TST (gene)

Thiosulfate sulfurtransferase is an enzyme that in humans is encoded by the TST gene.^[5][6]

TST
Identifiers
Aliases	TST, RDS, thiosulfate sulfurtransferase
External IDs	OMIM: 180370; MGI: 98852; HomoloGene: 37759; GeneCards: TST; OMA:TST - orthologs
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q12.3 Start 37,010,859 bp[1] End 37,020,183 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15 E1|15 37.47 cM Start 78,283,756 bp[2] End 78,290,107 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of transverse colon right lobe of liver mucosa of sigmoid colon mucosa of ileum right adrenal cortex jejunal mucosa duodenum left adrenal gland left adrenal cortex kidney tubule Top expressed in olfactory epithelium left lobe of liver pyloric antrum gastric mucosa mucous cell of stomach epithelium of stomach esophagus adrenal gland left colon optic nerve More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity 5S rRNA binding thiosulfate sulfurtransferase activity RNA binding Cellular component mitochondrial inner membrane extracellular exosome mitochondrion mitochondrial matrix extracellular space Biological process rRNA transport rRNA import into mitochondrion epithelial cell differentiation cyanate catabolic process sulfur amino acid catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7263 22117 Ensembl ENSG00000128311 ENSMUSG00000044986 UniProt Q16762 P52196 RefSeq (mRNA) NM_003312 NM_001270483 NM_009437 RefSeq (protein) NP_001257412 NP_003303 NP_033463 Location (UCSC) Chr 22: 37.01 – 37.02 Mb Chr 15: 78.28 – 78.29 Mb PubMed search [3] [4]
Wikidata
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The product of this gene is a mitochondrial matrix enzyme that is encoded by the nucleus. It may play roles in cyanide detoxification, the formation of iron-sulfur proteins, and the modification of sulfur-containing enzymes.

The gene product contains two highly conservative domains (rhodanese homology domains), suggesting these domains have a common evolutionary origin.^[6]