Thioxanthene

Thioxanthene is a chemical compound in which the oxygen atom in xanthene is replaced with a sulfur atom. It is also related to phenothiazine. Several of its derivatives are used as typical antipsychotics in the treatment of schizophrenia and other psychoses.

Thioxanthene

Names
Preferred IUPAC name 9H-Thioxanthene[1]
Other names 10H-Dibenzo[b,e]thiin
Identifiers
CAS Number	261-31-4 Y
3D model (JSmol)	Interactive image
ChEBI	CHEBI:51055 Y
ChEMBL	ChEMBL79451 Y
ChemSpider	60819 Y
ECHA InfoCard	100.005.430
PubChem CID	67495
UNII	1J3P67894A Y
CompTox Dashboard (EPA)	DTXSID20180732
InChI InChI=1S/C13H10S/c1-3-7-12-10(5-1)9-11-6-2-4-8-13(11)14-12/h1-8H,9H2 Y Key: PQJUJGAVDBINPI-UHFFFAOYSA-N Y InChI=1/C13H10S/c1-3-7-12-10(5-1)9-11-6-2-4-8-13(11)14-12/h1-8H,9H2 Key: PQJUJGAVDBINPI-UHFFFAOYAP
SMILES S2c1ccccc1Cc3c2cccc3
Properties
Chemical formula	C13H10S
Molar mass	198.28 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). N verify (what is YN ?) Infobox references

Derivatives

The derivatives of thioxanthene used clinically as antipsychotics include:

• Chlorprothixene (Cloxan, Taractan, Truxal)
• Clopenthixol (Sordinol)
• Flupenthixol (Depixol, Fluanxol)
• Thiothixene (Navane)
• Zuclopenthixol (Cisordinol, Clopixol, Acuphase)

The therapeutic efficacy of these drugs is related to their ability to antagonize the D₂ receptors in the brain, though they have actions at other sites such as serotonin, adrenaline, and histamine receptors as well which mostly contribute to side effects.

The thioxanthenes, as a class, are closely related chemically to the phenothiazines. The major structural difference is that the nitrogen at position 10 in the phenothiazines is replaced by a carbon atom with a double bond to the side chain.^[2] This difference is noted in the illustration of flupenthixol, which shows a double-bonded carbon in the number 10 position (opposite the sulfur molecule in the central chain).

References

1. International Union of Pure and Applied Chemistry (2014). Nomenclature of Organic Chemistry: IUPAC Recommendations and Preferred Names 2013. The Royal Society of Chemistry. p. 213. doi:10.1039/9781849733069. ISBN 978-0-85404-182-4.
2. Goodman & Gilman's The Pharmacological Basis of Therapeutics

External links

• Thioxanthenes at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• MedlinePlus