TSPAN2

Tetraspanin-2 is a protein that in humans is encoded by the TSPAN2 gene.^[5][6][7]

TSPAN2
Identifiers
Aliases	TSPAN2, NET3, TSN2, TSPAN-2, tetraspanin 2
External IDs	OMIM: 613133; MGI: 1917997; HomoloGene: 21169; GeneCards: TSPAN2; OMA:TSPAN2 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p13.2 Start 115,048,011 bp[1] End 115,089,503 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 F2.2 Start 102,641,845 bp[2] End 102,708,829 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of uterus muscle layer of sigmoid colon popliteal artery tibial arteries right coronary artery tail of epididymis Descending thoracic aorta ascending aorta islet of Langerhans gastric mucosa Top expressed in ventral tegmental area lateral geniculate nucleus globus pallidus deep cerebellar nuclei left lung lobe lateral hypothalamus right lung medial geniculate nucleus right lung lobe central gray substance of midbrain More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component integral component of membrane myelin sheath plasma membrane integral component of plasma membrane membrane Biological process astrocyte development myelination cell surface receptor signaling pathway axon development brain development oligodendrocyte differentiation inflammatory response microglia development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10100 70747 Ensembl ENSG00000134198 ENSMUSG00000027858 UniProt O60636 Q922J6 RefSeq (mRNA) NM_001308315 NM_001308316 NM_005725 NM_001243132 NM_027533 RefSeq (protein) NP_001295244 NP_001295245 NP_005716 NP_001230061 NP_081809 Location (UCSC) Chr 1: 115.05 – 115.09 Mb Chr 3: 102.64 – 102.71 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility.^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000134198 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000027858 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Todd SC, Doctor VS, Levy S (Sep 1998). "Sequences and expression of six new members of the tetraspanin/TM4SF family". Biochim Biophys Acta. 1399 (1): 101–4. doi:10.1016/s0167-4781(98)00087-6. PMID 9714763.
6. Berditchevski F (Dec 2001). "Complexes of tetraspanins with integrins: more than meets the eye". J Cell Sci. 114 (Pt 23): 4143–51. doi:10.1242/jcs.114.23.4143. PMID 11739647.
7. "Entrez Gene: TSPAN2 tetraspanin 2".

Further reading

• Hemler ME (2002). "Specific tetraspanin functions". J. Cell Biol. 155 (7): 1103–7. doi:10.1083/jcb.200108061. PMC 2199333. PMID 11756464.
• Gregory SG; Barlow KF; McLay KE; et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
• Gerhard DS; Wagner L; Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T; Suzuki Y; Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL; Feingold EA; Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

External links

• TSPAN2 human gene location in the UCSC Genome Browser.
• TSPAN2 human gene details in the UCSC Genome Browser.