UQCRC1

Cytochrome b-c1 complex subunit 1, mitochondrial is a protein that in humans is encoded by the UQCRC1 gene.^[5][6]

UQCRC1
Identifiers
Aliases	UQCRC1, D3S3191, QCR1, UQCR1, ubiquinol-cytochrome c reductase core protein I, ubiquinol-cytochrome c reductase core protein 1, PKNPY
External IDs	OMIM: 191328; MGI: 107876; HomoloGene: 2525; GeneCards: UQCRC1; OMA:UQCRC1 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p21.31 Start 48,599,002 bp[1] End 48,610,976 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9 F2|9 59.63 cM Start 108,765,701 bp[2] End 108,778,691 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in apex of heart left ventricle right ventricle triceps brachii muscle myocardium of left ventricle gastrocnemius muscle muscle of thigh mucosa of transverse colon right auricle of heart vastus lateralis muscle Top expressed in proximal tubule heart right kidney muscle tissue muscle of thigh skeletal muscle tissue quadriceps femoris muscle human kidney neural layer of retina duodenum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function ubiquinol-cytochrome-c reductase activity protein-containing complex binding zinc ion binding metal ion binding catalytic activity metalloendopeptidase activity ubiquitin protein ligase binding Cellular component mitochondrial respiratory chain complex III membrane myelin sheath mitochondrion mitochondrial respirasome mitochondrial inner membrane respirasome cytosol Biological process protein processing response to activity aerobic respiration oxidative phosphorylation response to alkaloid mitochondrial electron transport, ubiquinol to cytochrome c proton transmembrane transport proteolysis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7384 22273 Ensembl ENSG00000010256 ENSMUSG00000025651 UniProt P31930 Q9CZ13 RefSeq (mRNA) NM_003365 NM_025407 RefSeq (protein) NP_003356 NP_079683 Location (UCSC) Chr 3: 48.6 – 48.61 Mb Chr 9: 108.77 – 108.78 Mb PubMed search [3] [4]
Wikidata
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Its gene product is a subunit of the respiratory chain protein Ubiquinol Cytochrome c Reductase (UQCR, Complex III or Cytochrome bc1 complex), which consists of the products of one mitochondrially encoded gene, MTCYTB (mitochondrial cytochrome b) and ten nuclear genes: UQCRC1, UQCRC2, Cytochrome c1, UQCRFS1 (Rieske protein), UQCRB, "11kDa protein", UQCRH (cyt c1 Hinge protein), Rieske Protein presequence, "cyt. c1 associated protein", and Rieske-associated protein.