UGT2B10

UDP-glucuronosyltransferase 2B10 is an enzyme that in humans is encoded by the UGT2B10 gene.^[5][6] It is responsible for glucuronidation of nicotine and cotinine.^[7][8] Due to common hypomorphic alleles of UGT2B10, glucuronidation contributes relatively little to nicotine metabolism in most people.^[9]

UGT2B10
Identifiers
Aliases	UGT2B10, UDPGT2B10, UDP glucuronosyltransferase family 2 member B10
External IDs	OMIM: 600070; MGI: 2140962; HomoloGene: 117389; GeneCards: UGT2B10; OMA:UGT2B10 - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q13.2 Start 68,815,994 bp[1] End 68,832,023 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 E1 Start 87,037,626 bp[2] End 87,054,796 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in liver right lobe of liver testicle gallbladder rectum mucosa of transverse colon islet of Langerhans kidney renal cortex left testis Top expressed in left lobe of liver pyloric antrum mucous cell of stomach left colon jejunum duodenum migratory enteric neural crest cell epithelium of stomach ileum gallbladder More reference expression data BioGPS More reference expression data
Gene ontology Molecular function glycosyltransferase activity transferase activity hexosyltransferase activity glucuronosyltransferase activity UDP-glycosyltransferase activity Cellular component integral component of membrane organelle membrane endoplasmic reticulum membrane intracellular membrane-bounded organelle endoplasmic reticulum membrane Biological process metabolism lipid metabolism Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7365 100727 Ensembl ENSG00000275190 ENSG00000109181 ENSMUSG00000029260 UniProt P36537 n/a RefSeq (mRNA) NM_001290091 NM_001075 NM_001144767 NM_153598 RefSeq (protein) NP_001066 NP_001138239 NP_001277020 n/a Location (UCSC) Chr 4: 68.82 – 68.83 Mb Chr 5: 87.04 – 87.05 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

See also

• UGT2B17