UBE2M

NEDD8-conjugating enzyme Ubc12 is a protein that in humans is encoded by the UBE2M gene.^[5][6]

UBE2M
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1TT5, 1Y8X, 2NVU, 3TDU, 3TDZ, 4GAO, 4P5O
Identifiers
Aliases	UBE2M, UBC-RS2, UBC12, hUbc12, ubiquitin conjugating enzyme E2 M
External IDs	OMIM: 603173; MGI: 108278; HomoloGene: 2952; GeneCards: UBE2M; OMA:UBE2M - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.43 Start 58,555,712 bp[1] End 58,558,954 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 A1|7 7.73 cM Start 12,769,047 bp[2] End 12,772,202 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right frontal lobe anterior cingulate cortex prefrontal cortex left testis apex of heart anterior pituitary right testis muscle of thigh Amygdala right hemisphere of cerebellum Top expressed in superior frontal gyrus muscle of thigh spermatocyte lip spermatid ventricular zone primary visual cortex dentate gyrus of hippocampal formation granule cell right kidney yolk sac More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding protein binding ATP binding ubiquitin protein ligase binding ubiquitin protein ligase activity ubiquitin-protein transferase activity NEDD8 transferase activity transferase activity Cellular component cytoplasm cytosol nucleoplasm Biological process protein neddylation positive regulation of neuron apoptotic process protein ubiquitination post-translational protein modification Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9040 22192 Ensembl ENSG00000130725 ENSMUSG00000005575 UniProt P61081 P61082 RefSeq (mRNA) NM_003969 NM_001168469 NM_001243968 NM_145578 RefSeq (protein) NP_003960 NP_003960.1 NP_001161941 NP_001230897 NP_663553 Location (UCSC) Chr 19: 58.56 – 58.56 Mb Chr 7: 12.77 – 12.77 Mb PubMed search [3] [4]
Wikidata
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The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein is linked with a ubiquitin-like protein, NEDD8, which can be conjugated to cellular proteins, such as Cdc53/culin.^[6]

Interactions

UBE2M has been shown to interact with NEDD8,^[7] PRKAR1A^[8] and UBA3.^[9]