VPRBP

Protein VPRBP is a protein that in humans is encoded by the VPRBP gene.^[5][6][7]

DCAF1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3WA0, 4CC9, 4P7I, 4PXW, 4Z8L, 5AJA
Identifiers
Aliases	DCAF1, VPRBP, Vpr (HIV-1) binding protein, DDB1 and CUL4 associated factor 1, RIP
External IDs	OMIM: 617259; MGI: 2445220; HomoloGene: 8805; GeneCards: DCAF1; OMA:DCAF1 - orthologs
EC number	2.7.11.1
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p21.2 Start 51,395,867 bp[1] End 51,500,015 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 F1 Start 106,699,073 bp[2] End 106,758,191 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm right testis left testis pericardium tendon of biceps brachii vena cava ventricular zone gastrocnemius muscle Skeletal muscle tissue of rectus abdominis ganglionic eminence Top expressed in genital tubercle tail of embryo zygote spermatid secondary oocyte spermatocyte CA3 field lactiferous gland entorhinal cortex perirhinal cortex More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity nucleotide binding kinase activity histone kinase activity (H2A-T120 specific) protein serine/threonine kinase activity protein binding ATP binding estrogen receptor binding Cellular component cytoplasm COP9 signalosome nucleus fibrillar center Cul4-RING E3 ubiquitin ligase complex Biological process regulation of transcription, DNA-templated phosphorylation negative regulation of transcription by RNA polymerase II transcription, DNA-templated cell competition in a multicellular organism protein ubiquitination V(D)J recombination B cell differentiation viral process chromatin organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9730 321006 Ensembl ENSG00000145041 ENSMUSG00000040325 UniProt Q9Y4B6 Q80TR8 RefSeq (mRNA) NM_001171904 NM_014703 NM_001349168 NM_001349169 NM_001349170 NM_001349171 NM_001387578 NM_001387579 NM_001387580 NM_001387581 NM_001387582 NM_001387583 NM_001015507 NM_001373930 NM_001373931 RefSeq (protein) NP_001165375 NP_055518 NP_001336097 NP_001336098 NP_001336099 NP_001336100 NP_001015507 NP_001360859 NP_001360860 Location (UCSC) Chr 3: 51.4 – 51.5 Mb Chr 9: 106.7 – 106.76 Mb PubMed search [3] [4]
Wikidata
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Interactions

VPRBP has been shown to interact with Merlin.^[8]