ZBTB7A

Zinc finger and BTB domain-containing protein 7A is a protein that in humans is encoded by the ZBTB7A gene.^[5][6][7]

ZBTB7A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2IF5, 2NN2
Identifiers
Aliases	ZBTB7A, FBI-1, FBI1, LRF, ZBTB7, ZNF857A, pokemon, TIP21, zinc finger and BTB domain containing 7A, MNDLFH
External IDs	OMIM: 605878; MGI: 1335091; HomoloGene: 7820; GeneCards: ZBTB7A; OMA:ZBTB7A - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.3 Start 4,043,303 bp[1] End 4,066,899 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 C1 Start 80,971,054 bp[2] End 80,988,829 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in nipple internal globus pallidus middle temporal gyrus pylorus cerebellar vermis Brodmann area 23 cardia vulva superior surface of tongue ventral tegmental area Top expressed in ascending aorta aortic valve inner renal medulla superior frontal gyrus glomerulus lip granulocyte right kidney esophagus cerebellar cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA binding DNA-binding transcription repressor activity, RNA polymerase II-specific protein binding histone acetyltransferase binding metal ion binding nucleic acid binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription corepressor binding DNA-binding transcription factor activity transcription corepressor activity sequence-specific DNA binding SMAD binding androgen receptor binding Cellular component nucleus cytoplasm NuRD complex site of double-strand break DNA-dependent protein kinase complex Biological process multicellular organism development cell differentiation negative regulation of transcription, DNA-templated regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II transcription, DNA-templated regulation of alternative mRNA splicing, via spliceosome regulation of glycolytic process chromatin organization chromatin remodeling cellular response to DNA damage stimulus B cell differentiation negative regulation of transforming growth factor beta receptor signaling pathway protein localization to nucleus regulation of apoptotic process erythrocyte maturation fat cell differentiation negative regulation of Notch signaling pathway regulation of DNA-binding transcription factor activity positive regulation of NF-kappaB transcription factor activity negative regulation of androgen receptor signaling pathway double-strand break repair via classical nonhomologous end joining regulation of transcription regulatory region DNA binding Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51341 16969 Ensembl ENSG00000178951 ENSMUSG00000035011 UniProt O95365 O88939 RefSeq (mRNA) NM_015898 NM_001317990 NM_020224 NM_010731 RefSeq (protein) NP_001304919 NP_056982 NP_034861 NP_001391790 NP_001391791 NP_001391792 NP_001391793 NP_001391794 NP_001391795 NP_001391796 Location (UCSC) Chr 19: 4.04 – 4.07 Mb Chr 10: 80.97 – 80.99 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

ZBTB7A has been shown to interact with BCL6.^[8]

See also

• Zbtb7

References

1. GRCh38: Ensembl release 89: ENSG00000178951 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000035011 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Morrison DJ, Pendergrast PS, Stavropoulos P, Colmenares SU, Kobayashi R, Hernandez N (Apr 1999). "FBI-1, a factor that binds to the HIV-1 inducer of short transcripts (IST), is a POZ domain protein". Nucleic Acids Res. 27 (5): 1251–62. doi:10.1093/nar/27.5.1251. PMC 148309. PMID 9973611.
6. Davies JM, Hawe N, Kabarowski J, Huang QH, Zhu J, Brand NJ, Leprince D, Dhordain P, Cook M, Morriss-Kay G, Zelent A (Feb 1999). "Novel BTB/POZ domain zinc-finger protein, LRF, is a potential target of the LAZ-3/BCL-6 oncogene". Oncogene. 18 (2): 365–75. doi:10.1038/sj.onc.1202332. PMID 9927193. S2CID 5769828.
7. "Entrez Gene: ZBTB7A zinc finger and BTB domain containing 7A".
8. Davies JM, Hawe N, Kabarowski J, Huang QH, Zhu J, Brand NJ, Leprince D, Dhordain P, Cook M, Morriss-Kay G, Zelent A (January 1999). "Novel BTB/POZ domain zinc-finger protein, LRF, is a potential target of the LAZ-3/BCL-6 oncogene". Oncogene. 18 (2): 365–75. doi:10.1038/sj.onc.1202332. PMID 9927193. S2CID 5769828.

Further reading

• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Pendergrast PS, Wang C, Hernandez N, Huang S (2002). "FBI-1 Can Stimulate HIV-1 Tat Activity and Is Targeted to a Novel Subnuclear Domain that Includes the Tat-P-TEFb—containing Nuclear Speckles". Mol. Biol. Cell. 13 (3): 915–29. doi:10.1091/mbc.01-08-0383. PMC 99609. PMID 11907272.
• Lee DK, Suh D, Edenberg HJ, Hur MW (2002). "POZ domain transcription factor, FBI-1, represses transcription of ADH5/FDH by interacting with the zinc finger and interfering with DNA binding activity of Sp1". J. Biol. Chem. 277 (30): 26761–8. doi:10.1074/jbc.M202078200. PMID 12004059.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Pessler F, Hernandez N (2003). "Flexible DNA binding of the BTB/POZ-domain protein FBI-1". J. Biol. Chem. 278 (31): 29327–35. doi:10.1074/jbc.M302980200. PMID 12750370.
• Laudes M, Christodoulides C, Sewter C, et al. (2004). "Role of the POZ zinc finger transcription factor FBI-1 in human and murine adipogenesis". J. Biol. Chem. 279 (12): 11711–8. doi:10.1074/jbc.M310240200. PMC 4303998. PMID 14701838.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Liu CJ, Prazak L, Fajardo M, et al. (2004). "Leukemia/lymphoma-related factor, a POZ domain-containing transcriptional repressor, interacts with histone deacetylase-1 and inhibits cartilage oligomeric matrix protein gene expression and chondrogenesis". J. Biol. Chem. 279 (45): 47081–91. doi:10.1074/jbc.M405288200. PMID 15337766.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Maeda T, Hobbs RM, Merghoub T, et al. (2005). "Role of the proto-oncogene Pokémon in cellular transformation and ARF repression". Nature. 433 (7023): 278–85. Bibcode:2005Natur.433..278M. doi:10.1038/nature03203. PMID 15662416. S2CID 4308742.
• Lee DK, Kang JE, Park HJ, et al. (2005). "FBI-1 enhances transcription of the nuclear factor-kappaB (NF-kappaB)-responsive E-selectin gene by nuclear localization of the p65 subunit of NF-kappaB". J. Biol. Chem. 280 (30): 27783–91. doi:10.1074/jbc.M504909200. PMID 15917220.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
• Roh HE, Lee MN, Jeon BN, et al. (2007). "Regulation of Pokémon 1 activity by sumoylation". Cell. Physiol. Biochem. 20 (1–4): 167–80. doi:10.1159/000104164. PMID 17595526.

External links

• ZBTB7A+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• FactorBook ZBTB7A

This article incorporates text from the United States National Library of Medicine, which is in the public domain.