VAP protein family

VAP proteins are conserved integral membrane proteins of the endoplasmic reticulum found in all eukaryotic cells.^[1] VAP stands for VAMP-associated protein,^[2] where VAMP stands for vesicle-associated membrane protein. Humans have two VAPs that consist of the essential Major Sperm Protein domain and linker plus transmembrane helix to attach to the ER: VAPA and VAPB.^[3] A third VAP-like protein is Motile sperm domain containing 2 (MOSPD2), which has all the elements of VAP, and like them binds FFAT motifs, but has at its N-terminus a CRAL-TRIO domain that can bind and transfer lipids.^[4]

VAMP-associated membrane protein
Identifiers
Symbol	VAP
InterPro	IPR016763
Membranome	202

VAP includes the whole family of protein homologues in all species. For example, baker's yeast expresses two VAPs: Scs2 and Scs22.^[5][6]