladden A, Moghadam H, Meller J, Diehl JA, Knudsen KE (January 2005). "A central domain of cyclin D1 mediates nuclear receptor corepressor activity". Oncogene. 24 (3): 431–44. doi:10.1038/sj.onc.1208200. PMID 15558026.
[9]
Lin HM, Zhao L, Cheng SY (August 2002). "Cyclin D1 Is a Ligand-independent Co-repressor for Thyroid Hormone Receptors". J. Biol. Chem. 277 (32): 28733–41. doi:10.1074/jbc.M203380200. PMID 12048199.
[10]
Fischle W, Dequiedt F, Fillion M, Hendzel MJ, Voelter W, Verdin E (September 2001). "Human HDAC7 histone deacetylase activity is associated with HDAC3 in vivo". J. Biol. Chem. 276 (38): 35826–35. doi:10.1074/jbc.M104935200. PMID 11466315.
[11]
Grozinger CM, Hassig CA, Schreiber SL (April 1999). "Three proteins define a class of human histone deacetylases related to yeast Hda1p". Proc. Natl. Acad. Sci. U.S.A. 96 (9): 4868–73. doi:10.1073/pnas.96.9.4868. PMC 21783. PMID 10220385.
[12]
Fischle W, Dequiedt F, Hendzel MJ, Guenther MG, Lazar MA, Voelter W, Verdin E (January 2002). "Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR". Mol. Cell. 9 (1): 45–57. doi:10.1016/S1097-2765(01)00429-4. PMID 11804585.
[13]
Grozinger CM, Schreiber SL (July 2000). "Regulation of histone deacetylase 4 and 5 and transcriptional activity by 14-3-3-dependent cellular localization". Proc. Natl. Acad. Sci. U.S.A. 97 (14): 7835–40. doi:10.1073/pnas.140199597. PMC 16631. PMID 10869435.
[14]
Zhang J, Kalkum M, Chait BT, Roeder RG (March 2002). "The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2". Mol. Cell. 9 (3): 611–23. doi:10.1016/S1097-2765(02)00468-9. PMID 11931768.
[15]
Petrie K, Guidez F, Howell L, Healy L, Waxman S, Greaves M, Zelent A (May 2003). "The histone deacetylase 9 gene encodes multiple protein isoforms". J. Biol. Chem. 278 (18): 16059–72. doi:10.1074/jbc.M212935200. PMID 12590135.
[16]
Zhou X, Richon VM, Rifkind RA, Marks PA (February 2000). "Identification of a transcriptional repressor related to the noncatalytic domain of histone deacetylases 4 and 5". Proc. Natl. Acad. Sci. U.S.A. 97 (3): 1056–61. doi:10.1073/pnas.97.3.1056. PMC 15519. PMID 10655483.
[17]
Wu WS, Vallian S, Seto E, Yang WM, Edmondson D, Roth S, Chang KS (April 2001). "The growth suppressor PML represses transcription by functionally and physically interacting with histone deacetylases". Mol. Cell. Biol. 21 (7): 2259–68. doi:10.1128/MCB.21.7.2259-2268.2001. PMC 86860. PMID 11259576.
[18]
Schroeder TM, Kahler RA, Li X, Westendorf JJ (October 2004). "Histone deacetylase 3 interacts with runx2 to repress the osteocalcin promoter and regulate osteoblast differentiation". J. Biol. Chem. 279 (40): 41998–2007. doi:10.1074/jbc.M403702200. PMID 15292260.
[19]
Yang WM, Yao YL, Sun JM, Davie JR, Seto E (October 1997). "Isolation and characterization of cDNAs corresponding to an additional member of the human histone deacetylase gene family". J. Biol. Chem. 272 (44): 28001–7. doi:10.1074/jbc.272.44.28001. PMID 9346952.
[20]
Yao YL, Yang WM, Seto E (September 2001). "Regulation of transcription factor YY1 by acetylation and deacetylation". Mol. Cell. Biol. 21 (17): 5979–91. doi:10.1128/MCB.21.17.5979-5991.2001. PMC 87316. PMID 11486036.

مشارکت‌کنندگان ویکی‌پدیا. «HDAC3». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۲۴ مارس ۲۰۲۰.

برای مطالعهٔ بیشتر

Verdin E, Dequiedt F, Kasler HG (2003). "Class II histone deacetylases: versatile regulators". Trends Genet. 19 (5): 286–93. doi:10.1016/S0168-9525(03)00073-8. PMID 12711221.

پیوند به بیرون

HDAC3 protein, human در سرعنوان‌های موضوعی پزشکی (MeSH) در کتابخانهٔ ملی پزشکی ایالات متحدهٔ آمریکا

این یک مقالهٔ خرد زیست‌شناسی مولکولی است. می‌توانید با گسترش آن به ویکی‌پدیا کمک کنید.

[refGRCm38Ensembl-1] [1]
GRCm38: Ensembl release 89: ENSMUSG00000024454 - Ensembl, May 2017

[2] [2]
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] [3]
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9501169-4] [4]
Emiliani S, Fischle W, Van Lint C, Al-Abed Y, Verdin E (April 1998). "Characterization of a human RPD3 ortholog, HDAC3". Proc Natl Acad Sci U S A. 95 (6): 2795–800. doi:10.1073/pnas.95.6.2795. PMC 19648. PMID 9501169.

[pmid9464271-5] [5]
Dangond F, Hafler DA, Tong JK, Randall J, Kojima R, Utku N, Gullans SR (March 1998). "Differential display cloning of a novel human histone deacetylase (HDAC3) cDNA from PHA-activated immune cells". Biochem Biophys Res Commun. 242 (3): 648–52. doi:10.1006/bbrc.1997.8033. PMID 9464271.

[6] [6]
Montgomery, Rusty L.; Potthoff, Matthew J.; Haberland, Michael; Qi, Xiaoxia; Matsuzaki, Satoshi; Humphries, Kenneth M.; Richardson, James A.; Bassel-Duby, Rhonda; Olson, Eric N. (2008-11-03). "Maintenance of cardiac energy metabolism by histone deacetylase 3 in mice". Journal of Clinical Investigation (به انگلیسی). 118 (11): 3588–3597. doi:10.1172/jci35847. ISSN 0021-9738. PMC 2556240. PMID 18830415.

[7] [7]
Bhaskara, Srividya; Chyla, Brenda J.; Amann, Joseph M.; Knutson, Sarah K.; Cortez, David; Sun, Zu-Wen; Hiebert, Scott W. (2008). "Deletion of Histone Deacetylase 3 Reveals Critical Roles in S Phase Progression and DNA Damage Control". Molecular Cell. 30 (1): 61–72. doi:10.1016/j.molcel.2008.02.030. PMC 2373760. PMID 18406327.

[pmid15558026-8] [8]
Petre-Draviam CE, Williams EB, Burd CJ, Gladden A, Moghadam H, Meller J, Diehl JA, Knudsen KE (January 2005). "A central domain of cyclin D1 mediates nuclear receptor corepressor activity". Oncogene. 24 (3): 431–44. doi:10.1038/sj.onc.1208200. PMID 15558026.

[pmid12048199-9] [9]
Lin HM, Zhao L, Cheng SY (August 2002). "Cyclin D1 Is a Ligand-independent Co-repressor for Thyroid Hormone Receptors". J. Biol. Chem. 277 (32): 28733–41. doi:10.1074/jbc.M203380200. PMID 12048199.

[pmid11466315-10] [10]
Fischle W, Dequiedt F, Fillion M, Hendzel MJ, Voelter W, Verdin E (September 2001). "Human HDAC7 histone deacetylase activity is associated with HDAC3 in vivo". J. Biol. Chem. 276 (38): 35826–35. doi:10.1074/jbc.M104935200. PMID 11466315.

[pmid10220385-11] [11]
Grozinger CM, Hassig CA, Schreiber SL (April 1999). "Three proteins define a class of human histone deacetylases related to yeast Hda1p". Proc. Natl. Acad. Sci. U.S.A. 96 (9): 4868–73. doi:10.1073/pnas.96.9.4868. PMC 21783. PMID 10220385.

[pmid11804585-12] [12]
Fischle W, Dequiedt F, Hendzel MJ, Guenther MG, Lazar MA, Voelter W, Verdin E (January 2002). "Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR". Mol. Cell. 9 (1): 45–57. doi:10.1016/S1097-2765(01)00429-4. PMID 11804585.

[pmid10869435-13] [13]
Grozinger CM, Schreiber SL (July 2000). "Regulation of histone deacetylase 4 and 5 and transcriptional activity by 14-3-3-dependent cellular localization". Proc. Natl. Acad. Sci. U.S.A. 97 (14): 7835–40. doi:10.1073/pnas.140199597. PMC 16631. PMID 10869435.

[pmid11931768-14] [14]
Zhang J, Kalkum M, Chait BT, Roeder RG (March 2002). "The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2". Mol. Cell. 9 (3): 611–23. doi:10.1016/S1097-2765(02)00468-9. PMID 11931768.

[pmid12590135-15] [15]
Petrie K, Guidez F, Howell L, Healy L, Waxman S, Greaves M, Zelent A (May 2003). "The histone deacetylase 9 gene encodes multiple protein isoforms". J. Biol. Chem. 278 (18): 16059–72. doi:10.1074/jbc.M212935200. PMID 12590135.

[pmid10655483-16] [16]
Zhou X, Richon VM, Rifkind RA, Marks PA (February 2000). "Identification of a transcriptional repressor related to the noncatalytic domain of histone deacetylases 4 and 5". Proc. Natl. Acad. Sci. U.S.A. 97 (3): 1056–61. doi:10.1073/pnas.97.3.1056. PMC 15519. PMID 10655483.

[pmid11259576-17] [17]
Wu WS, Vallian S, Seto E, Yang WM, Edmondson D, Roth S, Chang KS (April 2001). "The growth suppressor PML represses transcription by functionally and physically interacting with histone deacetylases". Mol. Cell. Biol. 21 (7): 2259–68. doi:10.1128/MCB.21.7.2259-2268.2001. PMC 86860. PMID 11259576.

[pmid15292260-18] [18]
Schroeder TM, Kahler RA, Li X, Westendorf JJ (October 2004). "Histone deacetylase 3 interacts with runx2 to repress the osteocalcin promoter and regulate osteoblast differentiation". J. Biol. Chem. 279 (40): 41998–2007. doi:10.1074/jbc.M403702200. PMID 15292260.

[pmid9346952-19] [19]
Yang WM, Yao YL, Sun JM, Davie JR, Seto E (October 1997). "Isolation and characterization of cDNAs corresponding to an additional member of the human histone deacetylase gene family". J. Biol. Chem. 272 (44): 28001–7. doi:10.1074/jbc.272.44.28001. PMID 9346952.

[pmid11486036-20] [20]
Yao YL, Yang WM, Seto E (September 2001). "Regulation of transcription factor YY1 by acetylation and deacetylation". Mol. Cell. Biol. 21 (17): 5979–91. doi:10.1128/MCB.21.17.5979-5991.2001. PMC 87316. PMID 11486036.

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