WFDC1

WAP four-disulfide core domain protein 1 is a protein that in humans is encoded by the WFDC1 gene.^[5][6]

WFDC1
Identifiers
Aliases	WFDC1, PS20, WAP four-disulfide core domain 1
External IDs	OMIM: 605322; MGI: 1915116; HomoloGene: 10920; GeneCards: WFDC1; OMA:WFDC1 - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16q24.1 Start 84,294,846 bp[1] End 84,329,844 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 E1 Start 120,393,104 bp[2] End 120,414,961 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in saphenous vein right coronary artery seminal vesicula retinal pigment epithelium nipple popliteal artery tibial arteries urethra cardia mucosa of urinary bladder Top expressed in temporal muscle muscle of thigh triceps brachii muscle skeletal muscle tissue sternocleidomastoid muscle digastric muscle medial head of gastrocnemius muscle soleus muscle quadriceps femoris muscle lens More reference expression data BioGPS More reference expression data
Gene ontology Molecular function peptidase inhibitor activity serine-type endopeptidase inhibitor activity molecular function Cellular component extracellular region extracellular space Biological process negative regulation of wound healing negative regulation of peptidase activity response to estradiol negative regulation of inflammatory response negative regulation of cell growth regulation of cell growth negative regulation of endopeptidase activity negative regulation of epithelial cell proliferation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 58189 67866 Ensembl ENSG00000103175 ENSMUSG00000023336 UniProt Q9HC57 Q9ESH5 RefSeq (mRNA) NM_001282466 NM_001282467 NM_021197 NM_023395 RefSeq (protein) NP_001269395 NP_001269396 NP_067020 NP_075884 Location (UCSC) Chr 16: 84.29 – 84.33 Mb Chr 8: 120.39 – 120.41 Mb PubMed search [3] [4]
Wikidata
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This gene encodes a member of the WAP-type four disulfide core domain family. The WAP-type four-disulfide core domain, or WAP signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor in many family members. The encoded protein shares 81% amino acid identity with the rat ps20 protein, which was originally identified as a secreted growth inhibitor. This gene is mapped to chromosome 16q24, an area of frequent loss of heterozygosity in cancers, including prostate, breast and hepatocellular cancers and Wilms' tumor. Owing to its location and a possible growth inhibitory property of its gene product, this gene is suggested to be a tumor suppressor gene.^[6]