ZNF10

Zinc finger protein 10 is a protein that in humans is encoded by the ZNF10 gene.^[3][4][5]

ZNF10
Identifiers
Aliases	ZNF10, KOX1, zinc finger protein 10
External IDs	OMIM: 194538; HomoloGene: 130674; GeneCards: ZNF10; OMA:ZNF10 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q24.33 Start 133,130,575 bp[1] End 133,159,465 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in anterior pituitary testicle right lobe of thyroid gland left lobe of thyroid gland gonad left ovary right uterine tube right ovary body of pancreas gastric mucosa n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding protein binding metal ion binding nucleic acid binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component intracellular anatomical structure nucleus Biological process regulation of transcription, DNA-templated transcription, DNA-templated regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7556 n/a Ensembl ENSG00000256223 n/a UniProt P21506 n/a RefSeq (mRNA) NM_015394 n/a RefSeq (protein) NP_056209 n/a Location (UCSC) Chr 12: 133.13 – 133.16 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Function

The protein encoded by this gene contains a C2H2 zinc finger, and has been shown to function as a transcriptional repressor. The Kruppel-associated box (KRAB) domain of this protein is found to be responsible for its transcriptional repression activity. RING finger containing protein TIF1 was reported to interact with the KRAB domain, and may serve as a mediator for the repression activity of this protein.^[5]

Interactions

ZNF10 has been shown to interact with TRIM28.^[6][7]