UBASH3A

Ubiquitin-associated and SH3 domain-containing protein A is a protein that in humans is encoded by the UBASH3A gene.^[5][6]

UBASH3A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2CRN
Identifiers
Aliases	UBASH3A, CLIP4, STS-2, TULA, TULA-1, ubiquitin associated and SH3 domain containing A
External IDs	OMIM: 605736; MGI: 1926074; HomoloGene: 56833; GeneCards: UBASH3A; OMA:UBASH3A - orthologs
Gene location (Human) Chr. Chromosome 21 (human)[1] Band 21q22.3 Start 42,403,447 bp[1] End 42,447,684 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 A3.3- B1 Start 31,426,847 bp[2] End 31,465,866 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte blood lymph node testicle thymus spleen appendix gallbladder rectum tonsil Top expressed in thymus mesenteric lymph nodes granulocyte blood embryo yolk sac parasympathetic nervous system thyroid gland pharynx tongue More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding phosphatase activity Cellular component cytoplasm cytosol extracellular exosome nucleus nucleoplasm Golgi apparatus Biological process regulation of cytokine production negative regulation of T cell receptor signaling pathway negative regulation of signal transduction dephosphorylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 53347 328795 Ensembl ENSG00000160185 ENSMUSG00000042345 UniProt P57075 Q3V3E1 RefSeq (mRNA) NM_001001895 NM_001243467 NM_018961 NM_177823 RefSeq (protein) NP_001001895 NP_001230396 NP_061834 NP_808491 Location (UCSC) Chr 21: 42.4 – 42.45 Mb Chr 17: 31.43 – 31.47 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000160185 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000042345 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Wattenhofer M, Shibuya K, Kudoh J, Lyle R, Michaud J, Rossier C, Kawasaki K, Asakawa S, Minoshima S, Berry A, Bonne-Tamir B, Shimizu N, Antonarakis SE, Scott HS (Apr 2001). "Isolation and characterization of the UBASH3A gene on 21q22.3 encoding a potential nuclear protein with a novel combination of domains". Hum Genet. 108 (2): 140–7. doi:10.1007/s004390000453. PMID 11281453. S2CID 22719211.
6. "Entrez Gene: UBASH3A ubiquitin associated and SH3 domain containing, A".

Further reading

• Smirnova EV, Collingwood TS, Bisbal C, et al. (2008). "TULA proteins bind to ABCE-1, a host factor of HIV-1 assembly, and inhibit HIV-1 biogenesis in a UBA-dependent fashion". Virology. 372 (1): 10–23. doi:10.1016/j.virol.2007.10.012. PMID 18006034.
• Collingwood TS, Smirnova EV, Bogush M, et al. (2007). "T-cell ubiquitin ligand affects cell death through a functional interaction with apoptosis-inducing factor, a key factor of caspase-independent apoptosis". J. Biol. Chem. 282 (42): 30920–8. doi:10.1074/jbc.M706870200. PMID 17709377.
• Bertelsen V, Breen K, Sandvig K, et al. (2007). "The Cbl-interacting protein TULA inhibits dynamin-dependent endocytosis". Exp. Cell Res. 313 (8): 1696–709. doi:10.1016/j.yexcr.2007.02.017. hdl:10852/28097. PMID 17382318.
• Hu YH, Warnatz HJ, Vanhecke D, et al. (2006). "Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins". BMC Genomics. 7: 155. doi:10.1186/1471-2164-7-155. PMC 1526728. PMID 16780588.
• Hoeller D, Crosetto N, Blagoev B, et al. (2006). "Regulation of ubiquitin-binding proteins by monoubiquitination". Nat. Cell Biol. 8 (2): 163–9. doi:10.1038/ncb1354. PMID 16429130. S2CID 1324257.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Kowanetz K, Crosetto N, Haglund K, et al. (2004). "Suppressors of T-cell receptor signaling Sts-1 and Sts-2 bind to Cbl and inhibit endocytosis of receptor tyrosine kinases". J. Biol. Chem. 279 (31): 32786–95. doi:10.1074/jbc.M403759200. PMID 15159412.
• Feshchenko EA, Smirnova EV, Swaminathan G, et al. (2004). "TULA: an SH3- and UBA-containing protein that binds to c-Cbl and ubiquitin". Oncogene. 23 (27): 4690–706. doi:10.1038/sj.onc.1207627. PMID 15107835. S2CID 34698870.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.