Errenina

Errenina^[6] aparatu justaglomerularra osatzen duten glomeruluko arteriola aferenteko zeluletan sintetizatzen den entzima da. II angiotentsinaren sorrera dakarten erreakzio kimikoen segida abiarazten du.^[7] Robert Tigerstedtek 1898an aurkitu eta deskribatu zuen.

REN
Egitura erabilgarria PDB Ortologoaren bilaketa: PDBe RCSB PDB ID kodeen zerrenda 4XX4, 1BBS, 1BIL, 1BIM, 1HRN, 1RNE, 2BKS, 2BKT, 2FS4, 2G1N, 2G1O, 2G1R, 2G1S, 2G1Y, 2G20, 2G21, 2G22, 2G24, 2G26, 2G27, 2I4Q, 2IKO, 2IKU, 2IL2, 2REN, 2V0Z, 2V10, 2V11, 2V12, 2V13, 2V16, 2X0B, 3D91, 3G6Z, 3G70, 3G72, 3GW5, 3K1W, 3KM4, 3O9L, 3OAD, 3OAG, 3OOT, 3OQF, 3OQK, 3OWN, 3Q3T, 3Q4B, 3Q5H, 3SFC, 3VCM, 3VSW, 3VSX, 3VUC, 3VYD, 3VYE, 3VYF, 4AMT, 4GJ5, 4GJ6, 4GJ7, 4GJ8, 4GJ9, 4GJA, 4GJB, 4GJC, 4GJD, 4PYV, 4Q1N, 4RYC, 4RYG, 4RZ1, 4S1G, 4XX3
Identifikatzaileak
Aliasak	REN (HUGO), HNFJ2, renin, ADTKD4, RTD
Kanpoko IDak	OMIM: 179820   MGI: 97898   HomoloGene: 20151   GeneCards: REN   OMA: REN - orthologs
Genetikoki lotutako gaixotasunak
renal tubular dysgenesis of genetic origin , hyperuricemia-anemia-renal failure syndrome  [1]
Drogaren xedea
aliskiren  [2]
Genearen kokapena (gizakia) Kromosoma: 1 (gizakia)[3] Banda 1q32.1 Hasiera 204.154.819 bp[3] Amaiera 204.190.324 bp[3]
RNA adierazpen eredua Bgee gizakia sagua (ortholog) Adierazpen ohikoena Dezidua human kidney  stromal cell of endometrium  left ovary  Barrabil right ovary  giltzurrun-azal metanephros  metanephric glomerulus  body of uterus  Erreferentziazko adierazpen datu gehiago BioGPS
Gene ontologia Funtzio molekularra insulin-like growth factor receptor binding  aspartic-type endopeptidase activity  endopeptidase activity  peptidase activity  signaling receptor binding  hydrolase activity  proteina lotura  Zelularen osagaia zitoplasma  mintza  zelula mintz  intrazelular  zelulaz kanpoko eremu  extracellular space  apical part of cell  Prozesu biologikoa response to immobilization stress  regulation of blood volume by renin-angiotensin  male gonad development  regulation of MAPK cascade  kidney development  renin-angiotensin regulation of aldosterone production  cell maturation  amyloid-beta metabolic process  response to organic substance  angiotensin maturation  proteolisi  mesonephros development  regulation of blood pressure  response to lipopolysaccharide  Proteinen katabolismo  drinking behavior  hormone-mediated signaling pathway  response to cGMP  response to cAMP  Iturburuak: : Amigo / QuickGO
Ortologoak Espeziea Gizakia Sagua Entrez 5972 19701 Ensembl ENSG00000143839 ENSMUSG00000070645 UniProt P00797 P06281 RefSeq (RNAm) NM_000537 NM_031192 RefSeq (proteina) NP_000528 NP_112469 Kokapena (UCSC) Chr 1: 204.15 – 204.19 Mb PubMed bilaketa [4] [5]
Wikidata
Ikusi/Editatu giza genea Ikusi/Editatu saguaren genea