English Noun English Wikipedia has an article on:leading strandWikipedia leading strand (plural leading strands) (genetics) The strand of DNA that is synthesized during replication Related terms lagging strand Translations a strand of new DNA which is synthesized in the same direction as the growing replication fork Chinese: Mandarin: 前导链 (qiándǎo liàn) See also replication forkWikiwand - on Seamless Wikipedia browsing. On steroids.