VAP protein family
Protein family From Wikipedia, the free encyclopedia
VAP proteins are conserved integral membrane proteins of the endoplasmic reticulum found in all eukaryotic cells.[1] VAP stands for VAMP-associated protein,[2] where VAMP stands for vesicle-associated membrane protein. Humans have two VAPs that consist of the essential Major Sperm Protein domain and linker plus transmembrane helix to attach to the ER: VAPA and VAPB.[3] A third VAP-like protein is Motile sperm domain containing 2 (MOSPD2), which has all the elements of VAP, and like them binds FFAT motifs, but has at its N-terminus a CRAL-TRIO domain that can bind and transfer lipids.[4]
| VAMP-associated membrane protein | |
|---|---|
| Identifiers | |
| Symbol | VAP |
| InterPro | IPR016763 |
| Membranome | 202 |
VAP includes the whole family of protein homologues in all species. For example, baker's yeast expresses two VAPs: Scs2 and Scs22.[5][6]
References
Wikiwand - on
Seamless Wikipedia browsing. On steroids.