UBE2E3

Ubiquitin-conjugating enzyme E2 E3 is a protein that in humans is encoded by the UBE2E3 gene.^[5][6]

UBE2E3
Identifiers
Aliases	UBE2E3, UBCH9, UbcM2, ubiquitin conjugating enzyme E2 E3
External IDs	OMIM: 604151; MGI: 107412; HomoloGene: 4636; GeneCards: UBE2E3; OMA:UBE2E3 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q31.3 Start 180,967,248 bp[1] End 181,076,585 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 C3 Start 78,698,468 bp[2] End 78,751,637 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence stromal cell of endometrium ventricular zone superior frontal gyrus muscle of thigh prefrontal cortex gallbladder dorsolateral prefrontal cortex Brodmann area 9 gastrocnemius muscle Top expressed in medial ganglionic eminence endocardial cushion abdominal wall Gonadal ridge fetal liver hematopoietic progenitor cell human fetus atrioventricular valve atrium ureter habenula More reference expression data BioGPS More reference expression data
Gene ontology Molecular function ATP binding nucleotide binding ubiquitin conjugating enzyme activity ubiquitin-protein transferase activity transferase activity protein binding Cellular component nucleus cytoplasm nucleoplasm cytosol Biological process protein K63-linked ubiquitination protein K48-linked ubiquitination protein K11-linked ubiquitination regulation of growth protein ubiquitination Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10477 22193 Ensembl ENSG00000170035 ENSMUSG00000027011 UniProt Q969T4 P52483 RefSeq (mRNA) NM_001278554 NM_001278555 NM_006357 NM_182678 NM_009454 NM_001356395 RefSeq (protein) NP_001265483 NP_001265484 NP_006348 NP_872619 NP_033480 NP_001343324 Location (UCSC) Chr 2: 180.97 – 181.08 Mb Chr 2: 78.7 – 78.75 Mb PubMed search [3] [4]
Wikidata
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The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein shares 100% sequence identity with the mouse and rat counterparts, which indicates that this enzyme is highly conserved in eukaryotes. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.^[6]