Leptinaren errezeptore

Leptinaren errezeptorea, LEP-R edo OB-r I motako zitokina errezeptore bat da^[7], gizakiengan LEPR geneak kodetzen duen proteina bat^[8][9]. LEP-Rk leptina hormonaren zelulako gantza errezeptorearen funtzioa du. LEP-R ere CD295 gisa identifikatu da (295. diferentziazio klusterra). Zelula-mintzan kokatuta dago, eta zelulatik kanpoko, mintza zeharkatzeko eta zelula barneko proteina eskualdeak ditu.

Leptinaren errezeptore
Egitura erabilgarria PDB Ortologoaren bilaketa: PDBe RCSB PDB ID kodeen zerrenda 3V6O
Identifikatzaileak
Aliasak	LEPR (HUGO), CD295, LEP-R, LEPRD, OB-R, OBR, leptin receptor
Kanpoko IDak	OMIM: 601007   MGI: 104993   HomoloGene: 1731   GeneCards: LEPR   OMA: LEPR - orthologs
Genetikoki lotutako gaixotasunak
morbid obesity , obesity due to leptin receptor gene deficiency  [1]
Drogaren xedea
metreleptin  [2]
Genearen kokapena (gizakia) Kromosoma: 1 (gizakia)[3] Banda 1p31.3 Hasiera 65.420.652 bp[3] Amaiera 65.641.559 bp[3]
Genearen kokapena (sagua) Kromosoma: 4 (sagua)[4] Banda 4 C6|4 46.96 cM Hasiera 101.574.601 bp[4] Amaiera 101.672.549 bp[4]
RNA adierazpen eredua Bgee gizakia sagua (ortholog) Adierazpen ohikoena trabecular bone  Epithelium of choroid plexus  trigeminal ganglion  Perikardio skin of hip  oral cavity  mucosa of pharynx  lower lobe of lung  skin of thigh  Uretra Adierazpen ohikoena lumbar spinal ganglion  Epithelium of choroid plexus  dermis eskumako birika  mesenteric lymph nodes  Balbula aortiko membranous bone  Dermatocranium  right lung lobe  Paneth cell  Erreferentziazko adierazpen datu gehiago BioGPS
Gene ontologia Funtzio molekularra leptin receptor activity  proteina lotura  identical protein binding  cytokine receptor activity  transmembrane signaling receptor activity  peptide hormone binding  cytokine binding  Zelularen osagaia zelula-mintzaren osagai integrala  mintza  receptor complex  zelula mintz  zelulaz kanpoko eremu  basolateral plasma membrane  external side of plasma membrane  Prozesu biologikoa ugalketa sexual  glucose homeostasis  leptin-mediated signaling pathway  cholesterol metabolic process  negative regulation of hydrolase activity  regulation of feeding behavior  izaki zelulanitzen garapena  negative regulation of gluconeogenesis  cell surface receptor signaling pathway  T cell differentiation  angiogenesis  energy homeostasis  bone growth  energy reserve metabolic process  response to leptin  negative regulation of autophagy  regulation of bone remodeling  Fagozitosi  positive regulation of cold-induced thermogenesis  glycogen metabolic process  glial cell proliferation  Iturburuak: : Amigo / QuickGO
Ortologoak Espeziea Gizakia Sagua Entrez 3953 16847 Ensembl ENSG00000116678 ENSMUSG00000057722 UniProt P48357 P48356 RefSeq (RNAm) NM_002303 NM_001003679 NM_001003680 NM_001198687 NM_001198688 NM_001198689 NM_001122899 NM_010704 NM_146146 RefSeq (proteina) NP_001003679 NP_001003680 NP_001185616 NP_001185617 NP_001185618 NP_002294 NP_001116371 NP_034834 NP_666258 Kokapena (UCSC) Chr 1: 65.42 – 65.64 Mb Chr 4: 101.57 – 101.67 Mb PubMed bilaketa [5] [6]
Wikidata
Ikusi/Editatu giza genea Ikusi/Editatu saguaren genea

Erreferentziak

1. Genetikoki lotutako gaixotasunak Leptinaren errezeptoreikusi/editatu erreferentziak Wikidatan. .
2. Fisikoki elkarreragiten duten drogak leptin receptorikusi/editatu erreferentziak Wikidatan. .
3. GRCh38: Ensembl release 89: ENSG00000116678 - Ensembl, May 2017
4. GRCm38: Ensembl release 89: ENSMUSG00000057722 – Ensembl, May 2017
5. Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
6. Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
7. (Ingelesez) Cirillo, Donatella; Rachiglio, Anna Maria; Montagna, Raffaele la; Giordano, Antonio; Normanno, Nicola. (2008). «Leptin signaling in breast cancer: An overview» Journal of Cellular Biochemistry 105 (4): 956–964.  doi:10.1002/jcb.21911. ISSN 1097-4644. (Noiz kontsultatua: 2021-06-03).
8. Tartaglia, Louis A.; Dembski, Marlene; Weng, Xun; Deng, Nanhua; Culpepper, Janice; Devos, Rene; Richards, Grayson J.; Campfield, L.Arthur et al.. (1995-12). «Identification and expression cloning of a leptin receptor, OB-R» Cell 83 (7): 1263–1271.  doi:10.1016/0092-8674(95)90151-5. ISSN 0092-8674. (Noiz kontsultatua: 2021-06-03).
9. (Ingelesez) Winick, Jeffrey D.; Stoffel, Markus; Friedman, Jeffrey M.. (1996-08-15). «Identification of Microsatellite Markers Linked to the Human Leptin Receptor Gene on Chromosome 1» Genomics 36 (1): 221–222.  doi:10.1006/geno.1996.0455. ISSN 0888-7543. (Noiz kontsultatua: 2021-06-03).

Kanpo estekak

• Datuak: Q7072306