Unspecific peroxygenase

Unspecific peroxygenase (EC 1.11.2.1, aromatic peroxygenase, mushroom peroxygenase, haloperoxidase-peroxygenase, Agrocybe aegerita peroxidase) is an enzyme with systematic name substrate:hydrogen peroxide oxidoreductase (RH-hydroxylating or -epoxidising).^{[1][2][3][4][5][6][7][8][9]} This enzyme catalyses the following chemical reaction

RH + H₂O₂ ${\displaystyle \rightleftharpoons }$ ROH + H₂O

Unspecific peroxygenase
Identifiers
EC no.	1.11.2.1
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

Unspecific peroxygenase is a heme-thiolate protein comparable to Cytochrome P450 in the ability to catalyze a variety of P450 reactions (hence "unspecific"), but forms a unique, solely fungal, protein family of extracellular enzymes.

References

1. Ullrich R, Nüske J, Scheibner K, Spantzel J, Hofrichter M (August 2004). "Novel haloperoxidase from the agaric basidiomycete Agrocybe aegerita oxidizes aryl alcohols and aldehydes". Applied and Environmental Microbiology. 70 (8): 4575–81. doi:10.1128/AEM.70.8.4575-4581.2004. PMC 492325. PMID 15294788.
2. Ullrich R, Hofrichter M (November 2005). "The haloperoxidase of the agaric fungus Agrocybe aegerita hydroxylates toluene and naphthalene". FEBS Letters. 579 (27): 6247–50. doi:10.1016/j.febslet.2005.10.014. PMID 16253244.
3. Anh DH, Ullrich R, Benndorf D, Svatos A, Muck A, Hofrichter M (September 2007). "The coprophilous mushroom Coprinus radians secretes a haloperoxidase that catalyzes aromatic peroxygenation". Applied and Environmental Microbiology. 73 (17): 5477–85. doi:10.1128/AEM.00026-07. PMC 2042081. PMID 17601809.
4. Ullrich R, Dolge C, Kluge M, Hofrichter M (December 2008). "Pyridine as novel substrate for regioselective oxygenation with aromatic peroxygenase from Agrocybe aegerita". FEBS Letters. 582 (29): 4100–6. doi:10.1016/j.febslet.2008.11.006. PMID 19022254. S2CID 28889201.
5. Aranda E, Kinne M, Kluge M, Ullrich R, Hofrichter M (April 2009). "Conversion of dibenzothiophene by the mushrooms Agrocybe aegerita and Coprinellus radians and their extracellular peroxygenases". Applied Microbiology and Biotechnology. 82 (6): 1057–66. doi:10.1007/s00253-008-1778-6. PMID 19039585. S2CID 28195958.
6. Kinne M, Poraj-Kobielska M, Aranda E, Ullrich R, Hammel KE, Scheibner K, Hofrichter M (June 2009). "Regioselective preparation of 5-hydroxypropranolol and 4'-hydroxydiclofenac with a fungal peroxygenase". Bioorganic & Medicinal Chemistry Letters. 19 (11): 3085–7. doi:10.1016/j.bmcl.2009.04.015. PMID 19394224.
7. Kluge M, Ullrich R, Dolge C, Scheibner K, Hofrichter M (January 2009). "Hydroxylation of naphthalene by aromatic peroxygenase from Agrocybe aegerita proceeds via oxygen transfer from H2O2 and intermediary epoxidation". Applied Microbiology and Biotechnology. 81 (6): 1071–6. doi:10.1007/s00253-008-1704-y. PMID 18815784. S2CID 28759836.
8. Kinne M, Poraj-Kobielska M, Ralph SA, Ullrich R, Hofrichter M, Hammel KE (October 2009). "Oxidative cleavage of diverse ethers by an extracellular fungal peroxygenase". The Journal of Biological Chemistry. 284 (43): 29343–9. doi:10.1074/jbc.M109.040857. PMC 2785565. PMID 19713216.
9. Pecyna MJ, Ullrich R, Bittner B, Clemens A, Scheibner K, Schubert R, Hofrichter M (October 2009). "Molecular characterization of aromatic peroxygenase from Agrocybe aegerita". Applied Microbiology and Biotechnology. 84 (5): 885–97. doi:10.1007/s00253-009-2000-1. PMID 19434406. S2CID 13141260.

External links