پروتئین شمارهٔ ۲ متصل به گیرندهٔ فاکتور رشد (انگلیسی: Growth factor receptor-bound protein 2) که بهاختصار «Grb2» نامیده میشود، یک پروتئین وفقدهنده ترارسانی پیام است که در فرایند ترارسانی پیام/ارتباطات سلولی دخالت دارد. در انسان، این پروتئین توسط ژن «GRB2» کدگذاری میشود.[4][5]
پروتئینی که توسط ژن «GRB2» ساخته میشود به گیرندههایی چون گیرنده فاکتور رشد اپیدرمی اتصال مییابد.
اطلاعات اجمالی ساختارهای موجود, PDB ...
GRB2 |
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ساختارهای موجود |
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PDB | جستجوی همساختشناسی: PDBe RCSB |
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فهرست شناسههای PDB |
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1AZE, 1BM2, 1BMB, 1CJ1, 1FHS, 1FYR, 1GCQ, 1GFC, 1GFD, 1GHU, 1GRI, 1IO6, 1JYQ, 1JYR, 1JYU, 1QG1, 1TZE, 1X0N, 1ZFP, 2AOA, 2AOB, 2H5K, 2HUW, 2VVK, 2VWF, 2W0Z, 3C7I, 3IMD, 3IMJ, 3IN7, 3IN8, 3KFJ, 3MXC, 3MXY, 3N7Y, 3N84, 3N8M, 3OV1, 3OVE, 3S8L, 3S8N, 3S8O, 2H46, 3WA4, 4P9V, 4P9Z, 5CDW |
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معینکنندهها |
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نامهای دیگر | GRB2, ASH, EGFRBP-Grb3-3, MST084, MSTP084, NCKAP2, growth factor receptor bound protein 2 |
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شناسههای بیرونی | OMIM: 108355 MGI: 95805 HomoloGene: 1576 GeneCards: GRB2 |
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همساختشناسی |
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گونهها | انسان | موش |
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Entrez | | |
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آنسامبل | | |
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یونیپروت | | |
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RefSeq (mRNA) | | |
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RefSeq (پروتئین) | | |
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موقعیت (UCSC) | ن/م | Chr : 115.53 – 115.6 Mb |
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جستجوی PubMed | [2] | [3] |
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ویکیداده |
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بستن
تخریب این ژن در موشهای آزمایشگاهی باعث شد تا رویان آنها در مراحل اولیهٔ تشکیل از بین بروند.
مشخص شده است که Grb2 با پروتئین های زیر تعامل پروتئین-پروتئین دارد:
VanderNoot VA, Fitzpatrick FA (Sep 1995). "Competitive binding assay of src homology domain 3 interactions between 5-lipoxygenase and growth factor receptor binding protein 2". Analytical Biochemistry. 230 (1): 108–14. doi:10.1006/abio.1995.1444. PMID 8585605.
Erdreich-Epstein A, Liu M, Kant AM, Izadi KD, Nolta JA, Durden DL (Apr 1999). "Cbl functions downstream of Src kinases in Fc gamma RI signaling in primary human macrophages". Journal of Leukocyte Biology. 65 (4): 523–34. doi:10.1002/jlb.65.4.523. PMID 10204582. S2CID 18340540.
Park RK, Erdreich-Epstein A, Liu M, Izadi KD, Durden DL (Dec 1999). "High affinity IgG receptor activation of Src family kinases is required for modulation of the Shc-Grb2-Sos complex and the downstream activation of the nicotinamide adenine dinucleotide phosphate (reduced) oxidase". Journal of Immunology. 163 (11): 6023–34. PMID 10570290.
Robertson H, Langdon WY, Thien CB, Bowtell DD (Nov 1997). "A c-Cbl yeast two hybrid screen reveals interactions with 14-3-3 isoforms and cytoskeletal components". Biochemical and Biophysical Research Communications. 240 (1): 46–50. doi:10.1006/bbrc.1997.7608. PMID 9367879.
Odai H, Sasaki K, Iwamatsu A, Nakamoto T, Ueno H, Yamagata T, Mitani K, Yazaki Y, Hirai H (Apr 1997). "Purification and molecular cloning of SH2- and SH3-containing inositol polyphosphate-5-phosphatase, which is involved in the signaling pathway of granulocyte-macrophage colony-stimulating factor, erythropoietin, and Bcr-Abl". Blood. 89 (8): 2745–56. doi:10.1182/blood.V89.8.2745. PMID 9108392.
Hsia DA, Mitra SK, Hauck CR, Streblow DN, Nelson JA, Ilic D, Huang S, Li E, Nemerow GR, Leng J, Spencer KS, Cheresh DA, Schlaepfer DD (Mar 2003). "Differential regulation of cell motility and invasion by FAK". The Journal of Cell Biology. 160 (5): 753–67. doi:10.1083/jcb.200212114. PMC 2173366. PMID 12615911.
Ong SH, Goh KC, Lim YP, Low BC, Klint P, Claesson-Welsh L, Cao X, Tan YH, Guy GR (Aug 1996). "Suc1-associated neurotrophic factor target (SNT) protein is a major FGF-stimulated tyrosine phosphorylated 90-kDa protein which binds to the SH2 domain of GRB2". Biochemical and Biophysical Research Communications. 225 (3): 1021–6. doi:10.1006/bbrc.1996.1288. PMID 8780727.
Ghadimi MP, Sanzenbacher R, Thiede B, Wenzel J, Jing Q, Plomann M, Borkhardt A, Kabelitz D, Janssen O (May 2002). "Identification of interaction partners of the cytosolic polyproline region of CD95 ligand (CD178)". FEBS Letters. 519 (1–3): 50–8. doi:10.1016/s0014-5793(02)02709-6. PMID 12023017. S2CID 26765451.
Lee IS, Liu Y, Narazaki M, Hibi M, Kishimoto T, Taga T (Jan 1997). "Vav is associated with signal transducing molecules gp130, Grb2 and Erk2, and is tyrosine phosphorylated in response to interleukin-6". FEBS Letters. 401 (2–3): 133–7. doi:10.1016/s0014-5793(96)01456-1. PMID 9013873. S2CID 32632406.
Giorgetti-Peraldi S, Peyrade F, Baron V, Van Obberghen E (Dec 1995). "Involvement of Janus kinases in the insulin signaling pathway". European Journal of Biochemistry. 234 (2): 656–60. doi:10.1111/j.1432-1033.1995.656_b.x. PMID 8536716.
Kim H, Lee YH, Won J, Yun Y (Sep 2001). "Through induction of juxtaposition and tyrosine kinase activity of Jak1, X-gene product of hepatitis B virus stimulates Ras and the transcriptional activation through AP-1, NF-kappaB, and SRE enhancers". Biochemical and Biophysical Research Communications. 286 (5): 886–94. doi:10.1006/bbrc.2001.5496. PMID 11527382.
Perez-Villar JJ, Whitney GS, Sitnick MT, Dunn RJ, Venkatesan S, O'Day K, Schieven GL, Lin TA, Kanner SB (Aug 2002). "Phosphorylation of the linker for activation of T-cells by Itk promotes recruitment of Vav". Biochemistry. 41 (34): 10732–40. doi:10.1021/bi025554o. PMID 12186560.
Asada H, Ishii N, Sasaki Y, Endo K, Kasai H, Tanaka N, Takeshita T, Tsuchiya S, Konno T, Sugamura K (May 1999). "Grf40, A novel Grb2 family member, is involved in T cell signaling through interaction with SLP-76 and LAT". The Journal of Experimental Medicine. 189 (9): 1383–90. doi:10.1084/jem.189.9.1383. PMC 2193052. PMID 10224278.
Pandey P, Kharbanda S, Kufe D (Sep 1995). "Association of the DF3/MUC1 breast cancer antigen with Grb2 and the Sos/Ras exchange protein". Cancer Research. 55 (18): 4000–3. PMID 7664271.
Saleem A, Datta R, Yuan ZM, Kharbanda S, Kufe D (Dec 1995). "Involvement of stress-activated protein kinase in the cellular response to 1-beta-D-arabinofuranosylcytosine and other DNA-damaging agents". Cell Growth & Differentiation. 6 (12): 1651–8. PMID 9019171.
Pei Z, Maloney JA, Yang L, Williamson JR (Sep 1997). "A new function for phospholipase C-gamma1: coupling to the adaptor protein GRB2". Archives of Biochemistry and Biophysics. 345 (1): 103–10. doi:10.1006/abbi.1997.0245. PMID 9281317.
Tanaka S, Morishita T, Hashimoto Y, Hattori S, Nakamura S, Shibuya M, Matuoka K, Takenawa T, Kurata T, Nagashima K (Apr 1994). "C3G, a guanine nucleotide-releasing protein expressed ubiquitously, binds to the Src homology 3 domains of CRK and GRB2/ASH proteins". Proceedings of the National Academy of Sciences of the United States of America. 91 (8): 3443–7. Bibcode:1994PNAS...91.3443T. doi:10.1073/pnas.91.8.3443. PMC 43593. PMID 7512734.
Gout I, Middleton G, Adu J, Ninkina NN, Drobot LB, Filonenko V, Matsuka G, Davies AM, Waterfield M, Buchman VL (Aug 2000). "Negative regulation of PI 3-kinase by Ruk, a novel adaptor protein". The EMBO Journal. 19 (15): 4015–25. doi:10.1093/emboj/19.15.4015. PMC 306608. PMID 10921882.
Borinstein SC, Hyatt MA, Sykes VW, Straub RE, Lipkowitz S, Boulter J, Bogler O (Dec 2000). "SETA is a multifunctional adapter protein with three SH3 domains that binds Grb2, Cbl, and the novel SB1 proteins". Cellular Signalling. 12 (11–12): 769–79. doi:10.1016/s0898-6568(00)00129-7. PMID 11152963.
Satoh T, Kato J, Nishida K, Kaziro Y (May 1996). "Tyrosine phosphorylation of ACK in response to temperature shift-down, hyperosmotic shock, and epidermal growth factor stimulation". FEBS Letters. 386 (2–3): 230–4. doi:10.1016/0014-5793(96)00449-8. PMID 8647288. S2CID 23523548.
Park RK, Izadi KD, Deo YM, Durden DL (Sep 1999). "Role of Src in the modulation of multiple adaptor proteins in FcalphaRI oxidant signaling". Blood. 94 (6): 2112–20. doi:10.1182/blood.V94.6.2112. PMID 10477741.
Sakaguchi K, Okabayashi Y, Kasuga M (Apr 2001). "Shc mediates ligand-induced internalization of epidermal growth factor receptors". Biochemical and Biophysical Research Communications. 282 (5): 1154–60. doi:10.1006/bbrc.2001.4680. PMID 11302736.
Hallak H, Seiler AE, Green JS, Henderson A, Ross BN, Rubin R (Jul 2001). "Inhibition of insulin-like growth factor-I signaling by ethanol in neuronal cells". Alcoholism: Clinical and Experimental Research. 25 (7): 1058–64. doi:10.1111/j.1530-0277.2001.tb02317.x. PMID 11505033.
Giordano V, De Falco G, Chiari R, Quinto I, Pelicci PG, Bartholomew L, Delmastro P, Gadina M, Scala G (May 1997). "Shc mediates IL-6 signaling by interacting with gp130 and Jak2 kinase". Journal of Immunology. 158 (9): 4097–103. PMID 9126968.
Tong XK, Hussain NK, de Heuvel E, Kurakin A, Abi-Jaoude E, Quinn CC, Olson MF, Marais R, Baranes D, Kay BK, McPherson PS (Mar 2000). "The endocytic protein intersectin is a major binding partner for the Ras exchange factor mSos1 in rat brain". The EMBO Journal. 19 (6): 1263–71. doi:10.1093/emboj/19.6.1263. PMC 305667. PMID 10716926.
Chin H, Saito T, Arai A, Yamamoto K, Kamiyama R, Miyasaka N, Miura O (Oct 1997). "Erythropoietin and IL-3 induce tyrosine phosphorylation of CrkL and its association with Shc, SHP-2, and Cbl in hematopoietic cells". Biochemical and Biophysical Research Communications. 239 (2): 412–7. doi:10.1006/bbrc.1997.7480. PMID 9344843.
Kato-Stankiewicz J, Ueda S, Kataoka T, Kaziro Y, Satoh T (Jun 2001). "Epidermal growth factor stimulation of the ACK1/Dbl pathway in a Cdc42 and Grb2-dependent manner". Biochemical and Biophysical Research Communications. 284 (2): 470–7. doi:10.1006/bbrc.2001.5004. PMID 11394904.
Zeng L, Sachdev P, Yan L, Chan JL, Trenkle T, McClelland M, Welsh J, Wang LH (Dec 2000). "Vav3 mediates receptor protein tyrosine kinase signaling, regulates GTPase activity, modulates cell morphology, and induces cell transformation". Molecular and Cellular Biology. 20 (24): 9212–24. doi:10.1128/mcb.20.24.9212-9224.2000. PMC 102179. PMID 11094073.
- Colledge M, Froehner SC (May 1998). "Interaction between the nicotinic acetylcholine receptor and Grb2. Implications for signaling at the neuromuscular junction". Annals of the New York Academy of Sciences. 841: 17–27. doi:10.1111/j.1749-6632.1998.tb10907.x. PMID 9668219.
- Ramesh N, Antón IM, Martínez-Quiles N, Geha RS (Jan 1999). "Waltzing with WASP". Trends in Cell Biology. 9 (1): 15–9. doi:10.1016/S0962-8924(98)01411-1. PMID 10087612.
- O'Sullivan E, Kinnon C, Brickell P (1999). "Wiskott-Aldrich syndrome protein, WASP". The International Journal of Biochemistry & Cell Biology. 31 (3–4): 383–7. doi:10.1016/S1357-2725(98)00118-6. PMID 10224664.
- Schlaepfer DD, Hauck CR, Sieg DJ (1999). "Signaling through focal adhesion kinase". Progress in Biophysics and Molecular Biology. 71 (3–4): 435–78. doi:10.1016/S0079-6107(98)00052-2. PMID 10354709.
- Vidal M, Liu WQ, Gril B, Assayag F, Poupon MF, Garbay C (2004). "[Design of new anti-tumor agents interrupting deregulated signaling pathways induced by tyrosine kinase proteins. Inhibition of protein-protein interaction involving Grb2]". Journal De La Société De Biologie. 198 (2): 133–7. PMID 15368963.