Type II collagen

Type II collagen is the basis for hyaline cartilage, including the articular cartilages at joint surfaces. It is formed by homotrimers of collagen, type II, alpha 1 chains.

collagen, type II, alpha 1 (primary osteoarthritis, spondyloepiphyseal dysplasia, congenital)
Identifiers
Symbol	COL2A1
Alt. symbols	SEDC
NCBI gene	1280
HGNC	2200
OMIM	120140
RefSeq	NM_001844
UniProt	P02458
Other data
Locus	Chr. 12 q13.11-q13.2
Search for Structures Swiss-model Domains InterPro

It makes up 50% of all protein in cartilage and 85–90% of collagen of articular cartilage.

Type II collagen is organised into fibrils. This fibrillar network of collagen allows the cartilage to entrap the proteoglycan aggregate, as well as providing tensile strength to the tissue. Oral administration of native type II collagen induces oral tolerance to pathological immune responses ^[1] and the administration of type II collagen tablets together with paracetamol might be more effective at reducing symptoms of osteoarthritis than paracetamol by itself.^[2][3]

See also

• Type I collagen
• Collagen, type III, alpha 1