VCPIP1

Deubiquitinating protein VCIP135 is a protein that in humans is encoded by the VCPIP1 gene.^[5][6][7]

VCPIP1
Identifiers
Aliases	VCPIP1, DUBA3, VCIP135, valosin containing protein (p97)/p47 complex interacting protein 1, valosin containing protein interacting protein 1
External IDs	OMIM: 611745; MGI: 1917925; HomoloGene: 11814; GeneCards: VCPIP1; OMA:VCPIP1 - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8q13.1 Start 66,628,487 bp[1] End 66,667,231 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 A2 Start 9,788,847 bp[2] End 9,818,607 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tendon of biceps brachii endothelial cell Achilles tendon secondary oocyte testicle monocyte middle temporal gyrus internal globus pallidus Brodmann area 23 stromal cell of endometrium Top expressed in substantia nigra primary oocyte superior cervical ganglion lateral septal nucleus hand otolith organ lateral geniculate nucleus utricle cumulus cell trigeminal ganglion More reference expression data BioGPS More reference expression data
Gene ontology Molecular function thiol-dependent deubiquitinase peptidase activity cysteine-type peptidase activity hydrolase activity Cellular component cytoplasm Golgi stack Golgi apparatus endoplasmic reticulum endoplasmic reticulum lumen Biological process endoplasmic reticulum membrane fusion protein K48-linked deubiquitination Golgi organization protein ubiquitination protein K11-linked deubiquitination proteolysis Golgi reassembly mitotic cell cycle Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 80124 70675 Ensembl ENSG00000175073 ENSMUSG00000045210 UniProt Q96JH7 Q8CDG3 RefSeq (mRNA) NM_025054 NM_173443 RefSeq (protein) NP_079330 NP_775619 Location (UCSC) Chr 8: 66.63 – 66.67 Mb Chr 1: 9.79 – 9.82 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000175073 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000045210 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Nagase T, Nakayama M, Nakajima D, Kikuno R, Ohara O (Apr 2001). "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 8 (2): 85–95. doi:10.1093/dnares/8.2.85. PMID 11347906.
6. Ficarro S, Chertihin O, Westbrook VA, White F, Jayes F, Kalab P, Marto JA, Shabanowitz J, Herr JC, Hunt DF, Visconti PE (Mar 2003). "Phosphoproteome analysis of capacitated human sperm. Evidence of tyrosine phosphorylation of a kinase-anchoring protein 3 and valosin-containing protein/p97 during capacitation". The Journal of Biological Chemistry. 278 (13): 11579–89. doi:10.1074/jbc.M202325200. PMID 12509440.
7. "Entrez Gene: VCPIP1 valosin containing protein (p97)/p47 complex interacting protein 1".

Further reading

• Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Bonaldo MF, Lennon G, Soares MB (Sep 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Hartley JL, Temple GF, Brasch MA (Nov 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (Sep 2000). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Reports. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
• Uchiyama K, Jokitalo E, Kano F, Murata M, Zhang X, Canas B, Newman R, Rabouille C, Pappin D, Freemont P, Kondo H (Dec 2002). "VCIP135, a novel essential factor for p97/p47-mediated membrane fusion, is required for Golgi and ER assembly in vivo". The Journal of Cell Biology. 159 (5): 855–66. doi:10.1083/jcb.200208112. PMC 2173386. PMID 12473691.
• Wang Y, Satoh A, Warren G, Meyer HH, Wang Y (Mar 2004). "VCIP135 acts as a deubiquitinating enzyme during p97-p47-mediated reassembly of mitotic Golgi fragments". The Journal of Cell Biology. 164 (7): 973–8. doi:10.1083/jcb.200401010. PMC 2172062. PMID 15037600.
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (Aug 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (Oct 2004). "From ORFeome to biology: a functional genomics pipeline". Genome Research. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (Jan 2006). "The LIFEdb database in 2006". Nucleic Acids Research. 34 (Database issue): D415-8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.