VectorBase

VectorBase^[1][2] is one of the five Bioinformatics Resource Centers (BRC) funded by the National Institute of Allergy and Infectious Diseases (NIAID), a component of the National Institutes of Health (NIH), which is an agency of the United States Department of Health and Human Services. VectorBase is focused on invertebrate vectors of human pathogens working with the sequencing centers and the research community to curate vector genomes (mainly genome annotation).

Genomes covered in the VectorBase database

• Aedes aegypti^[3]
• Anopheles gambiae^[4]
• Culex quinquefasciatus
• Ixodes scapularis
• Pediculus humanus
• Rhodnius prolixus

Tools available through the VectorBase site

• Genome browser
• Community annotation system
• Microarray and gene expression repository
• Controlled vocabularies for anatomy,^[5] insecticide resistance and vector-borne diseases (malaria and dengue fever)
• BLAST searches for all covered genomes

See also

• Vectors in epidemiology

References

1. Lawson, D; Arensburger, P; Atkinson, P; Besansky, NJ; Bruggner, RV; Butler, R; Campbell, KS; Christophides, GK; et al. (2007). "VectorBase: a home for invertebrate vectors of human pathogens". Nucleic Acids Research. 35 (Database issue): D503–5. doi:10.1093/nar/gkl960. PMC 1751530. PMID 17145709.
2. Lawson, D; Arensburger, P; Atkinson, P; Besansky, NJ; Bruggner, RV; Butler, R; Campbell, KS; Christophides, GK; et al. (2009). "VectorBase: a data resource for invertebrate vector genomics". Nucleic Acids Research. 37 (Database issue): D583–7. doi:10.1093/nar/gkn857. PMC 2686483. PMID 19028744.
3. Nene, V; Wortman, JR; Lawson, D; Haas, B; Kodira, C; Tu, ZJ; Loftus, B; Xi, Z; et al. (2007). "Genome sequence of Aedes aegypti, a major arbovirus vector". Science. 316 (5832): 1718–23. Bibcode:2007Sci...316.1718N. doi:10.1126/science.1138878. PMC 2868357. PMID 17510324.
4. Holt, RA; Subramanian, GM; Halpern, A; Sutton, GG; Charlab, R; Nusskern, DR; Wincker, P; Clark, AG; et al. (2002). "The genome sequence of the malaria mosquito Anopheles gambiae". Science. 298 (5591): 129–49. Bibcode:2002Sci...298..129H. CiteSeerX 10.1.1.149.9058. doi:10.1126/science.1076181. PMID 12364791. S2CID 4512225.
5. Topalis, P; Tzavlaki, C; Vestaki, K; Dialynas, E; Sonenshine, DE; Butler, R; Bruggner, RV; Stinson, EO; et al. (2008). "Anatomical ontologies of mosquitoes and ticks, and their web browsers in VectorBase". Insect Molecular Biology. 17 (1): 87–9. doi:10.1111/j.1365-2583.2008.00781.x. PMID 18237287. S2CID 8618269.

External links

• vectorbase.org
• Bioinformatics Resource Centers The NIAID page describing the goals and activities of the BRCs
• Pathogen Portal Hub site for the five BRCs; provides summary information

VectorBase genome browsers

• Aedes aegypti genome browser at VectorBase
• Anopheles gambiae genome browser at VectorBase
• Culex quinquefasciatus genome browser at VectorBase
• Ixodes scapularis genome browser at VectorBase
• Pediculus humanus genome browser at VectorBase
• Rhodnius prolixus genome browser at VectorBase