Receptor de melatonina 1A

El receptor de melatonina tipo 1A es una proteína que en humanos se codifica por el gen MTNR1A ubicado en el cromosoma 4 (humano) con localización 4q35.2 .^[1]^[2]

Datos rápidos Estructuras disponibles, PDB ...

Estructuras disponibles

PDB

Buscar ortólogos: PDBe, RCSB

Identificadores

Símbolo

MTNR1A (HGNC: 7463)

Identificadores
externos

Locus

Cr. 4 q35.1

Ontología génica


Referencias: AmiGO / QuickGO

Ortólogos

Especies

Humano

Ratón

Entrez

4543

UniProt

P48039

n/a

RefSeq
(ARNm)

NM_005958

n/a

[editar datos en Wikidata]

Cerrar

Funciones

El receptor ML1A o Mel-1A-R (antes llamado MT₁) es un receptor con alta afinidad por la melatonina. Es mediador en las acciones circadianas y reproductivas de la melatonina.^[3]

Véase también

Referencias

[1]
Slaugenhaupt SA, Roca AL, Liebert CB, Altherr MR, Gusella JF, Reppert SM (Nov de 1995). «Mapping of the gene for the Mel1a-melatonin receptor to human chromosome 4 (MTNR1A) and mouse chromosome 8 (Mtnr1a)». Genomics 27 (2): 355-357. PMID 7558006. doi:10.1006/geno.1995.1056.
[2]
«Entrez Gene: MTNR1A melatonin receptor 1A».
[3]
«Mel-1A-R». Uniprot. 2019. Consultado el 30 de agosto de 2020.

Enlaces externos

«Melatonin Receptors: MT₁». IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archivado desde el original el 3 de marzo de 2016.

Léase también

Brzezinski A (1997). «Melatonin in humans.». N. Engl. J. Med. 336 (3): 186-95. PMID 8988899.
Khan AU, Olson DL (1975). «Physical therapy and exercise-induced bronchospasm.». Physical therapy 55 (8): 878-81. PMID 1144527.
Reppert SM, Weaver DR, Ebisawa T (1994). «Cloning and characterization of a mammalian melatonin receptor that mediates reproductive and circadian responses.». Neuron 13 (5): 1177-85. PMID 7946354.
Witt-Enderby PA, Dubocovich ML (1996). «Characterization and regulation of the human ML1A melatonin receptor stably expressed in Chinese hamster ovary cells.». Mol. Pharmacol. 50 (1): 166-74. PMID 8700109.
Witt-Enderby PA, Masana MI, Dubocovich ML (1998). «Physiological exposure to melatonin supersensitizes the cyclic adenosine 3',5'-monophosphate-dependent signal transduction cascade in Chinese hamster ovary cells expressing the human mt1 melatonin receptor.». Endocrinology 139 (7): 3064-71. PMID 9645677.
Ebisawa T, Kajimura N, Uchiyama M, et al. (1999). «Alleic variants of human melatonin 1a receptor: function and prevalence in subjects with circadian rhythm sleep disorders.». Biochem. Biophys. Res. Commun. 262 (3): 832-7. PMID 10471411. doi:10.1006/bbrc.1999.1308.
Brydon L, Roka F, Petit L, et al. (2000). «Dual signaling of human Mel1a melatonin receptors via G(i2), G(i3), and G(q/11) proteins.». Mol. Endocrinol. 13 (12): 2025-38. PMID 10598579.
Niles LP, Wang J, Shen L, et al. (2000). «Melatonin receptor mRNA expression in human granulosa cells.». Mol. Cell. Endocrinol. 156 (1-2): 107-10. PMID 10612428.
Song CK, Bartness TJ (2001). «CNS sympathetic outflow neurons to white fat that express MEL receptors may mediate seasonal adiposity.». Am. J. Physiol. Regul. Integr. Comp. Physiol. 281 (2): R666-72. PMID 11448873.
Roy D, Angelini NL, Fujieda H, et al. (2001). «Cyclical regulation of GnRH gene expression in GT1-7 GnRH-secreting neurons by melatonin.». Endocrinology 142 (11): 4711-20. PMID 11606436.
Savaskan E, Olivieri G, Meier F, et al. (2002). «Increased melatonin 1a-receptor immunoreactivity in the hippocampus of Alzheimer's disease patients.». J. Pineal Res. 32 (1): 59-62. PMID 11841602.
Savaskan E, Wirz-Justice A, Olivieri G, et al. (2002). «Distribution of melatonin MT1 receptor immunoreactivity in human retina.». J. Histochem. Cytochem. 50 (4): 519-26. PMID 11897804.
Ayoub MA, Couturier C, Lucas-Meunier E, et al. (2002). «Monitoring of ligand-independent dimerization and ligand-induced conformational changes of melatonin receptors in living cells by bioluminescence resonance energy transfer.». J. Biol. Chem. 277 (24): 21522-8. PMID 11940583. doi:10.1074/jbc.M200729200.
Yuan L, Collins AR, Dai J, et al. (2003). «MT(1) melatonin receptor overexpression enhances the growth suppressive effect of melatonin in human breast cancer cells.». Mol. Cell. Endocrinol. 192 (1-2): 147-56. PMID 12088876.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). «Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.». Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. PMID 12477932. doi:10.1073/pnas.242603899.
Slominski A, Pisarchik A, Zbytek B, et al. (2003). «Functional activity of serotoninergic and melatoninergic systems expressed in the skin.». J. Cell. Physiol. 196 (1): 144-53. PMID 12767050. doi:10.1002/jcp.10287.
Morcuende JA, Minhas R, Dolan L, et al. (2004). «Allelic variants of human melatonin 1A receptor in patients with familial adolescent idiopathic scoliosis.». Spine 28 (17): 2025-8; discussion 2029. PMID 12973153. doi:10.1097/01.BRS.0000083235.74593.49.
Aust S, Thalhammer T, Humpeler S, et al. (2004). «The melatonin receptor subtype MT1 is expressed in human gallbladder epithelia.». J. Pineal Res. 36 (1): 43-8. PMID 14675129.

Datos: Q18029573

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Referencias

[1]
Slaugenhaupt SA, Roca AL, Liebert CB, Altherr MR, Gusella JF, Reppert SM (Nov de 1995). «Mapping of the gene for the Mel1a-melatonin receptor to human chromosome 4 (MTNR1A) and mouse chromosome 8 (Mtnr1a)». Genomics 27 (2): 355-357. PMID 7558006. doi:10.1006/geno.1995.1056.
[2]
«Entrez Gene: MTNR1A melatonin receptor 1A».
[3]
«Mel-1A-R». Uniprot. 2019. Consultado el 30 de agosto de 2020.

Léase también

Brzezinski A (1997). «Melatonin in humans.». N. Engl. J. Med. 336 (3): 186-95. PMID 8988899.
Khan AU, Olson DL (1975). «Physical therapy and exercise-induced bronchospasm.». Physical therapy 55 (8): 878-81. PMID 1144527.
Reppert SM, Weaver DR, Ebisawa T (1994). «Cloning and characterization of a mammalian melatonin receptor that mediates reproductive and circadian responses.». Neuron 13 (5): 1177-85. PMID 7946354.
Witt-Enderby PA, Dubocovich ML (1996). «Characterization and regulation of the human ML1A melatonin receptor stably expressed in Chinese hamster ovary cells.». Mol. Pharmacol. 50 (1): 166-74. PMID 8700109.
Witt-Enderby PA, Masana MI, Dubocovich ML (1998). «Physiological exposure to melatonin supersensitizes the cyclic adenosine 3',5'-monophosphate-dependent signal transduction cascade in Chinese hamster ovary cells expressing the human mt1 melatonin receptor.». Endocrinology 139 (7): 3064-71. PMID 9645677.
Ebisawa T, Kajimura N, Uchiyama M, et al. (1999). «Alleic variants of human melatonin 1a receptor: function and prevalence in subjects with circadian rhythm sleep disorders.». Biochem. Biophys. Res. Commun. 262 (3): 832-7. PMID 10471411. doi:10.1006/bbrc.1999.1308.
Brydon L, Roka F, Petit L, et al. (2000). «Dual signaling of human Mel1a melatonin receptors via G(i2), G(i3), and G(q/11) proteins.». Mol. Endocrinol. 13 (12): 2025-38. PMID 10598579.
Niles LP, Wang J, Shen L, et al. (2000). «Melatonin receptor mRNA expression in human granulosa cells.». Mol. Cell. Endocrinol. 156 (1-2): 107-10. PMID 10612428.
Song CK, Bartness TJ (2001). «CNS sympathetic outflow neurons to white fat that express MEL receptors may mediate seasonal adiposity.». Am. J. Physiol. Regul. Integr. Comp. Physiol. 281 (2): R666-72. PMID 11448873.
Roy D, Angelini NL, Fujieda H, et al. (2001). «Cyclical regulation of GnRH gene expression in GT1-7 GnRH-secreting neurons by melatonin.». Endocrinology 142 (11): 4711-20. PMID 11606436.
Savaskan E, Olivieri G, Meier F, et al. (2002). «Increased melatonin 1a-receptor immunoreactivity in the hippocampus of Alzheimer's disease patients.». J. Pineal Res. 32 (1): 59-62. PMID 11841602.
Savaskan E, Wirz-Justice A, Olivieri G, et al. (2002). «Distribution of melatonin MT1 receptor immunoreactivity in human retina.». J. Histochem. Cytochem. 50 (4): 519-26. PMID 11897804.
Ayoub MA, Couturier C, Lucas-Meunier E, et al. (2002). «Monitoring of ligand-independent dimerization and ligand-induced conformational changes of melatonin receptors in living cells by bioluminescence resonance energy transfer.». J. Biol. Chem. 277 (24): 21522-8. PMID 11940583. doi:10.1074/jbc.M200729200.
Yuan L, Collins AR, Dai J, et al. (2003). «MT(1) melatonin receptor overexpression enhances the growth suppressive effect of melatonin in human breast cancer cells.». Mol. Cell. Endocrinol. 192 (1-2): 147-56. PMID 12088876.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). «Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.». Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. PMID 12477932. doi:10.1073/pnas.242603899.
Slominski A, Pisarchik A, Zbytek B, et al. (2003). «Functional activity of serotoninergic and melatoninergic systems expressed in the skin.». J. Cell. Physiol. 196 (1): 144-53. PMID 12767050. doi:10.1002/jcp.10287.
Morcuende JA, Minhas R, Dolan L, et al. (2004). «Allelic variants of human melatonin 1A receptor in patients with familial adolescent idiopathic scoliosis.». Spine 28 (17): 2025-8; discussion 2029. PMID 12973153. doi:10.1097/01.BRS.0000083235.74593.49.
Aust S, Thalhammer T, Humpeler S, et al. (2004). «The melatonin receptor subtype MT1 is expressed in human gallbladder epithelia.». J. Pineal Res. 36 (1): 43-8. PMID 14675129.

Datos: Q18029573