La subunidad p105 del factor nuclear NF-kappa-B (NFKB1) es una proteína codificada en humanos por el gen NFKB1.[1]
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Este gen codifica una proteína de 105 kDa que puede sufrir procesamiento co-traduccional el proteasoma 26S para generar una proteína de 50 kDa. La proteína de 105 kDa es un inhibidor Rel específico de transcripción y la de 50 kDa es una subunidad de unión a ADN del complejo proteico NF-κB. NF-κB es un factor de transcripción que es activado por diversos estímulos intra- y extracelulares, tales como citoquinas, radicales libres de oxígeno, radiación UV y productos bacterianos y virales. El complejo NF-κB activado es traslocado al núcleo celular y estimula la expresión de genes implicados en una amplia variedad de procesos biológicos; en torno a 200 genes conocidos son dianas de NF-κB en varios tipos de células diferentes, bajo condiciones específicas. Una activación inapropiada de NF-κB se ha asociado con un cierto número de enfermedades inflamatorias, mientras que una inhibición persistente de NF-κB conduce a un desarrollo incorrecto de células del sistema inmune o un retraso en el crecimiento celular.[2]
La proteína NFKB1 ha demostrado ser capaz de interaccionar con:
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