Unable to move about normally due to illness or injury, especially when confined to bed.
1902, John Buchan, The Outgoing of the Tide:
For days Ailie had an absent eye and a sad face, and it so fell out that in all that time young Heriotside, who had scarce missed a day, was laid up with a broken arm and never came near her.
2000, Arthur Michael Saltzman, This Mad "instead": Governing Metaphors in Contemporary American Fiction, →ISBN, page 12:
Flesh occasionally feels stalemated, more laid up than at home.