WNT9A

Protein Wnt-9a (formerly Wnt14^[5]) is a protein that in humans is encoded by the WNT9A gene.^[6][7]

WNT9A
Identifiers
Aliases	WNT9A, WNT14, Wnt family member 9A
External IDs	OMIM: 602863; MGI: 2446084; HomoloGene: 20722; GeneCards: WNT9A; OMA:WNT9A - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q42.13 Start 227,918,656 bp[1] End 227,947,932 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 B1.3 Start 59,197,754 bp[2] End 59,224,378 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in decidua oocyte gastrocnemius muscle muscle of thigh tendon of biceps brachii parotid gland muscle layer of sigmoid colon secondary oocyte tibialis anterior muscle mucosa of paranasal sinus Top expressed in urethra lumbar spinal ganglion ramus of the mandible lamina propria of urethra prostatic urethra muscle layer of urethra muscle layer of seminal vesicle muscular layer of prostatic urethra tibialis anterior muscle triceps brachii muscle More reference expression data BioGPS n/a
Gene ontology Molecular function frizzled binding signaling receptor binding receptor ligand activity Cellular component extracellular region extracellular space Biological process embryonic skeletal system morphogenesis cellular response to retinoic acid cell fate commitment negative regulation of cysteine-type endopeptidase activity involved in apoptotic process negative regulation of cartilage development embryonic skeletal joint development positive regulation of smoothened signaling pathway anatomical structure development mitotic cell cycle checkpoint signaling iris morphogenesis cornea development in camera-type eye cell-cell signaling negative regulation of cell death multicellular organism development negative regulation of chondrocyte differentiation positive regulation of cell differentiation neuron differentiation embryonic forelimb morphogenesis negative regulation of cell population proliferation Wnt signaling pathway regulation of signaling receptor activity canonical Wnt signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7483 216795 Ensembl ENSG00000143816 ENSMUSG00000000126 UniProt O14904 Q8R5M2 RefSeq (mRNA) NM_003395 NM_139298 RefSeq (protein) NP_003386 NP_647459 Location (UCSC) Chr 1: 227.92 – 227.95 Mb Chr 11: 59.2 – 59.22 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is expressed in gastric cancer cell lines. The protein encoded by this gene shows 75% amino acid identity to chicken Wnt14, which has been shown to play a central role in initiating synovial joint formation in the chick limb. This gene is clustered with another family member, WNT3A, in the chromosome 1q42 region.^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000143816 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000000126 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Person AD, Garriock RJ, Krieg PA, Runyan RB, Klewer SE (2005). "Frzb modulates Wnt-9a-mediated beta-catenin signaling during avian atrioventricular cardiac cushion development". Developmental Biology. 278 (1): 35–48. doi:10.1016/j.ydbio.2004.10.013. PMID 15649459.
6. Bergstein I, Eisenberg LM, Bhalerao J, Jenkins NA, Copeland NG, Osborne MP, Bowcock AM, Brown AM (Mar 1998). "Isolation of two novel WNT genes, WNT14 and WNT15, one of which (WNT15) is closely linked to WNT3 on human chromosome 17q21". Genomics. 46 (3): 450–8. doi:10.1006/geno.1997.5041. PMID 9441749.
7. "Entrez Gene: WNT9A wingless-type MMTV integration site family, member 9A".

Further reading

• Smolich BD, McMahon JA, McMahon AP, Papkoff J (1994). "Wnt family proteins are secreted and associated with the cell surface". Mol. Biol. Cell. 4 (12): 1267–75. doi:10.1091/mbc.4.12.1267. PMC 275763. PMID 8167409.
• Hartmann C, Tabin CJ (2001). "Wnt-14 plays a pivotal role in inducing synovial joint formation in the developing appendicular skeleton". Cell. 104 (3): 341–51. doi:10.1016/S0092-8674(01)00222-7. PMID 11239392. S2CID 7027914.
• Saitoh T, Hirai M, Katoh M (2001). "Molecular cloning and characterization of WNT3A and WNT14 clustered in human chromosome 1q42 region". Biochem. Biophys. Res. Commun. 284 (5): 1168–75. doi:10.1006/bbrc.2001.5105. PMID 11414706.
• Katoh M (2002). "Molecular cloning and expression of mouse Wnt14, and structural comparison between mouse Wnt14-Wnt3a gene cluster and human WNT14-WNT3A gene cluster". Int. J. Mol. Med. 9 (3): 221–7. doi:10.3892/ijmm.9.3.221. PMID 11836627.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Qian J, Jiang Z, Li M, et al. (2003). "Mouse Wnt9b transforming activity, tissue-specific expression, and evolution". Genomics. 81 (1): 34–46. doi:10.1016/S0888-7543(02)00012-5. PMID 12573259.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Katoh Y, Katoh M (2005). "Comparative genomics on Wnt9a orthologs". Oncol. Rep. 13 (5): 989–92. doi:10.3892/or.13.5.989. PMID 15809769.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
• Bhattacharyya S, Borthakur A, Dudeja PK, Tobacman JK (2007). "Carrageenan reduces bone morphogenetic protein-4 (BMP4) and activates the Wnt/beta-catenin pathway in normal human colonocytes". Dig. Dis. Sci. 52 (10): 2766–74. doi:10.1007/s10620-006-9531-4. PMID 17429723. S2CID 30200056.