WIF1

Wnt inhibitory factor 1 is a protein that in humans is encoded by the WIF1 gene.^[5] WIF1 is a lipid-binding protein that binds to Wnt proteins and prevents them from triggering signalling.^[6][7][8]

WIF1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2D3J, 2YGN, 2YGO, 2YGP, 2YGQ
Identifiers
Aliases	WIF1, WIF-1, WNT inhibitory factor 1
External IDs	OMIM: 605186; MGI: 1344332; HomoloGene: 31430; GeneCards: WIF1; OMA:WIF1 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q14.3 Start 65,050,626 bp[1] End 65,121,305 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 D2 Start 120,869,865 bp[2] End 120,936,555 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in lower lobe of lung periodontal fiber tibia parotid gland caudate nucleus putamen corpus epididymis tail of epididymis nucleus accumbens trabecular bone Top expressed in molar skin of external ear dermis body of femur seminal vesicula intercostal muscle trachea ankle calvaria conjunctival fornix More reference expression data BioGPS More reference expression data
Gene ontology Molecular function Wnt-protein binding protein binding signaling receptor binding Cellular component extracellular region cell surface Biological process multicellular organism development negative regulation of Wnt signaling pathway Wnt signaling pathway signal transduction positive regulation of fat cell differentiation anatomical structure development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11197 24117 Ensembl ENSG00000156076 ENSMUSG00000020218 UniProt Q9Y5W5 Q9WUA1 RefSeq (mRNA) NM_007191 NM_011915 RefSeq (protein) NP_009122 NP_036045 Location (UCSC) Chr 12: 65.05 – 65.12 Mb Chr 10: 120.87 – 120.94 Mb PubMed search [3] [4]
Wikidata
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Function

WNT proteins are extracellular signaling molecules involved in the control of embryonic development. This gene encodes a secreted protein, which binds WNT proteins and inhibits their activities. This protein contains a WNT inhibitory factor (WIF) domain and 5 epidermal growth factor (EGF)-like domains. It may be involved in mesoderm segmentation. This protein is found to be present in fish, amphibia and mammals.^[5]