CBX5

Proteína homóloga cromobox 5
Estructuras disponibles
PDB	Buscar ortólogos: PDBe, RCSB
Identificadores
Símbolos	CBX5 (HGNC: 1555) HP1; HP1-ALPHA; HP1Hs-alpha
Identificadores; externos	OMIM: 604478 ; EBI: CBX5; GeneCards: Gen CBX5; UniProt: CBX5;
Locus	Cr. 12 q13.13
	Referencias: AmiGO / QuickGO
Ortólogos
Humano	Ratón
23468
P45973	n/a
NP_036249	n/a
	v; t; e;
	[editar datos en Wikidata]

La proteína homóloga cromobox 5 (CBX5) es una proteína codificada en humanos por el gen CBX5.^[1]^[2]

Datos rápidos Proteína homóloga cromobox 5, Estructuras disponibles ...

Cerrar

La proteína de heterocromatina 1 (HP1) es una proteína de unión a metil-lisina localizada en sitios con heterocromatina, donde es responsable del silenciamiento de genes.^[2]

La proteína CBX5 ha demostrado ser capaz de interaccionar con:

HDAC9^[3]
Ku70^[4]
MIS12^[5]
Receptor de lámina B^[1]
MBD1^[6]^[7]
TAF4^[8]
Histona deacetilasa 5^[3]
TRIM28^[9]^[10]^[11]^[12]
HDAC4^[3]
CBX3^[11]
SMARCA4^[9]
DNMT3B^[13]
CHAF1A^[7]^[12]
CBX1^[11]
SUV39H1^[6]^[14]^[3]

Proteína de heterocromatina 1

[1]
Ye, Q; Worman H J (Jun. de 1996). «Interaction between an integral protein of the nuclear envelope inner membrane and human chromodomain proteins homologous to Drosophila HP1». J. Biol. Chem. (EE. UU.) 271 (25): 14653-6. ISSN 0021-9258. PMID 8663349.
[2]
«Entrez Gene: CBX5 chromobox homolog 5 (HP1 alpha homolog, Drosophila)».
[3]
Zhang, Chun Li; McKinsey Timothy A, Olson Eric N (Oct. de 2002). «Association of class II histone deacetylases with heterochromatin protein 1: potential role for histone methylation in control of muscle differentiation». Mol. Cell. Biol. (United States) 22 (20): 7302-12. ISSN 0270-7306. PMID 12242305.
[4]
Song, K; Jung Y; Jung D; Lee I (Mar. de 2001). «Human Ku70 interacts with heterochromatin protein 1alpha». J. Biol. Chem. (United States) 276 (11): 8321-7. ISSN 0021-9258. PMID 11112778. doi:10.1074/jbc.M008779200.
[5]
Obuse, Chikashi; Iwasaki Osamu, Kiyomitsu Tomomi, Goshima Gohta, Toyoda Yusuke, Yanagida Mitsuhiro (Nov. de 2004). «A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1». Nat. Cell Biol. (England) 6 (11): 1135-41. ISSN 1465-7392. PMID 15502821. doi:10.1038/ncb1187.
[6]
Fujita, Naoyuki; Watanabe Sugiko, Ichimura Takaya, Tsuruzoe Shu, Shinkai Yoichi, Tachibana Makoto, Chiba Tsutomu, Nakao Mitsuyoshi (Jun. de 2003). «Methyl-CpG binding domain 1 (MBD1) interacts with the Suv39h1-HP1 heterochromatic complex for DNA methylation-based transcriptional repression». J. Biol. Chem. (United States) 278 (26): 24132-8. ISSN 0021-9258. PMID 12711603. doi:10.1074/jbc.M302283200.
[7]
Reese, Brian E; Bachman Kurtis E, Baylin Stephen B, Rountree Michael R (mayo. de 2003). «The methyl-CpG binding protein MBD1 interacts with the p150 subunit of chromatin assembly factor 1». Mol. Cell. Biol. (United States) 23 (9): 3226-36. ISSN 0270-7306. PMID 12697822.
[8]
Vassallo, Milo F; Tanese Naoko (Apr. de 2002). «Isoform-specific interaction of HP1 with human TAFII130». Proc. Natl. Acad. Sci. U.S.A. (United States) 99 (9): 5919-24. ISSN 0027-8424. PMID 11959914. doi:10.1073/pnas.092025499.
[9]
Nielsen, Anders Lade; Sanchez Cecilia, Ichinose Hiroshi, Cerviño Margarita, Lerouge Thierry, Chambon Pierre, Losson Régine (Nov. de 2002). «Selective interaction between the chromatin-remodeling factor BRG1 and the heterochromatin-associated protein HP1alpha». EMBO J. (England) 21 (21): 5797-806. ISSN 0261-4189. PMID 12411497.
[10]
Cammas, Florence; Oulad-Abdelghani Mustapha, Vonesch Jean-Luc, Huss-Garcia Yolande, Chambon Pierre, Losson Régine (Sep. de 2002). «Cell differentiation induces TIF1beta association with centromeric heterochromatin via an HP1 interaction». J. Cell. Sci. (England) 115 (Pt 17): 3439-48. ISSN 0021-9533. PMID 12154074.
[11]
Nielsen, A L; Oulad-Abdelghani M, Ortiz J A, Remboutsika E, Chambon P, Losson R (Apr. de 2001). «Heterochromatin formation in mammalian cells: interaction between histones and HP1 proteins». Mol. Cell (United States) 7 (4): 729-39. ISSN 1097-2765. PMID 11336697.
[12]
Lechner, M S; Begg G E, Speicher D W, Rauscher F J (Sep. de 2000). «Molecular determinants for targeting heterochromatin protein 1-mediated gene silencing: direct chromoshadow domain-KAP-1 corepressor interaction is essential». Mol. Cell. Biol. (UNITED STATES) 20 (17): 6449-65. ISSN 0270-7306. PMID 10938122.
[13]
Lehnertz, Bernhard; Ueda Yoshihide, Derijck Alwin A H A, Braunschweig Ulrich, Perez-Burgos Laura, Kubicek Stefan, Chen Taiping, Li En, Jenuwein Thomas, Peters Antoine H F M (Jul. de 2003). «Suv39h-mediated histone H3 lysine 9 methylation directs DNA methylation to major satellite repeats at pericentric heterochromatin». Curr. Biol. (England) 13 (14): 1192-200. ISSN 0960-9822. PMID 12867029.
[14]
Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (Oct. de 2005). «Towards a proteome-scale map of the human protein-protein interaction network». Nature (England) 437 (7062): 1173-8. PMID 16189514. doi:10.1038/nature04209.

MeSH: CBX5+protein,+human (en inglés)

Datos: Q18037200

[pmid8663349-1] [1]
Ye, Q; Worman H J (Jun. de 1996). «Interaction between an integral protein of the nuclear envelope inner membrane and human chromodomain proteins homologous to Drosophila HP1». J. Biol. Chem. (EE. UU.) 271 (25): 14653-6. ISSN 0021-9258. PMID 8663349.

[entrez-2] [2]
«Entrez Gene: CBX5 chromobox homolog 5 (HP1 alpha homolog, Drosophila)».

[pmid12242305-3] [3]
Zhang, Chun Li; McKinsey Timothy A, Olson Eric N (Oct. de 2002). «Association of class II histone deacetylases with heterochromatin protein 1: potential role for histone methylation in control of muscle differentiation». Mol. Cell. Biol. (United States) 22 (20): 7302-12. ISSN 0270-7306. PMID 12242305.

[pmid11112778-4] [4]
Song, K; Jung Y; Jung D; Lee I (Mar. de 2001). «Human Ku70 interacts with heterochromatin protein 1alpha». J. Biol. Chem. (United States) 276 (11): 8321-7. ISSN 0021-9258. PMID 11112778. doi:10.1074/jbc.M008779200.

[pmid15502821-5] [5]
Obuse, Chikashi; Iwasaki Osamu, Kiyomitsu Tomomi, Goshima Gohta, Toyoda Yusuke, Yanagida Mitsuhiro (Nov. de 2004). «A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1». Nat. Cell Biol. (England) 6 (11): 1135-41. ISSN 1465-7392. PMID 15502821. doi:10.1038/ncb1187.

[pmid12711603-6] [6]
Fujita, Naoyuki; Watanabe Sugiko, Ichimura Takaya, Tsuruzoe Shu, Shinkai Yoichi, Tachibana Makoto, Chiba Tsutomu, Nakao Mitsuyoshi (Jun. de 2003). «Methyl-CpG binding domain 1 (MBD1) interacts with the Suv39h1-HP1 heterochromatic complex for DNA methylation-based transcriptional repression». J. Biol. Chem. (United States) 278 (26): 24132-8. ISSN 0021-9258. PMID 12711603. doi:10.1074/jbc.M302283200.

[pmid12697822-7] [7]
Reese, Brian E; Bachman Kurtis E, Baylin Stephen B, Rountree Michael R (mayo. de 2003). «The methyl-CpG binding protein MBD1 interacts with the p150 subunit of chromatin assembly factor 1». Mol. Cell. Biol. (United States) 23 (9): 3226-36. ISSN 0270-7306. PMID 12697822.

[pmid11959914-8] [8]
Vassallo, Milo F; Tanese Naoko (Apr. de 2002). «Isoform-specific interaction of HP1 with human TAFII130». Proc. Natl. Acad. Sci. U.S.A. (United States) 99 (9): 5919-24. ISSN 0027-8424. PMID 11959914. doi:10.1073/pnas.092025499.

[pmid12411497-9] [9]
Nielsen, Anders Lade; Sanchez Cecilia, Ichinose Hiroshi, Cerviño Margarita, Lerouge Thierry, Chambon Pierre, Losson Régine (Nov. de 2002). «Selective interaction between the chromatin-remodeling factor BRG1 and the heterochromatin-associated protein HP1alpha». EMBO J. (England) 21 (21): 5797-806. ISSN 0261-4189. PMID 12411497.

[pmid12154074-10] [10]
Cammas, Florence; Oulad-Abdelghani Mustapha, Vonesch Jean-Luc, Huss-Garcia Yolande, Chambon Pierre, Losson Régine (Sep. de 2002). «Cell differentiation induces TIF1beta association with centromeric heterochromatin via an HP1 interaction». J. Cell. Sci. (England) 115 (Pt 17): 3439-48. ISSN 0021-9533. PMID 12154074.

[pmid11336697-11] [11]
Nielsen, A L; Oulad-Abdelghani M, Ortiz J A, Remboutsika E, Chambon P, Losson R (Apr. de 2001). «Heterochromatin formation in mammalian cells: interaction between histones and HP1 proteins». Mol. Cell (United States) 7 (4): 729-39. ISSN 1097-2765. PMID 11336697.

[pmid10938122-12] [12]
Lechner, M S; Begg G E, Speicher D W, Rauscher F J (Sep. de 2000). «Molecular determinants for targeting heterochromatin protein 1-mediated gene silencing: direct chromoshadow domain-KAP-1 corepressor interaction is essential». Mol. Cell. Biol. (UNITED STATES) 20 (17): 6449-65. ISSN 0270-7306. PMID 10938122.

[pmid12867029-13] [13]
Lehnertz, Bernhard; Ueda Yoshihide, Derijck Alwin A H A, Braunschweig Ulrich, Perez-Burgos Laura, Kubicek Stefan, Chen Taiping, Li En, Jenuwein Thomas, Peters Antoine H F M (Jul. de 2003). «Suv39h-mediated histone H3 lysine 9 methylation directs DNA methylation to major satellite repeats at pericentric heterochromatin». Curr. Biol. (England) 13 (14): 1192-200. ISSN 0960-9822. PMID 12867029.

[pmid16189514-14] [14]
Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (Oct. de 2005). «Towards a proteome-scale map of the human protein-protein interaction network». Nature (England) 437 (7062): 1173-8. PMID 16189514. doi:10.1038/nature04209.

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CBX5

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Referencias

Enlaces externos