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Chemical compound From Wikipedia, the free encyclopedia
Tofogliflozin (INN,[1]: 88 USAN, codenamed CSG452) is an experimental drug for the treatment of diabetes mellitus and is being developed by Chugai Pharma in collaboration with Kowa and Sanofi.[2] It is an inhibitor of subtype 2 sodium-glucose transport protein (SGLT2), which is responsible for at least 90% of the glucose reabsorption in the kidney. As of September 2012[update], the drug is in Phase III clinical trials.[3][4][needs update]
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Other names | CSG452 |
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Formula | C22H28O7 |
Molar mass | 404.459 g·mol−1 |
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The active moiety or anhydrous form (ChemSpider ID: 28530778, CHEMBL2110731) has the chemical formula C22H26O6 and a molecular mass of 386.44 g/mol.
The United States Adopted Name tofogliflozin applies to the monohydrate, which is the form used as a drug.[5] The International Nonproprietary Name tofogliflozin applies to the anhydrous compound[1] and the drug form is referred to as tofogliflozin hydrate.
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