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Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia
TTC37 (Tetratricopeptide repeat domain 37) is a protein which in humans is encoded by gene TTC37, located on chromosome 5. [5][6]
TTC37 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Aliases | TTC37, KIAA0372, Ski3, THES, tetratricopeptide repeat domain 37 | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 614589; MGI: 2679923; HomoloGene: 40966; GeneCards: TTC37; OMA:TTC37 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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The length of the polypeptide chain is 1,564 amino acids, and the molecular weight is 175,486 Da.[6] TTC37 contains six tetratricopeptide repeat domains.[6]
TTC37 is a component of the Ski complex which is involved in exosome mediated RNA decay.[7]
It is localized in the cytoplasmatic space and the cell nucleus.[5]
Mutation in the TTC37 gene are associated with tricho-hepato-enteric syndrome.[8][9]
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