Terbogrel

Terbogrel
Names
	IUPAC name (5E)-6-{3-[tert-Butyl(cyano)carbamimidamido]phenyl}-6-pyridin-3-ylhex-5-enoic acid
	Other names (5E)-6-[m-(3-tert-Butyl-2-cyanoguanidino)phenyl]-6-(3-pyridyl)-5-hexenoic acid
Identifiers
CAS Number	149979-74-8 ;
3D model (JSmol)	Interactive image;
ChEMBL	ChEMBL281398 ;
ChemSpider	4952549 ;
KEGG	D06077 ;
PubChem CID	6449876;
UNII	5Z4KWQ5OGN ;
	InChI InChI=1S/C23H27N5O2/c1-23(2,3)28-22(26-16-24)27-19-10-6-8-17(14-19)20(11-4-5-12-21(29)30)18-9-7-13-25-15-18/h6-11,13-15H,4-5,12H2,1-3H3,(H,29,30)(H2,26,27,28)/b20-11+ Key: XUTLOCQNGLJNSA-RGVLZGJSSA-N ; InChI=1S/C23H27N5O2/c1-23(2,3)28-22(26-16-24)27-19-10-6-8-17(14-19)20(11-4-5-12-21(29)30)18-9-7-13-25-15-18/h6-11,13-15H,4-5,12H2,1-3H3,(H,29,30)(H2,26,27,28)/b20-11+;
	SMILES N#CN\C(=N/C(C)(C)C)Nc2cccc(C(=C/CCCC(=O)O)\c1cccnc1)c2;
Properties
Chemical formula	C23H27N5O2
Molar mass	405.502 g·mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). verify (what is ?) Infobox references

Terbogrel (INN^[1]) is an experimental drug that has been studied for its potential to prevent the vasoconstricting and platelet-aggregating action of thromboxanes. Terbogrel is an orally available thromboxane A₂ receptor antagonist and a thromboxane A synthase inhibitor.^[2]^[3] The drug was developed by Boehringer Ingelheim.

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A phase 2 clinical trial of terbogrel was discontinued due to its induction of leg pain.^[4]

See also