VPRBP

Protein VPRBP is a protein that in humans is encoded by the VPRBP gene.^[5][6][7]

DCAF1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3WA0, 4CC9, 4P7I, 4PXW, 4Z8L, 5AJA
Identifiers
Aliases	DCAF1, VPRBP, Vpr (HIV-1) binding protein, DDB1 and CUL4 associated factor 1, RIP
External IDs	OMIM: 617259; MGI: 2445220; HomoloGene: 8805; GeneCards: DCAF1; OMA:DCAF1 - orthologs
EC number	2.7.11.1
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p21.2 Start 51,395,867 bp[1] End 51,500,015 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 F1 Start 106,699,073 bp[2] End 106,758,191 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm right testis left testis pericardium tendon of biceps brachii vena cava ventricular zone gastrocnemius muscle Skeletal muscle tissue of rectus abdominis ganglionic eminence Top expressed in genital tubercle tail of embryo zygote spermatid secondary oocyte spermatocyte CA3 field lactiferous gland entorhinal cortex perirhinal cortex More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity nucleotide binding kinase activity histone kinase activity (H2A-T120 specific) protein serine/threonine kinase activity protein binding ATP binding estrogen receptor binding Cellular component cytoplasm COP9 signalosome nucleus fibrillar center Cul4-RING E3 ubiquitin ligase complex Biological process regulation of transcription, DNA-templated phosphorylation negative regulation of transcription by RNA polymerase II transcription, DNA-templated cell competition in a multicellular organism protein ubiquitination V(D)J recombination B cell differentiation viral process chromatin organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9730 321006 Ensembl ENSG00000145041 ENSMUSG00000040325 UniProt Q9Y4B6 Q80TR8 RefSeq (mRNA) NM_001171904 NM_014703 NM_001349168 NM_001349169 NM_001349170 NM_001349171 NM_001387578 NM_001387579 NM_001387580 NM_001387581 NM_001387582 NM_001387583 NM_001015507 NM_001373930 NM_001373931 RefSeq (protein) NP_001165375 NP_055518 NP_001336097 NP_001336098 NP_001336099 NP_001336100 NP_001015507 NP_001360859 NP_001360860 Location (UCSC) Chr 3: 51.4 – 51.5 Mb Chr 9: 106.7 – 106.76 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

VPRBP has been shown to interact with Merlin.^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000145041 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000040325 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Zhao LJ, Mukherjee S, Narayan O (June 1994). "Biochemical mechanism of HIV-I Vpr function. Specific interaction with a cellular protein". The Journal of Biological Chemistry. 269 (22): 15577–82. doi:10.1016/S0021-9258(17)40719-8. PMID 8195203.
6. Zhang S, Feng Y, Narayan O, Zhao LJ (January 2001). "Cytoplasmic retention of HIV-1 regulatory protein Vpr by protein-protein interaction with a novel human cytoplasmic protein VprBP". Gene. 263 (1–2): 131–40. doi:10.1016/S0378-1119(00)00583-7. PMID 11223251.
7. "Entrez Gene: VPRBP Vpr (HIV-1) binding protein".
8. Huang J, Chen J (July 2008). "VprBP targets Merlin to the Roc1-Cul4A-DDB1 E3 ligase complex for degradation". Oncogene. 27 (29): 4056–64. doi:10.1038/onc.2008.44. PMID 18332868.

Further reading

• Tan L, Ehrlich E, Yu XF (October 2007). "DDB1 and Cul4A are required for human immunodeficiency virus type 1 Vpr-induced G2 arrest". Journal of Virology. 81 (19): 10822–30. doi:10.1128/JVI.01380-07. PMC 2045451. PMID 17626091.
• Wen X, Duus KM, Friedrich TD, de Noronha CM (September 2007). "The HIV1 protein Vpr acts to promote G2 cell cycle arrest by engaging a DDB1 and Cullin4A-containing ubiquitin ligase complex using VprBP/DCAF1 as an adaptor". The Journal of Biological Chemistry. 282 (37): 27046–57. doi:10.1074/jbc.M703955200. PMID 17620334.
• Hrecka K, Gierszewska M, Srivastava S, Kozaczkiewicz L, Swanson SK, Florens L, Washburn MP, Skowronski J (July 2007). "Lentiviral Vpr usurps Cul4-DDB1[VprBP] E3 ubiquitin ligase to modulate cell cycle". Proceedings of the National Academy of Sciences of the United States of America. 104 (28): 11778–83. Bibcode:2007PNAS..10411778H. doi:10.1073/pnas.0702102104. PMC 1906728. PMID 17609381.
• Le Rouzic E, Belaïdouni N, Estrabaud E, Morel M, Rain JC, Transy C, Margottin-Goguet F (January 2007). "HIV1 Vpr arrests the cell cycle by recruiting DCAF1/VprBP, a receptor of the Cul4-DDB1 ubiquitin ligase". Cell Cycle. 6 (2): 182–8. doi:10.4161/cc.6.2.3732. PMID 17314515.
• Borgne-Sanchez A, Dupont S, Langonné A, Baux L, Lecoeur H, Chauvier D, Lassalle M, Déas O, Brière JJ, Brabant M, Roux P, Péchoux C, Briand JP, Hoebeke J, Deniaud A, Brenner C, Rustin P, Edelman L, Rebouillat D, Jacotot E (March 2007). "Targeted Vpr-derived peptides reach mitochondria to induce apoptosis of alphaVbeta3-expressing endothelial cells". Cell Death and Differentiation. 14 (3): 422–35. doi:10.1038/sj.cdd.4402018. PMID 16888644.
• Zhao LJ, Zhang S, Chinnadurai G (2002). "Sox9 transactivation and testicular expression of a novel human gene, KIAA0800". Journal of Cellular Biochemistry. 86 (2): 277–89. doi:10.1002/jcb.10214. PMID 12111997. S2CID 36090208.
• Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (October 1998). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.