UBE2E2

Ubiquitin-conjugating enzyme E2 E2 is a protein that in humans is encoded by the UBE2E2 gene.^[5][6]

UBE2E2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1Y6L
Identifiers
Aliases	UBE2E2, UBCH8, ubiquitin conjugating enzyme E2 E2
External IDs	OMIM: 602163; MGI: 2384997; HomoloGene: 77337; GeneCards: UBE2E2; OMA:UBE2E2 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p24.3 Start 23,203,020 bp[1] End 23,591,794 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14|14 A1 Start 3,575,429 bp[2] End 3,896,121 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve prefrontal cortex popliteal artery tibial arteries Brodmann area 9 germinal epithelium myocardium of left ventricle cingulate gyrus anterior cingulate cortex right coronary artery Top expressed in dentate gyrus of hippocampal formation granule cell motor neuron Region I of hippocampus proper hippocampus proper fossa visual cortex barrel cortex primary visual cortex condyle trigeminal ganglion More reference expression data BioGPS More reference expression data
Orthologs Species Human Mouse Entrez 7325 218793 Ensembl ENSG00000182247 ENSMUSG00000058317 UniProt Q96LR5 Q91W82 RefSeq (mRNA) NM_152653 NM_001370225 NM_001370226 NM_001370227 NM_001370228 NM_144839 NM_001360327 NM_001360328 RefSeq (protein) NP_689866 NP_001357154 NP_001357155 NP_001357156 NP_001357157 NP_659088 NP_001347256 NP_001347257 Location (UCSC) Chr 3: 23.2 – 23.59 Mb Chr 14: 3.58 – 3.9 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000182247 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000058317 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Kimura M, Hattori T, Matsuda Y, Yoshioka T, Sumi N, Umeda Y, Nakashima S, Okano Y (Dec 1997). "cDNA cloning, characterization, and chromosome mapping of UBE2E2 encoding a human ubiquitin-conjugating E2 enzyme". Cytogenet Cell Genet. 78 (2): 107–11. doi:10.1159/000134639. PMID 9371400.
6. "Entrez Gene: UBE2E2 ubiquitin-conjugating enzyme E2E 2 (UBC4/5 homolog, yeast)".

Further reading

• Auffray C, Behar G, Bois F, et al. (1995). "[IMAGE: molecular integration of the analysis of the human genome and its expression]". Comptes Rendus de l'Académie des Sciences, Série III. 318 (2): 263–72. PMID 7757816.
• Moynihan TP, Ardley HC, Nuber U, et al. (1999). "The ubiquitin-conjugating enzymes UbcH7 and UbcH8 interact with RING finger/IBR motif-containing domains of HHARI and H7-AP1". J. Biol. Chem. 274 (43): 30963–8. doi:10.1074/jbc.274.43.30963. PMID 10521492.
• Niwa J, Ishigaki S, Doyu M, et al. (2001). "A novel centrosomal ring-finger protein, dorfin, mediates ubiquitin ligase activity". Biochem. Biophys. Res. Commun. 281 (3): 706–13. doi:10.1006/bbrc.2001.4414. PMID 11237715.
• Pringa E, Martinez-Noel G, Muller U, Harbers K (2001). "Interaction of the ring finger-related U-box motif of a nuclear dot protein with ubiquitin-conjugating enzymes". J. Biol. Chem. 276 (22): 19617–23. doi:10.1074/jbc.M100192200. PMID 11274149.
• Ito K, Adachi S, Iwakami R, et al. (2001). "N-Terminally extended human ubiquitin-conjugating enzymes (E2s) mediate the ubiquitination of RING-finger proteins, ARA54 and RNF8". Eur. J. Biochem. 268 (9): 2725–32. doi:10.1046/j.1432-1327.2001.02169.x. PMID 11322894.
• Wheeler TC, Chin LS, Li Y, et al. (2002). "Regulation of synaptophysin degradation by mammalian homologues of seven in absentia". J. Biol. Chem. 277 (12): 10273–82. doi:10.1074/jbc.M107857200. PMID 11786535.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Kim KI, Giannakopoulos NV, Virgin HW, Zhang DE (2004). "Interferon-Inducible Ubiquitin E2, Ubc8, Is a Conjugating Enzyme for Protein ISGylation". Mol. Cell. Biol. 24 (21): 9592–600. doi:10.1128/MCB.24.21.9592-9600.2004. PMC 522249. PMID 15485925.
• Plafker SM, Plafker KS, Weissman AM, Macara IG (2005). "Ubiquitin charging of human class III ubiquitin-conjugating enzymes triggers their nuclear import". J. Cell Biol. 167 (4): 649–59. doi:10.1083/jcb.200406001. PMC 2172591. PMID 15545318.
• Takeuchi T, Iwahara S, Saeki Y, et al. (2005). "Link between the Ubiquitin Conjugation System and the ISG15 Conjugation System: ISG15 Conjugation to the UbcH6 Ubiquitin E2 Enzyme". J. Biochem. 138 (6): 711–9. doi:10.1093/jb/mvi172. PMID 16428300.

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human Ubiquitin-conjugating enzyme E2 E2