WNT11

Protein Wnt-11 is a protein that in humans is encoded by the WNT11 gene.^[5][6]

WNT11
Identifiers
Aliases	WNT11, HWnt family member 11
External IDs	OMIM: 603699; MGI: 101948; HomoloGene: 20970; GeneCards: WNT11; OMA:WNT11 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q13.5 Start 76,186,325 bp[1] End 76,210,736 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 E1|7 53.9 cM Start 98,484,319 bp[2] End 98,504,402 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in muscle of thigh subcutaneous adipose tissue right adrenal cortex left adrenal cortex testicle right lobe of thyroid gland apex of heart gastrocnemius muscle left lobe of thyroid gland tendon Top expressed in lip muscle layer of urethra mucous cell of stomach muscle layer of ejaculatory duct muscle of thigh muscle layer of seminal vesicle pyloric antrum external carotid artery hair right ventricle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function GTPase activator activity frizzled binding protein kinase activator activity protein binding signaling receptor binding Cellular component extracellular region extracellular space cytoplasm extracellular matrix Biological process ureteric bud morphogenesis cellular response to retinoic acid bone mineralization cell differentiation non-canonical Wnt signaling pathway cell fate commitment negative regulation of cartilage development paraxial mesoderm formation mesonephric duct development convergent extension involved in axis elongation positive regulation of protein kinase C signaling kidney development positive regulation of cell migration ventricular septum morphogenesis outflow tract morphogenesis negative regulation of apoptotic process negative regulation of cell death adrenal gland development planar cell polarity pathway involved in axis elongation positive regulation of transforming growth factor beta2 production somite development embryonic skeletal system development positive regulation of transcription, DNA-templated multicellular organism development protein phosphorylation positive regulation of GTPase activity maintenance of epithelial cell apical/basal polarity positive regulation of gene expression Wnt signaling pathway, calcium modulating pathway negative regulation of cell migration response to nutrient levels protein localization to cell surface notochord morphogenesis negative regulation of cell growth osteoblast differentiation neuron differentiation artery morphogenesis bicellular tight junction assembly epithelial to mesenchymal transition positive regulation of apoptotic process canonical Wnt signaling pathway lung-associated mesenchyme development negative regulation of transcription, DNA-templated cloacal septation negative regulation of mesenchymal cell proliferation neuroendocrine cell differentiation negative regulation of canonical Wnt signaling pathway negative regulation of fibroblast growth factor production positive regulation of stress fiber assembly planar cell polarity pathway involved in gastrula mediolateral intercalation Wnt signaling pathway, planar cell polarity pathway Wnt signaling pathway activation of protein kinase activity cellular response to mechanical stimulus roof of mouth development secondary palate development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7481 22411 Ensembl ENSG00000085741 ENSMUSG00000015957 UniProt O96014 P48615 RefSeq (mRNA) NM_004626 NM_001285792 NM_001285794 NM_001285795 NM_009519 RefSeq (protein) NP_004617 NP_001272721 NP_001272723 NP_001272724 NP_033545 Location (UCSC) Chr 11: 76.19 – 76.21 Mb Chr 7: 98.48 – 98.5 Mb PubMed search [3] [4]
Wikidata
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The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein showing 97%, 85%, and 63% amino acid identity with mouse, chicken, and Xenopus Wnt11 protein, respectively. This gene plays roles in the development of bones, kidneys,^[7] and lungs,^[8] and is associated with early onset osteoporosis. ^[9]

References

1. GRCh38: Ensembl release 89: ENSG00000085741 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000015957 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Lako M, Strachan T, Bullen P, Wilson DI, Robson SC, Lindsay S (Dec 1998). "Isolation, characterisation and embryonic expression of WNT11, a gene which maps to 11q13.5 and has possible roles in the development of skeleton, kidney and lung". Gene. 219 (1–2): 101–10. doi:10.1016/S0378-1119(98)00393-X. PMID 9757009.
6. "Entrez Gene: WNT11 wingless-type MMTV integration site family, member 11".
7. Majumdar A, Vainio S, Kispert A, McMahon J, McMahon AP (2003-07-15). "Wnt11andRet/Gdnfpathways cooperate in regulating ureteric branching during metanephric kidney development". Development. 130 (14). The Company of Biologists: 3175–3185. doi:10.1242/dev.00520. ISSN 1477-9129. PMID 12783789. S2CID 25866889.
8. Lako M, Strachan T, Bullen P, Wilson D, Robson S, Lindsay S (1998). "Isolation, characterisation and embryonic expression of WNT11, a gene which maps to 11q13.5 and has possible roles in the development of skeleton, kidney and lung". Gene. 219 (1–2). Elsevier BV: 101–110. doi:10.1016/s0378-1119(98)00393-x. ISSN 0378-1119. PMID 9757009.
9. Caetano da Silva C, Edouard T, Fradin M, Aubert-Mucca M, Ricquebourg M, Raman R, Salles JP, Charon V, Guggenbuhl P, Muller M, Cohen-Solal M, Collet C (2021-12-07). "WNT11, a new gene associated with early onset osteoporosis, is required for osteoblastogenesis". Human Molecular Genetics. 31 (10). Oxford University Press (OUP): 1622–1634. doi:10.1093/hmg/ddab349. ISSN 0964-6906. PMC 9122655. PMID 34875064.

Further reading

• Smolich BD, McMahon JA, McMahon AP, Papkoff J (1994). "Wnt family proteins are secreted and associated with the cell surface". Mol. Biol. Cell. 4 (12): 1267–75. doi:10.1091/mbc.4.12.1267. PMC 275763. PMID 8167409.
• Kirikoshi H, Sekihara H, Katoh M (2002). "Molecular cloning and characterization of human WNT11". Int. J. Mol. Med. 8 (6): 651–6. doi:10.3892/ijmm.8.6.651. PMID 11712081.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ouko L, Ziegler TR, Gu LH, et al. (2004). "Wnt11 signaling promotes proliferation, transformation, and migration of IEC6 intestinal epithelial cells". J. Biol. Chem. 279 (25): 26707–15. doi:10.1074/jbc.M402877200. PMC 1351009. PMID 15084607.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Kim SW, Park JI, Spring CM, et al. (2005). "Non-canonical Wnt signals are modulated by the Kaiso transcriptional repressor and p120-catenin". Nat. Cell Biol. 6 (12): 1212–20. doi:10.1038/ncb1191. PMID 15543138. S2CID 19404686.
• Koyanagi M, Haendeler J, Badorff C, et al. (2005). "Non-canonical Wnt signaling enhances differentiation of human circulating progenitor cells to cardiomyogenic cells". J. Biol. Chem. 280 (17): 16838–42. doi:10.1074/jbc.M500323200. PMID 15701629.
• Garriock RJ, D'Agostino SL, Pilcher KC, Krieg PA (2005). "Wnt11-R, a protein closely related to mammalian Wnt11, is required for heart morphogenesis in Xenopus". Dev. Biol. 279 (1): 179–92. doi:10.1016/j.ydbio.2004.12.013. PMID 15708567.
• Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
• Panáková D, Werdich AA, Macrae CA (2010). "Wnt11 patterns a myocardial electrical gradient through regulation of the L-type Ca(2+) channel". Nature. 466 (8): 874–878. Bibcode:2010Natur.466..874P. doi:10.1038/nature09249. PMC 2921013. PMID 20657579.