TTC1

Tetratricopeptide repeat protein 1 is a protein that in humans is encoded by the TTC1 gene.^[5][6]

TTC1
Identifiers
Aliases	TTC1, TPR1, tetratricopeptide repeat domain 1
External IDs	OMIM: 601963; MGI: 1914077; HomoloGene: 2485; GeneCards: TTC1; OMA:TTC1 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q33.3 Start 160,009,113 bp[1] End 160,065,543 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 B1.1 Start 43,620,339 bp[2] End 43,638,835 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in apex of heart Achilles tendon cingulate gyrus left ventricle anterior cingulate cortex right frontal lobe C1 segment Brodmann area 9 prefrontal cortex islet of Langerhans Top expressed in blastocyst genital tubercle tail of embryo morula spermatocyte spermatid secondary oocyte muscle of thigh zygote yolk sac More reference expression data BioGPS More reference expression data
Gene ontology Molecular function unfolded protein binding protein binding Cellular component peroxisomal membrane cytosol Biological process protein folding Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7265 66827 Ensembl ENSG00000113312 ENSMUSG00000041278 UniProt Q99614 Q91Z38 RefSeq (mRNA) NM_003314 NM_001282500 NM_133795 RefSeq (protein) NP_001269429 NP_003305 NP_598556 Location (UCSC) Chr 5: 160.01 – 160.07 Mb Chr 11: 43.62 – 43.64 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

TTC1 has been shown to interact with HSPA4.^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000113312 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000041278 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Murthy AE, Bernards A, Church D, Wasmuth J, Gusella JF (Nov 1996). "Identification and characterization of two novel tetratricopeptide repeat-containing genes". DNA Cell Biol. 15 (9): 727–35. doi:10.1089/dna.1996.15.727. PMID 8836031.
6. "Entrez Gene: TTC1 tetratricopeptide repeat domain 1".
7. Oh WK, Song Jaewhan (Aug 2003). "Cooperative interaction of Hsp40 and TPR1 with Hsp70 reverses Hsp70-HspBp1 complex formation". Mol. Cells. 16 (1). Korea (South): 84–91. doi:10.1016/S1016-8478(23)13770-8. ISSN 1016-8478. PMID 14503850.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Marty C, Browning DD, Ye RD (2003). "Identification of tetratricopeptide repeat 1 as an adaptor protein that interacts with heterotrimeric G proteins and the small GTPase Ras". Mol. Cell. Biol. 23 (11): 3847–58. doi:10.1128/MCB.23.11.3847-3858.2003. PMC 155206. PMID 12748287.
• Oh WK, Song J (2004). "Cooperative interaction of Hsp40 and TPR1 with Hsp70 reverses Hsp70-HspBp1 complex formation". Mol. Cells. 16 (1): 84–91. doi:10.1016/S1016-8478(23)13770-8. PMID 14503850.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID 15761153. S2CID 39457788.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.