ZNF10

Zinc finger protein 10 is a protein that in humans is encoded by the ZNF10 gene.^[3][4][5]

ZNF10
Identifiers
Aliases	ZNF10, KOX1, zinc finger protein 10
External IDs	OMIM: 194538; HomoloGene: 130674; GeneCards: ZNF10; OMA:ZNF10 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q24.33 Start 133,130,575 bp[1] End 133,159,465 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in anterior pituitary testicle right lobe of thyroid gland left lobe of thyroid gland gonad left ovary right uterine tube right ovary body of pancreas gastric mucosa n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding protein binding metal ion binding nucleic acid binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component intracellular anatomical structure nucleus Biological process regulation of transcription, DNA-templated transcription, DNA-templated regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7556 n/a Ensembl ENSG00000256223 n/a UniProt P21506 n/a RefSeq (mRNA) NM_015394 n/a RefSeq (protein) NP_056209 n/a Location (UCSC) Chr 12: 133.13 – 133.16 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Function

The protein encoded by this gene contains a C2H2 zinc finger, and has been shown to function as a transcriptional repressor. The Kruppel-associated box (KRAB) domain of this protein is found to be responsible for its transcriptional repression activity. RING finger containing protein TIF1 was reported to interact with the KRAB domain, and may serve as a mediator for the repression activity of this protein.^[5]

Interactions

ZNF10 has been shown to interact with TRIM28.^[6][7]

References

1. GRCh38: Ensembl release 89: ENSG00000256223 – Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Abrink M, Aveskogh M, Hellman L (Feb 1995). "Isolation of cDNA clones for 42 different Krüppel-related zinc finger proteins expressed in the human monoblast cell line U-937". DNA and Cell Biology. 14 (2): 125–36. doi:10.1089/dna.1995.14.125. PMID 7865130.
4. Rousseau-Merck MF, Hillion J, Jonveaux P, Couillin P, Seité P, Thiesen HJ, Berger R (Dec 1993). "Chromosomal localization of 9 KOX zinc finger genes: physical linkages suggest clustering of KOX genes on chromosomes 12, 16, and 19". Human Genetics. 92 (6): 583–7. doi:10.1007/BF00420943. PMID 8262519. S2CID 19201834.
5. "Entrez Gene: ZNF10 zinc finger protein 10".
6. Moosmann P, Georgiev O, Le Douarin B, Bourquin JP, Schaffner W (Dec 1996). "Transcriptional repression by RING finger protein TIF1 beta that interacts with the KRAB repressor domain of KOX1". Nucleic Acids Research. 24 (24): 4859–67. doi:10.1093/nar/24.24.4859. PMC 146346. PMID 9016654.
7. Peng H, Begg GE, Harper SL, Friedman JR, Speicher DW, Rauscher FJ (Jun 2000). "Biochemical analysis of the Kruppel-associated box (KRAB) transcriptional repression domain". The Journal of Biological Chemistry. 275 (24): 18000–10. doi:10.1074/jbc.M001499200. PMID 10748030.

Further reading

• Huebner K, Druck T, Croce CM, Thiesen HJ (Apr 1991). "Twenty-seven nonoverlapping zinc finger cDNAs from human T cells map to nine different chromosomes with apparent clustering". American Journal of Human Genetics. 48 (4): 726–40. PMC 1682948. PMID 2014798.
• Thiesen HJ (Apr 1990). "Multiple genes encoding zinc finger domains are expressed in human T cells". The New Biologist. 2 (4): 363–74. PMID 2288909.
• Vissing H, Meyer WK, Aagaard L, Tommerup N, Thiesen HJ (Aug 1995). "Repression of transcriptional activity by heterologous KRAB domains present in zinc finger proteins". FEBS Letters. 369 (2–3): 153–7. Bibcode:1995FEBSL.369..153V. doi:10.1016/0014-5793(95)00728-R. PMID 7649249. S2CID 8254920.
• Moosmann P, Georgiev O, Le Douarin B, Bourquin JP, Schaffner W (Dec 1996). "Transcriptional repression by RING finger protein TIF1 beta that interacts with the KRAB repressor domain of KOX1". Nucleic Acids Research. 24 (24): 4859–67. doi:10.1093/nar/24.24.4859. PMC 146346. PMID 9016654.
• Moosmann P, Georgiev O, Thiesen HJ, Hagmann M, Schaffner W (Jul 1997). "Silencing of RNA polymerases II and III-dependent transcription by the KRAB protein domain of KOX1, a Krüppel-type zinc finger factor". Biological Chemistry. 378 (7): 669–77. doi:10.1515/bchm.1997.378.7.669. PMID 9278146.
• Peng H, Begg GE, Harper SL, Friedman JR, Speicher DW, Rauscher FJ (Jun 2000). "Biochemical analysis of the Kruppel-associated box (KRAB) transcriptional repression domain". The Journal of Biological Chemistry. 275 (24): 18000–10. doi:10.1074/jbc.M001499200. PMID 10748030.
• Lorenz P, Koczan D, Thiesen HJ (Apr 2001). "Transcriptional repression mediated by the KRAB domain of the human C2H2 zinc finger protein Kox1/ZNF10 does not require histone deacetylation". Biological Chemistry. 382 (4): 637–44. doi:10.1515/BC.2001.075. PMID 11405226. S2CID 13200652.

External links

• ZNF10+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.