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Chemical compound From Wikipedia, the free encyclopedia
ZK-93426 (ethyl-5-isopropoxy-4-methyl-beta-carboline-3-carboxylate) is a drug from the beta-carboline family. It acts as a weak partial inverse agonist of benzodiazepine receptors,[1] meaning that it causes the opposite effects to the benzodiazepine class of drugs and has anxiogenic properties,[2] although unlike most benzodiazepine antagonists it is not a convulsant and actually has weak anticonvulsant effects.[3] In human tests it produced alertness, restlessness and feelings of apprehension[clarification needed], and reversed the effect of the benzodiazepine lormetazepam.[4][5] It was also shown to produce nootropic effects[6][7] and increased release of acetylcholine.[8][9]
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Preferred IUPAC name
Ethyl 4-methyl-5-[(propan-2-yl)oxy]-9H-pyrido[3,4-b]indole-3-carboxylate | |
Other names
ZK-93426 Ethyl 5-isopropoxy-4-methyl-9H-β-carboline-3-carboxylate | |
Identifiers | |
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CompTox Dashboard (EPA) |
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Properties | |
C18H20N2O3 | |
Molar mass | 314.336 g/mol |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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