GNA13

پروتئین متصل‌شونده به نوکلئوتید گوانین، زیرواحد آلفا-۱۳ (انگلیسی: Guanine nucleotide-binding protein subunit alpha-13) یک پروتئین است که در انسان توسط ژن «GNA13» کُدگذاری می‌شود.^[4][5]

GNA13
ساختارهای موجود PDB جستجوی هم‌ساخت‌شناسی: PDBe RCSB فهرست شناسه‌های PDB 1SHZ, 1ZCB, 3AB3, 3CX6, 3CX7, 3CX8
معین‌کننده‌ها
نام‌های دیگر	GNA13, G13, G protein subunit alpha 13, HG1N
شناسه‌های بیرونی	OMIM: 604406 MGI: 95768 HomoloGene: 55976 GeneCards: GNA13
موقعیت ژن (موش) کروموزوم کروموزوم ۱۱ (موش)[1] نوار 11 E1|11 71.88 cM شروع 109,253,657 bp[1] پایان 109,292,195 bp[1]
الگوی گسترش RNA More reference expression data
هستی‌شناسی ژن عملکرد ملکولی • nucleotide binding • G-protein beta/gamma-subunit complex binding • type 1 angiotensin receptor binding • GTP binding • D5 dopamine receptor binding • signal transducer activity • metal ion binding • GO:0001948، GO:0016582 پیوند پروتئینی • guanyl nucleotide binding • G protein-coupled receptor binding • guanyl-nucleotide exchange factor activity • GO:0006184 GTPase activity ترکیبات سلولی • membrane • focal adhesion • melanosome • brush border membrane • heterotrimeric G-protein complex • extracellular exosome • هسته یاخته • سیتوپلاسم • سیتوزول • پوسته یاخته فرایند زیستی • دگرگونی یاخته‌ • GO:0007243 intracellular signal transduction • regulation of cell migration • adenylate cyclase-activating G protein-coupled receptor signaling pathway • positive regulation of cytosolic calcium ion concentration • small GTPase mediated signal transduction • in utero embryonic development • platelet activation • activation of phospholipase D activity • Rho protein signal transduction • رگ‌زایی • regulation of cell shape • branching involved in blood vessel morphogenesis • GO:0072468 ورارسانی پیام • positive regulation of apoptotic process • regulation of small GTPase mediated signal transduction • G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
گونه‌ها	انسان	موش
Entrez	10672	14674
آنسامبل	ENSG00000120063	ENSMUSG00000020611
یونی‌پروت	Q14344	P27601
RefSeq (mRNA)	NM_006572 NM_001282425، NM_006572	NM_001359034 NM_010303، NM_001359034
RefSeq (پروتئین)	NP_006563، XP_011522504 NP_001269354، NP_006563، XP_011522504	NP_001345963 NP_034433، NP_001345963
موقعیت (UCSC)	ن/م	Chr : 109.25 – 109.29 Mb
جستجوی PubMed	[2]	[3]
ویکی‌داده
مشاهده/ویرایش انسان مشاهده/ویرایش موش

این پروتئین با رادیکسین تعامل پروتئین-پروتئین دارد.^[6]

اهمیت بالینی

جهش‌های مکرر در این ژن را با بروز لنفوم بزرگ سلول بی منتشر مرتبط دانسته‌اند.^[7][8]

جستارهای وابسته

• گیرنده جفت‌شونده با پروتئین جی

منابع

1. GRCm38: Ensembl release 89: ENSMUSG00000020611 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Kabouridis PS, Waters ST, Escobar S, Stanners J, Tsoukas CD (Mar 1995). "Expression of GTP-binding protein alpha subunits in human thymocytes". Molecular and Cellular Biochemistry. 144 (1): 45–51. doi:10.1007/BF00926739. PMID 7791744. S2CID 8911988.
5. "Entrez Gene: GNA13 guanine nucleotide binding protein (G protein), alpha 13".
6. Vaiskunaite R, Adarichev V, Furthmayr H, Kozasa T, Gudkov A, Voyno-Yasenetskaya TA (Aug 2000). "Conformational activation of radixin by G13 protein alpha subunit". The Journal of Biological Chemistry. 275 (34): 26206–12. doi:10.1074/jbc.M001863200. PMID 10816569.
7. Morin RD, Mendez-Lago M, Mungall AJ, Goya R, Mungall KL, Corbett RD, Johnson NA, Severson TM, Chiu R, Field M, Jackman S, Krzywinski M, Scott DW, Trinh DL, Tamura-Wells J, Li S, Firme MR, Rogic S, Griffith M, Chan S, Yakovenko O, Meyer IM, Zhao EY, Smailus D, Moksa M, Chittaranjan S, Rimsza L, Brooks-Wilson A, Spinelli JJ, Ben-Neriah S, Meissner B, Woolcock B, Boyle M, McDonald H, Tam A, Zhao Y, Delaney A, Zeng T, Tse K, Butterfield Y, Birol I, Holt R, Schein J, Horsman DE, Moore R, Jones SJ, Connors JM, Hirst M, Gascoyne RD, Marra MA (Aug 2011). "Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma". Nature. 476 (7360): 298–303. Bibcode:2011Natur.476..298M. doi:10.1038/nature10351. PMC 3210554. PMID 21796119.
8. Lohr JG, Stojanov P, Lawrence MS, Auclair D, Chapuy B, Sougnez C, Cruz-Gordillo P, Knoechel B, Asmann YW, Slager SL, Novak AJ, Dogan A, Ansell SM, Link BK, Zou L, Gould J, Saksena G, Stransky N, Rangel-Escareño C, Fernandez-Lopez JC, Hidalgo-Miranda A, Melendez-Zajgla J, Hernández-Lemus E, Schwarz-Cruz y Celis A, Imaz-Rosshandler I, Ojesina AI, Jung J, Pedamallu CS, Lander ES, Habermann TM, Cerhan JR, Shipp MA, Getz G, Golub TR (Mar 2012). "Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing". Proceedings of the National Academy of Sciences of the United States of America. 109 (10): 3879–84. Bibcode:2012PNAS..109.3879L. doi:10.1073/pnas.1121343109. PMC 3309757. PMID 22343534.

• مشارکت‌کنندگان ویکی‌پدیا. «GNA13». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۲۳ اکتبر ۲۰۲۱.

برای مطالعهٔ بیشتر

• Ruppel KM, Willison D, Kataoka H, Wang A, Zheng YW, Cornelissen I, Yin L, Xu SM, Coughlin SR (Jun 2005). "Essential role for Galpha13 in endothelial cells during embryonic development". Proceedings of the National Academy of Sciences of the United States of America. 102 (23): 8281–8286. Bibcode:2005PNAS..102.8281R. doi:10.1073/pnas.0503326102. PMC 1149452. PMID 15919816.
• Downes GB, Gautam N (Dec 1999). "The G protein subunit gene families". Genomics. 62 (3): 544–52. doi:10.1006/geno.1999.5992. PMID 10644457.
• Offermanns S, Laugwitz KL, Spicher K, Schultz G (Jan 1994). "G proteins of the G12 family are activated via thromboxane A2 and thrombin receptors in human platelets". Proceedings of the National Academy of Sciences of the United States of America. 91 (2): 504–8. Bibcode:1994PNAS...91..504O. doi:10.1073/pnas.91.2.504. PMC 42977. PMID 8290554.
• Laugwitz KL, Allgeier A, Offermanns S, Spicher K, Van Sande J, Dumont JE, Schultz G (Jan 1996). "The human thyrotropin receptor: a heptahelical receptor capable of stimulating members of all four G protein families". Proceedings of the National Academy of Sciences of the United States of America. 93 (1): 116–20. Bibcode:1996PNAS...93..116L. doi:10.1073/pnas.93.1.116. PMC 40189. PMID 8552586.
• Offermanns S, Hu YH, Simon MI (Oct 1996). "Galpha12 and galpha13 are phosphorylated during platelet activation". The Journal of Biological Chemistry. 271 (42): 26044–8. doi:10.1074/jbc.271.42.26044. PMID 8824244.
• Offermanns S, Mancino V, Revel JP, Simon MI (Jan 1997). "Vascular system defects and impaired cell chemokinesis as a result of Galpha13 deficiency". Science. 275 (5299): 533–6. doi:10.1126/science.275.5299.533. PMID 8999798. S2CID 32210248.
• Macrez-Leprêtre N, Kalkbrenner F, Morel JL, Schultz G, Mironneau J (Apr 1997). "G protein heterotrimer Galpha13beta1gamma3 couples the angiotensin AT1A receptor to increases in cytoplasmic Ca2+ in rat portal vein myocytes". The Journal of Biological Chemistry. 272 (15): 10095–102. doi:10.1074/jbc.272.15.10095. PMID 9092554.
• Hart MJ, Jiang X, Kozasa T, Roscoe W, Singer WD, Gilman AG, Sternweis PC, Bollag G (Jun 1998). "Direct stimulation of the guanine nucleotide exchange activity of p115 RhoGEF by Galpha13". Science. 280 (5372): 2112–4. doi:10.1126/science.280.5372.2112. PMID 9641916.
• Becker KP, Garnovskaya M, Gettys T, Halushka PV (Jul 1999). "Coupling of thromboxane A2 receptor isoforms to Galpha13: effects on ligand binding and signalling". Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1450 (3): 288–96. doi:10.1016/S0167-4889(99)00068-3. PMID 10395940.
• Windh RT, Lee MJ, Hla T, An S, Barr AJ, Manning DR (Sep 1999). "Differential coupling of the sphingosine 1-phosphate receptors Edg-1, Edg-3, and H218/Edg-5 to the G(i), G(q), and G(12) families of heterotrimeric G proteins". The Journal of Biological Chemistry. 274 (39): 27351–8. doi:10.1074/jbc.274.39.27351. PMID 10488065.
• Brydon L, Roka F, Petit L, de Coppet P, Tissot M, Barrett P, Morgan PJ, Nanoff C, Strosberg AD, Jockers R (Dec 1999). "Dual signaling of human Mel1a melatonin receptors via G(i2), G(i3), and G(q/11) proteins". Molecular Endocrinology (Baltimore, Md.). 13 (12): 2025–38. doi:10.1210/me.13.12.2025. PMID 10598579.
• Bhattacharyya R, Wedegaertner PB (May 2000). "Galpha 13 requires palmitoylation for plasma membrane localization, Rho-dependent signaling, and promotion of p115-RhoGEF membrane binding". The Journal of Biological Chemistry. 275 (20): 14992–9. doi:10.1074/jbc.M000415200. PMID 10747909.
• Vaiskunaite R, Adarichev V, Furthmayr H, Kozasa T, Gudkov A, Voyno-Yasenetskaya TA (Aug 2000). "Conformational activation of radixin by G13 protein alpha subunit". The Journal of Biological Chemistry. 275 (34): 26206–12. doi:10.1074/jbc.M001863200. PMID 10816569.
• Shi CS, Sinnarajah S, Cho H, Kozasa T, Kehrl JH (Aug 2000). "G13alpha-mediated PYK2 activation. PYK2 is a mediator of G13alpha -induced serum response element-dependent transcription". The Journal of Biological Chemistry. 275 (32): 24470–6. doi:10.1074/jbc.M908449199. PMID 10821841.
• Ponimaskin E, Behn H, Adarichev V, Voyno-Yasenetskaya TA, Offermanns S, Schmidt MF (Jul 2000). "Acylation of Galpha(13) is important for its interaction with thrombin receptor, transforming activity and actin stress fiber formation". FEBS Letters. 478 (1–2): 173–7. doi:10.1016/S0014-5793(00)01845-7. PMID 10922491. S2CID 31417083.
• Jin S, Exton JH (Nov 2000). "Activation of RhoA by association of Galpha(13) with Dbl". Biochemical and Biophysical Research Communications. 277 (3): 718–21. doi:10.1006/bbrc.2000.3744. PMID 11062019.
• Fukuhara S, Chikumi H, Gutkind JS (Nov 2000). "Leukemia-associated Rho guanine nucleotide exchange factor (LARG) links heterotrimeric G proteins of the G(12) family to Rho". FEBS Letters. 485 (2–3): 183–8. doi:10.1016/S0014-5793(00)02224-9. PMID 11094164. S2CID 7300556.
• Meigs TE, Fields TA, McKee DD, Casey PJ (Jan 2001). "Interaction of Galpha 12 and Galpha 13 with the cytoplasmic domain of cadherin provides a mechanism for beta -catenin release". Proceedings of the National Academy of Sciences of the United States of America. 98 (2): 519–24. doi:10.1073/pnas.021350998. PMC 14619. PMID 11136230.

پیوند به بیرون

• خلاصه‌ای از اطلاعات ساختاری موجود در بانک داده پروتئین برای یونی‌پروت: P27601 (Mouse Guanine nucleotide-binding protein subunit alpha-13) در PDBe-KB.